[1]张秀琳,惠 振,王苏雷,等.加减地黄饮子治疗帕金森病疼痛临床研究[J].陕西中医,2021,(5):620-624.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.019]
　ZHANG Xiulin,HUI Zhen,WANG Sulei,et al.Clinical study of Modified Dihuang Yinzi on pain of Parkinson's disease[J].,2021,(5):620-624.[doi:DOI:10.3969/j.issn.1000-7369.2020.05.019]
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加减地黄饮子治疗帕金森病疼痛临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年5期
页码:
620-624
栏目:
临床研究
出版日期:
2021-05-05

文章信息/Info

Title:
Clinical study of Modified Dihuang Yinzi on pain of Parkinson's disease
作者:
张秀琳1; 惠 振2; 王苏雷2; 肖 婧3; 陈 清4; 梁 艳2; 唐莉莉2; 徐成成2; 陈 畅2; 赵 杨2; 张臻年2
(1.南京中医药大学,江苏 南京 210023; 2.南京中医药大学附属南京中医院,江苏 南京 210022; 3.江苏省第二中医院,江苏 南京 211005; 4.南京市浦口区中医院,江苏 南京 210032)
Author(s):
ZHANG Xiulin; HUI Zhen; WANG Sulei; XIAO Jing; CHEN Qing; LIANG Yan; TANG Lili; XU Chengcheng; CHEN Chang; ZHAO Yang; ZHANG Zhennian
(Nanjing University of Chinese Medicine,Nanjing 210023,China )
关键词:
帕金森病疼痛;  加减地黄饮子;  中医证候积分;  疼痛视觉模拟量表;  5-羟色胺
Keywords:
Parkinson's disease pain;  Modified Dihuang Yinzi;  TCM syndrome score;  VAS score;  5-HT
分类号:
R 742.5
DOI:
DOI:10.3969/j.issn.1000-7369.2020.05.019
文献标志码:
A
摘要:
目的:本研究旨在探讨加减地黄饮子对帕金森病疼痛的临床研究。方法:以68例帕金森病疼痛患者为研究对象,按随机数字表法分为对照组34例,给予抗帕金森西药治疗,治疗组34例,在对照组治疗的基础上给予加减地黄饮子治疗。对比治疗前后两组中医证候积分、疼痛视觉模拟量表(VAS)评分、国王帕金森病疼痛评价量表(KPPS)评分及血清单胺类神经递质5-羟色胺(5-HT),去甲肾上腺素(NE)及神经肽Y(NPY)的变化情况,观察两组临床疗效。结果:治疗后,两组头摇肢颤、行动缓慢、腰膝酸软、善忘或神呆严重、手足出汗、头晕耳鸣、语言障碍、失眠多梦、盗汗颧红、口咽干燥、急躁时颤振加重评分均较治疗前降低,与对照组比较,治疗组头摇肢颤、行动缓慢、腰膝酸软、善忘或神呆严重、手足出汗、头晕耳鸣、语言障碍、失眠多梦、盗汗颧红、口咽干燥、急躁时颤振加重评分均更低,差异有统计学意义(P<0.05)。治疗后,治疗组临床疗效高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均较治疗前降低,与对照组比较,治疗组VAS评分更低,差异有统计学意义(P<0.05)。两组口面部疼痛、慢性疼痛、神经根性疼痛、胀痛、骨骼肌疼痛、症状波动相关疼痛、夜间疼痛评分均较治疗前降低,与对照组比较,治疗组口面部疼痛、慢性疼痛、神经根性疼痛、胀痛、骨骼肌疼痛、症状波动相关疼痛、夜间疼痛评分均更低,差异有统计学意义(P<0.05)。两组血清5-HT、NE、NPY均较治疗前上升,与对照组比较,治疗组血清5-HT、NE、NPY均更高(P<0.05)。结论:加减地黄饮子对帕金森病疼痛患者效果显著,既能降低疼痛评分,也可改善患者临床症状。
Abstract:
Objective:This study aims to explore the clinical study of the modified Dihuang Yinzi on Parkinson's disease pain.Methods:A total of 68 patients with Parkinson's disease were selected as the research objects.They were divided into a control group(34 cases with anti-Parkinson drugs)and treatment according to a random number table.Treatment group(34 cases),on the basis of the treatment of the control group,given the modified Dihuang Yinzi treatment.The scores of TCM syndromes,visual analogue scale for pain(VAS)scores,King Parkinson's disease pain assessment scale(KPPS)scores and the serum monoamine neurotransmitter serotonin(5-HT)were compared before and after treatment.The changes of norepinephrine(NE)and neuropeptide Y(NPY)were observed in the clinical efficacy of the two groups.Results:After treatment,the two groups had head shaking,slow movement,sore waist and knees,forgetfulness or severe mental dazedness,sweating of hands and feet,dizziness,tinnitus,language disorder,and insomnia.Dreams,night sweats,zygomatic redness,dry oropharyngeal,and irritable flutter aggravated scores were all lower than before treatment.Compared with the control group,the treatment group had head shaking and limb tremor,slow movement,weak waist and knees,forgetfulness or severe daze,and extremities.Sweat,dizziness,tinnitus,language disorder,insomnia and dreaminess,night sweats,zygomatic redness,oropharyngeal dryness,and aggravated flutter during irritability were all lower,with significant differences(P<0.05).After treatment,the clinical efficacy of the treatment group was higher than that of the control group(94.12% vs 73.53%),the difference was significant(P<0.05).After treatment,the VAS scores of the two groups were lower than before treatment.Compared with the control group,the VAS scores of the treatment group were lower and the difference was significant(P<0.05).The two groups of oral and facial pain,chronic pain,radicular pain,distending pain,skeletal muscle pain,symptom fluctuation-related pain,and night pain scores were all lower than before treatment.Compared with the control group,the treatment group had oral and facial pain,chronic pain,radicular pain,distending pain,Skeletal muscle pain,symptom fluctuation-related pain,and night pain scores were all lower,with significant differences(P<0.05).The serum 5-HT,NE,and NPY of the two groups increased compared with before treatment.Compared with the control group,the treatment group serum 5-HT,NE,and NPY were all higher,and the difference was significant(P<0.05).Conclusion:Modified Dihuang Yinzi has a significant effect on patients with Parkinson's disease pain,which can reduce pain scores and improve clinical symptoms,and is worthy of clinical application.

参考文献/References:

[1] Hayes MT.Parkinson's disease and parkinsonism[J].Am J Med,2019,132(7):802-807.
[2] 董丽果,祖 洁,张 伟,等.帕金森病相关性疼痛的相关因素及其对生活质量的影响[J].临床神经病学杂志,2019,32(4):254-257.
[3] Reich SG,Savitt JM.Parkinson's disease[J].Med Clin North Am,2019,103(2):337-350.
[4] 许玉珉,马云枝,沈晓明,等.中医药治疗帕金森病睡眠障碍研究进展[J].中华中医药杂志,2018,33(11):261-263.
[5] 张琳婧,梁羽茜,胡秀华,等.中医药对帕金森病的临床疗效及相关信号通路的研究进展[J].中医药学报,2019,47(3):124-129.
[6] 中华医学会神经病学分会帕金森病及运动障碍学组.中国帕金森病的诊断标准(2016版)[J].中华神经科杂志,2016,49(4):2004-2007.
[7] Raja SN,Carr DB,Cohen M,等.国际疼痛研究协会疼痛定义修订版:概念,挑战和折中[J].中华疼痛学杂志,2020,16(5):341-348.
[8] 中华全国中医学会老年医学会.中医老年颤证诊断和疗效评定标准[J].北京中医药大学学报,1992,15(4):39-41.
[9] 高 靓,蔡来生,李小兵,等.通过国王帕金森病疼痛量表分析帕金森病患者疼痛的临床特点[J].临床神经病学杂志,2020,33(2):112-116.
[10] 宁 静,杨 晖,李 灿,等.11C-CFT PET/CT显像与帕金森病综合评定量表评分相关性分析[J].中华保健医学杂志,2020,22(1):49-52.
[11] 杨 蕊,朱雪泉,肖 乐,等.视觉模拟评定量表与抑郁症状快速评估量表的一致性研究[J].中国医刊,2018,53(8):918-921.
[12] Ng JS.Palliative care for Parkinson's disease[J].Ann Palliat Med,2018,7(3):296-303.
[13] 李 耀,祖 洁,董丽果,等.帕金森病伴疼痛的临床特点及相关因素[J].中国神经免疫学和神经病学杂志,2019,26(4):265-268,280.
[14] 于振华.地黄饮子加减联合针灸治疗帕金森患者的临床观察[J].中国医药指南,2019,17(25):7-8.
[15] 王妮娜.地黄饮子合芍药甘草汤治疗帕金森病疗效观察[J].山西中医,2018,34(2):15-16.
[16] 王源江,赵振强,许 叶,等.恩他卡朋片联合左旋多巴片对帕金森病患者的临床研究[J].中国临床药理学杂志,2019,35(2):112-114.
[17] 徐树平,王 岩,刘凤国,等.帕金森病合并抑郁患者血清TNF-α,5-HT,E,IL-1β变化与抑郁程度相关性分析[J].医学临床研究,2019,36(12):2307-2309.
[18] 李晨曦,张一帆,白如玉,等.卡巴拉汀联合司来吉兰治疗帕金森病的临床研究[J].现代药物与临床,2019,34(8):2356-2360.
[19] 程文波,杨栓锁,杨 芹,等.美多巴对老年血管性帕金森病合并阵发性心房颤动的影响[J].中华老年医学杂志,2018,37(6):646-649.
[20] 杨荣梅,胡希文,王艳涛,等.高频重复经颅磁刺激联合度洛西汀在重度抑郁发作急性期的疗效[J].临床精神医学杂志,2019,29(2):118-120.

备注/Memo

备注/Memo:
基金项目:南京市卫生科技发展专项资金资助项目(YKK18134); 南京市“十三五”名中医(刘孔江)工作室建设项目(LKJ-2017-NJ); 南京中医药大学“江苏高校护理学优势学科建设工程资助项目”(2019YSHL098); 江苏中医药局“中医脑病学”重点学科培育项目(NBPY201704); 南京市“十三五”名中医(王敬卿)工作室建设项目(WJQ-2019-NJ)
更新日期/Last Update: 2021-05-10