[1]卢 昉,何东盈,劳美玲,等.治甲一方治疗甲状腺功能亢进肝气郁结证临床研究[J].陕西中医,2021,(5):601-603,607.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.014]
　LU Fang,HE Dongying,LAO Meiling,et al.Hyperthyroidism with liver-Qi stagnation syndrome treated by the Zhijia Yifang[J].,2021,(5):601-603,607.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.014]
点击复制

治甲一方治疗甲状腺功能亢进肝气郁结证临床研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年5期
页码:
601-603,607
栏目:
临床研究
出版日期:
2021-05-05

文章信息/Info

Title:
Hyperthyroidism with liver-Qi stagnation syndrome treated by the Zhijia Yifang
作者:
卢 昉; 何东盈; 劳美玲; 郎江明
( 广州中医药大学附属佛山市中医院内分泌科,广东 佛山 528000)
Author(s):
LU Fang; HE Dongying; LAO Meiling; LANG Jiangming
(Department of Endocrinology,Foshan Hospital of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Foshan 528000,China)
关键词:
甲状腺功能亢进;  治甲一方;  中医证候积分;  甲状腺激素水平;  空腹血糖
Keywords:
Hyperthyroidism;  Zhijia Yifang;  TCM syndrome score;  Thyroid hormone levels;  Fasting plasma glucose
分类号:
R 581.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.05.014
文献标志码:
A
摘要:
目的:观察治甲一方治疗甲状腺功能亢进的有效性和安全性。方法:将180例甲状腺功能亢进患者随机分为对照组110例和观察组70例,对照组患者给予甲巯咪唑口服,观察组患者给予治甲一方口服,连续治疗6个月。比较两组治疗的临床效果、中医证候积分,测定甲状腺激素水平、糖脂代谢相关指标、血清中相关因子含量,记录不良反应。结果:观察组、对照组的有效率分别为92.86%、81.82%,以观察组疗效更好(P<0.05); 治疗后,与对照组进行组间比较,观察组患者的胸胁胀满、情志不畅、口苦口干等主要症状的中医证候积分显著降低(均P<0.05); 观察组患者治疗后的TSH水平显著升高,FT4、FT3、TRAb水平显著降低(均P<0.05); 观察组的糖脂代谢紊乱纠正程度更明显,2hPBG、FBG显著降低,TC、TG显著升高(均P<0.05); 与观察组5.71%的不良反应发生率相比,对照组的不良反应发生率26.05%相对较高(P<0.05)。结论:治甲一方在减轻甲状腺功能亢进患者临床症状、改善甲状腺功能方面有良效,更利于调节脂质代谢,减轻炎症程度。
Abstract:
Objective:To observe the efficacy and safety of treating hyperthyroidism with the Zhijia Yifang.Methods:180 patients with hyperthyroidism were randomly divided into the control group(n=110)and the observation group(n=70).Patients in the control group were given methimazole for oral administration,while those in the observation group were given Zhijia Yifang for 6 consecutive months.The clinical effect of treatment and TCM syndrome score were compared between the two groups.The thyroid hormone levels,related indicators of glucose and lipid metabolism,and the content of related factors in serum were measured,and the adverse reactions were recorded.Results:The effective rate of the observation group and the control group was 92.86% and 81.82% respectively.The effect of the observation group was better(P<0.05).After treatment,compared with the control group,the scores of TCM syndromes of patients in the observation group were significantly lower(all P<0.05).In the observation group,TSH levels were significantly increased after treatment,while FT4,FT3 and TRAb levels were significantly decreased(all P<0.05).In the observation group,the degree of glucose and lipid metabolism disorder correction was more obvious,2hPBG and FBG were significantly reduced,and TC and TG were significantly increased(all P<0.05).Compared with 5.71% of the observation group,26.05% of the control group had a relatively high incidence of adverse reactions(P<0.05).Conclusion:Zhijia Yifang is effective in relieving the clinical symptoms and improving the thyroid function of patients with hyperthyroidism,it is more beneficial to regulate lipid metabolism and reduce inflammation.

参考文献/References:

[1] Franziska L,Heike W,Elena T,et al.Disruption of BMP signaling prevents hyperthyroidism-induced bone loss in male mice[J].Journal of Bone and Mineral Research,2020,35(10):2058-2069.
[2] Xie CY,He CZ,Gao J,et al.Efficacy and safety of tripterygium glycosides in the treatment of hyperthyroidism:A systemic review and meta-analysis[J].Medicine,2020,99(38):282-295.
[3] 沈振芳,钱 靖,焦雪花,等.甲巯咪唑片治疗甲状腺功能亢进患者的临床研究[J].中国临床药理学杂志,2020,36(18):2769-2771.
[4] 李玉梅,张定华,连 琯,等.甲状腺功能亢进的中医药研究进展[J].中医研究,2020,33(5):75-78.
[5] 施丽娟,刘 娟,张晓冉,等.丹栀逍遥散联合甲巯咪唑治疗甲状腺功能亢进症临床研究[J].陕西中医,2020,41(9):1276-1278.
[6] 中华医学会内分泌学分会.甲状腺疾病诊治指南-甲状腺功能减退症[J].中华内科杂志,2007,46(11):967-971.
[7] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:226-229.
[8] Evron JM,Esfandiari NH,Papaleontiou M.Cancer incidence and mortality following treatment of hyperthyroidism with radioactive iodine[J].Current Opinion in Endocrinology & Diabetes and Obesity,2020,27(5):323-328.
[9] 陈淑娴,张立颖,褚俏梅,等.TPOAb和TgAb阳性甲状腺功能亢进症患者131Ⅰ治疗前后血清IL-17和IGF-1水平变化研究[J].陕西医学杂志,2020,49(6):675-678.
[10] Han XY,Xiao H,Chen J,et al.The substance basis of poria ameliorates hypothyroidism other than hyperthyroidism based on proteomics and metabolomics[J].The FASEB Journal,2020,34(9):11970-11982.
[11] 雷 雯,张家林,季艳丹,等.柴胡疏肝散联合甲巯咪唑治疗肝郁气滞型甲状腺功能亢进症的临床效果[J].中国医院用药评价与分析,2020,20(8):917-919.
[12] 雷 佳,邓秀敏,刘世巍,等.小柴胡汤合旋覆花汤联合小剂量甲巯咪唑治疗甲状腺功能亢进临床研究[J].陕西中医,2018,39(12):1775-1777.
[13] 刘少杰,施燕红,王桂芬,等.中医从肝论治甲状腺功能亢进的临床疗效[J].辽宁中医杂志,2020,47(10):93-96.
[14] 鲍凤和.从疏肝柔肝法论治甲状腺功能亢进[J].陕西中医药大学学报,2020,43(5):47-48.
[15] 王瑛瑛,刘怀珍.刘怀珍治疗甲状腺功能亢进症经验[J].中医药临床杂志,2019,31(12):2229-2232.
[16] 董伟伟,吴彩兰.甲状腺功能亢进症与血栓形成相关性研究进展[J].陕西医学杂志,2021,50(2):251-253.
[17] 周荷玲,王 珺,许春燕.甲状腺功能正常的妊娠糖尿病患者甲状腺激素水平与糖脂代谢的相关性[J].中国卫生检验杂志,2020,30(13):1613-1615.
[18] 陈 红,李 阳,何旭梅,等.甲状腺功能亢进症患者血皮质醇、促肾上腺皮质激素含量水平与疾病程度相关性研究[J].陕西医学杂志,2020,49(9):1168-1171.
[19] 高丽娟,贾维宁.丙硫氧嘧啶、甲硫咪唑对妊娠期甲状腺功能亢进患者妊娠结局及糖脂代谢的影响比较[J].国际检验医学杂志,2019,40(2):188-191.
[20] 曹晋峰.131Ⅰ加丙硫氧嘧啶对甲状腺功能亢进患者的甲状腺激素、糖脂代谢的影响[J].湖南师范大学学报:医学版,2018,15(5):148-151.

相似文献/References:

[1]何逸俊,魏 华.甲状腺功能亢进患者的中医症型分布特点及与甲功、血脂相关性分析[J].陕西中医,2024,(9):1190.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.008]
　HE Yijun,WEI Hua.The distribution characteristics of TCM syndromes in hyperthyroidism and the correlation analysis with thyroid function and blood lipid[J].,2024,(5):1190.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.008]

备注/Memo

备注/Memo:
基金项目:广东省中医药局科研课题(20151101)
更新日期/Last Update: 2021-05-10