[1]谢 佳,胡 晓,夏宛廷,等.四逆散合寿胎丸加减治疗生育期崩漏脾肾亏虚证疗效及对患者凝血功能的影响[J].陕西中医,2021,(7):849-852.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.008]
　XIE Jia,HU Xiao,XIA Wanting,et al.Effect of Sini powder combined with modified Shoutai pill on metrorrhagia of spleen-kidney deficiency during child-bearing and its influences on coagulation function[J].,2021,(7):849-852.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.008]
点击复制

四逆散合寿胎丸加减治疗生育期崩漏脾肾亏虚证疗效及对患者凝血功能的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年7期
页码:
849-852
栏目:
临床研究
出版日期:
2021-07-09

文章信息/Info

Title:
Effect of Sini powder combined with modified Shoutai pill on metrorrhagia of spleen-kidney deficiency during child-bearing and its influences on coagulation function
作者:
谢 佳1; 胡 晓2; 夏宛廷1; 江若兰3; 邓琳雯1
(1.成都中医药大学附属医院妇科,四川 成都 610072; 2.成都市温江区中医医院医务科,四川 成都 611130; 3.成都中医药大学临床医学院,四川 成都 610072)
Author(s):
XIE Jia; HU Xiao; XIA Wanting; Jiang Ruolan; DENG Linwen
(Department of Gynecology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China)
关键词:
崩漏;  四逆散;  寿胎丸;  生育期;  凝血功能;  脾肾亏虚证
Keywords:
Metrorrhagia;  Sini powder;  Shoutai pill;  Child-bearing period;  Coagulation function;  Spleen kidney deficiency syndrome
分类号:
R 271.2
DOI:
DOI:10.3969/j.issn.1000-7369.2020.07.008
文献标志码:
A
摘要:
目的:探讨四逆散合寿胎丸加减治疗生育期崩漏脾肾亏虚证的疗效及对患者凝血功能的影响。方法:以76例生育期崩漏患者作为研究对象,辨证为脾肾亏虚证,随机数字表分为两组,对照组38例使用地屈孕酮片治疗; 观察组38例在对照组基础上使用四逆散合寿胎丸加减治疗,均连续治疗3个月经周期后,观察两组疗效、中医症状积分、血常规指标、出血天数、子宫内膜厚度及以及不良反应发生情况。结果:观察组2例患者在治疗过程中未按时按量服药,退出本研究; 对照组38例均完成研究。停药3个周期后,观察组、对照组治疗有效率91.67%、81.58%比较,差异无统计学意义(P>0.05)。治疗3个周期后,观察组患者月经量、月经持续天数、面色和次症面浮肢肿、四肢不温、便溏的症状积分均显著低于对照组(P<0.05)。治疗3个周期后,观察组血红蛋白(Hb)水平显著高于对照组,部分活化凝血活酶时间(APTT)和凝血酶原时间(PT)均显著低于对照组(P<0.05)。治疗3个周期后,观察组出血天数和子宫内膜厚度均显著低于对照组(P<0.05)。观察组不良反应发生率2.78%和对照组0.00%比较,差异无统计学意义(P>0.05)。结论:四逆散合寿胎丸加减可显著改善生育期崩漏患者中医症状和凝血功能,提升Hb水平,减少出血持续天数,安全性较高。
Abstract:
Objective:To explore the curative effect of Sini powder combined with modified Shoutai pill on metrorrhagia of spleen-kidney deficiency during child-bearing and its influences on coagulation function.Methods:A total of 76 patients with metrorrhagia of spleen-kidney deficiency during child-bearing were enrolled as the research objects.They were divided into control group(38 cases,dydrogesterone tablets)and observation group(38 cases,Sini powder combined with modified Shoutai pill on basis of control group)by random number table method.After three menstrual cycles of consecutive treatment,the curative effect,scores of TCM symptom,blood routine indexes,duration of bleeding,endometrial thickness and occurrence of adverse reactions in both groups were observed.Results:During treatment,there were 2 cases in observation group not regularly taking medication,and dropping out from the study halfway.A total of 36 cases completed the study,while all cases in control group completed the study.After 3 cycles of drug withdrawal,there was no significant difference in the response rate of treatment between observation group and control group [91.67%(33/36)vs 81.58%(31/38)](P>0.05).After 3 cycles of treatment,menstrual volume,menstrual duration,scores of complexion and secondary superficial hematoma,cold limbs,and loose stools in observation group were significantly lower than those in control group(P<0.05).After 3 cycles of treatment,serum activated partial thromboplastin time(APTT)and prothrombin time(PT)in observation group were significantly lower than those in control group,while hemoglobin(Hb)level was significantly higher than that in control group(P<0.05).After 3 cycles of treatment,duration of bleeding and endometrial thickness in observation group were significantly lower than those in control group(P<0.05).At the end of treatment,there was no significant difference in the incidence of adverse reactions between observation group and control group [2.78%(1/36)vs 0.00%(0/38)](P>0.05).Conclusion: Sini powder combined with modified Shoutai pill can significantly improve TCM symptoms and coagulation function of patients with metrorrhagia during child-bearing,increase Hb level,and shorten bleeding duration,with high safety.

参考文献/References:

[1] 陈 绵,陈燕娥,吴 颖.固崩止漏汤联合妈富隆治疗围绝经期异常子宫出血临床研究[J].陕西中医,2020,41(4):453-455.
[2] 唐 林,李克敏,罗国林.非孕期腹腔镜与孕期经阴道宫颈环扎术对治疗宫颈机能不全的疗效比较[J].西部医学,2018,30(5):53-56,60.
[3] Huss A,Schaap K,Kromhout H.A survey on abnormal uterine bleeding among radiographers with frequent MRI exposure using intrauterine contraceptive devices[J].Magn Reson Med,2018,79(2):1083-1089.
[4] Brown SM,Fifield SW,Pizzi MA,et al.A preliminary observational study of anovulatory uterine bleeding after aneurysmal subarachnoid hemorrhage[J].J Neurosci Nurs,2017,49(6):363-371.
[5] 谢 幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:334-335.
[6] 马宝璋.中医妇科学[M].北京:中国医药科技出版社,2016:95-101.
[7] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:62-63.
[8] Vervoort A,Vissers J,Hehenkamp W,et al.The effect of laparoscopic resection of large niches in the uterine caesarean scar on symptoms,ultrasound findings and quality of life:A prospective cohort study[J].BJOG,2018,125(3):317-325.
[9] 谈晓双,文乐兮.《医宗金鉴?妇科心法要诀?崩漏门》组方用药特点分析[J].湖南中医药大学学报,2020,40(2):170-174.
[10] Cramer SF,Heller DS.A review and reconsideration of nonneoplastic myometrial pathology[J].Int J Surg Pathol,2018,26(2):104-119.
[11] Steward R,Carney P,Law A,et al.Long-term outcomes after elective sterilization procedures:A comparative retrospective cohort study of medicaid patients[J].Contraception,2018,97(5):428-433.
[12] 马媛媛,张 娜,索素兰.李光荣运用补肾调周法治疗崩漏经验[J].中医杂志,2020,61(19):1692-1695.
[13] Grzechocinska B,Dabrowski FA,Chlebus M,et al.Expression of matrix metalloproteinase enzymes in endometrium of women with abnormal uterine bleeding[J].Neuro Endocrinol Lett,2018,38(8):537-543.
[14] 刘 帅,龚志忠,蔡 云,等.1076例崩漏患者中医证型分布与影响因素分析[J].中国临床医生杂志,2020,48(7):872-875.
[15] 郭东艳,范 宇,程江雪,等.生地黄汤不同配伍比例干预“肾虚血瘀”型崩漏的实验研究[J].中南药学,2020,18(2):182-188.
[16] 郑 璇,高昕妍,鲁 刚,等.从“四逆散”与“升降散”浅谈气之升降出入[J].辽宁中医药大学学报,2020,22(7):126-128.
[17] 陈陶秀,匡继林.寿胎丸加味联合西药治疗妊娠早期绒毛膜下血肿临床研究[J].河南中医,2020,40(3):434-437.
[18] 姜立娟,张文风.丁甘仁从冲任辨治崩漏[J].长春中医药大学学报,2020,36(3):454-457.
[19] 王 妍,蔡梦瑶,魏绍斌.川派妇科名中医王祚久先生治疗崩漏的经验[J].成都中医药大学学报,2020,43(1):46-47,61.
[20] 潘琳琳,王 淞,孙海洋,等.国医大师张志远治疗崩漏的临证经验[J].中华中医药杂志,2020,35(6):2889-2892.

相似文献/References:

[1]王学梅,谢 萍.逐瘀止崩法治疗崩漏出血期研究进展*[J].陕西中医,2019,(3):407.
　WANG Xuemei,XIE Ping..Research and Progress of treatment of eliminating blood stasis and stopping metrorrhagia for metrorrhagia and metrostaxis[J].,2019,(7):407.
[2]龙丹丹,姜 爽.清胆解毒汤合四逆散治疗急性胰腺炎肝胆湿热证临床研究[J].陕西中医,2024,(6):767.[doi:DOI:10.3969/j.issn.1000-7369.2024.06.009]
　LONG Dandan,JIANG Shuang.Qingdan Jiedu decoction combined with Sini powder in the treatment of acute pancreatitis with liver and gallbladder damp-heat syndrome[J].,2024,(7):767.[doi:DOI:10.3969/j.issn.1000-7369.2024.06.009]
[3]赵佩然,赵玉强,李安琪,等.四逆散对代谢相关脂肪性肝病微循环障碍的影响及机制研究[J].陕西中医,2024,(10):1299.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.001]
　ZHAO Peiran,ZHAO Yuqiang,LI Anqi,et al.Study on the effect and mechanism of Sini powder on the microcirculation disturbance of metabolic associated fatty liver disease[J].,2024,(7):1299.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.001]

备注/Memo

备注/Memo:
基金项目:四川省科技厅苗子工程项目(2018105); 四川省中医院科技发展基金资助项目(18ZX02); 川派中医妇科的文化渊源与发展研究项目(2020WH036); 成都中医药大学“杏林学者”学科人才科研提升计划立项项目(ZRQN2020016)
更新日期/Last Update: 2021-07-07