[1]钟义兰,刘尚丽,史雅锋.归经当归拈痛汤联合西药治疗风湿性关节炎疗效及对患者类风湿因子的影响[J].陕西中医,2021,(7):918-921.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.028]
　ZHONG Yilan,LIU Shangli,SHI Yafeng.Guijing Danggui Niantong decoction combined with western medicine in the treatment of rheumatoid arthritis and its influence on rheumatoid factors[J].,2021,(7):918-921.[doi:DOI:10.3969/j.issn.1000-7369.2020.07.028]
点击复制

归经当归拈痛汤联合西药治疗风湿性关节炎疗效及对患者类风湿因子的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年7期
页码:
918-921
栏目:
临床研究
出版日期:
2021-07-09

文章信息/Info

Title:
Guijing Danggui Niantong decoction combined with western medicine in the treatment of rheumatoid arthritis and its influence on rheumatoid factors
作者:
钟义兰1; 刘尚丽1; 史雅锋2
(1.四川省骨科医院,四川 成都 610041; 2.西安市第五医院,陕西 西安710082)
Author(s):
ZHONG Yilan; LIU Shangli; SHI Yafeng
(Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)
关键词:
风湿性关节炎;  归经当归拈痛汤;  症状评分;  类风湿因子;  骨代谢水平
Keywords:
Rheumatoid arthritis;  Guijing Danggui Niantong decoction;  Symptom score;  Rheumatoid factor;  Bone metabolism level
分类号:
R 593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2020.07.028
文献标志码:
A
摘要:
目的:探讨归经当归拈痛汤联合西药在风湿热痹证风湿性关节炎中的临床效果及对患者类风湿因子的影响。方法:将风湿热痹证风湿性关节炎患者84例随机分为两组各42例。对照组采用常规西药治疗,观察组联合归经当归拈痛汤治疗,均连续治疗8周。比较两组临床疗效、症状评分、类风湿因子、骨代谢水平。结果:观察组临床总有效率高于对照组(P<0.05); 观察组治疗后关节疼痛、关节肿胀、关节压痛、关节灼热、晨僵评分低于对照组(P<0.05),且RF、ESR及GR均低于对照组(P<0.05),25(OH)D、N-MID、T-PINP水平均高于对照组(P<0.05),β-CTX水平低于对照组(P<0.05)。结论:归经当归拈痛汤联合西药用于风湿热痹证风湿性关节炎中能降低症状评分,可获得较高的近期疗效,同时能降低类风湿因子水平,改善骨代谢水平。
Abstract:
Objective:To investigate the clinical effects of Guijing Danggui Niantong decoction combined with western medicine in rheumatoid arthritis and its influence on rheumatoid factors.Methods:84 cases of rheumatoid arthritis patients with rheumatoid arthritis syndrome were divided into two groups with 42 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Guijing Danggui Niantong decoction for 8 consecutive weeks.The clinical efficacy,symptom score,rheumatoid factor,bone metabolism level.Results:The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).The scores of joint pain,joint swelling,joint tenderness,joint burning,and morning stiffness after treatment in the observation group were lower than those in the control group(P<0.05).ESR and GR were lower than the control group(P<0.05),25(OH)D,N-MID,and T-PINP levels were higher than the control group(P<0.05),and β-CTX levels were lower than the control group(P<0.05).The incidence of adverse reactions during the treatment of the two groups was not statistically significant(P>0.05),but the recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion: Guijing Danggui Niantong decoction combined with western medicine for rheumatoid arthritis with rheumatism-heat arthritis can reduce the symptom score and obtain a higher short-term curative effect.At the same time,it can reduce the level of rheumatoid factors,improve the level of bone metabolism,and enhance the joints of patients function,does not increase the incidence of adverse reactions.

参考文献/References:

[1] 高 远,李永吉.类风湿性关节炎发病机制及中药靶向治疗的研究进展[J].中国药房,2016,27(35):5030-5034.
[2] 王海清,叶云凤,饶珈铭,等.广州15岁及以上人群风湿性关节炎流行病学调查[J].中华疾病控制杂志,2015,19(10):999-1002.
[3] 陈 琳,周 静,姚血明,等.中药外敷联合西药治疗类风湿关节炎临床疗效和安全性的Meta分析[J].中西医结合护理,2020,6(9):19-25.
[4] 全 健,丁文涛,武 辉.穴位注射配合桂枝芍药知母汤加减治疗类风湿性关节炎临床研究[J].陕西中医,2019,40(5):671-673.
[5] 袁 林,吴金玉,唐 婕,等.白虎加桂枝汤联合西药治疗类风湿关节炎风湿热痹证临床观察[J].辽宁中医药大学学报,2019,21(12):168-171.
[6] 占志颖.归经当归拈痛汤联合西药治疗痛风性关节炎缓解期的临床观察[D].武汉:湖北中医药大学,2019.
[7] 黄国付,陈 可.实用类风湿关节炎康复指南[M].北京:人民军医出版社,2012:46-51.
[8] 赵 娟,张卓莉.2019年美国风湿病学会/欧洲抗风湿病联盟免疫球蛋白G4相关性疾病的分类标准问世[J].中华风湿病学杂志,2020,24(3):215-216.
[9] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:115-119.
[10] 吕厚山.关节炎外科学[M].北京:人民军医出版社,2002:226-228.
[11] 刘兆宜,沈洲立,岳跃兵,等.类风湿关节炎并发动脉粥样硬化相关性研究进展[J].陕西医学杂志,2020,49(11):1534-1537.
[12] 王 涛,李志军.类风湿关节炎的诊断与治疗[J].中华全科医学,2020,18(2):170-171.
[13] 许相洋,张文州.类风湿关节炎的诊断及其药物治疗研究进展[J].中国医药导报,2016,13(30):56-59.
[14] 窦生瑞.滋水涵木除痹汤联合甲氨蝶呤治疗更年期类风湿关节炎者的临床疗效观察[D].西宁:青海大学,2020.
[15] 贺地震,刘谦性.沙利度胺联合甲氨蝶呤治疗类风湿性关节炎疗效及对患者调节性T细胞、白细胞介素-6水平影响临床研究[J].陕西医学杂志,2019,48(1):111-113.
[16] 占志颖.归经当归拈痛汤联合西药治疗痛风性关节炎缓解期的临床观察[D].武汉:湖北中医药大学,2019.
[17] 龚 雪,汪 元.类风湿关节炎患者血管内皮生长因子的变化及其相关性分析[J].风湿病与关节炎,2021,10(1):12-14,36.
[18] 戴凤翔,邱联群.当归拈痛汤联合西乐葆治疗急性痛风性关节炎的临床疗效观察[J].广州中医药大学学报,2020,37(3):422-425.
[19] 梁桂平.绝经后骨关节炎与骨代谢的相关性及中医证型分布研究[D].广州:广州中医药大学,2019.
[20] 杨庆万,安 阳,项飞燕,等.引火汤对类风湿关节炎患者骨代谢的影响[J].陕西中医,2020,41(1):75-77.

备注/Memo

备注/Memo:
基金项目:四川省干部保健科研项目(川干研2020-604)
更新日期/Last Update: 2021-07-07