[1]赵 娟,李朝友,吴银弟,等.茵栀黄颗粒联合蓝光治疗黄疸疗效及对新生儿肝功能、胆红素、脑功能的影响[J].陕西中医,2021,(8):1092-1095.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.026]
　ZHAO Juan,LI Chaoyou,WU Yindi,et al.Effect of Yinzhihuang granule and blue light therapy on liver function,bilirubin level and brain function of neonatal jaundice[J].,2021,(8):1092-1095.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.026]
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茵栀黄颗粒联合蓝光治疗黄疸疗效及对新生儿肝功能、胆红素、脑功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年8期
页码:
1092-1095
栏目:
临床研究
出版日期:
2021-08-05

文章信息/Info

Title:
Effect of Yinzhihuang granule and blue light therapy on liver function,bilirubin level and brain function of neonatal jaundice
作者:
赵 娟1; 李朝友1; 吴银弟1; 梅家伟2
(1.合肥市第一人民医院儿科,安徽 合肥 230000; 2.安徽中医药大学第一附属医院儿科,安徽 合肥 230000)
Author(s):
ZHAO Juan; LI Chaoyou; WU Yindi; MEI Jiawei
(Department of Pediatrics,the First People's Hospital of Hefei,Hefei 230000,China)
关键词:
新生儿黄疸;  茵栀黄颗粒;  蓝光治疗;  肝功能;  胆红素;  脑功能;  炎症
Keywords:
Neonatal jaundice;  Yinzhihuang granules;  Blue light therapy;  Liver function;  Bilirubin;  Brain function;  Inflammation
分类号:
R 722.17
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.026
文献标志码:
A
摘要:
目的:研究茵栀黄颗粒口服联合蓝光治疗对新生儿黄疸肝功能、胆红素水平及脑功能的影响。方法:选择120例新生儿黄疸患儿并随机分为观察组和对照组各60例。对照组患儿采用蓝光治疗; 观察组患者在对照组基础上联合茵栀黄颗粒治疗,两组均治疗7 d。比较两组患儿治疗前后肝功能、胆红素水平、炎症反应水平及治疗后脑功能损伤情况和疗效。结果:治疗后观察组谷草转氨酶(AST)和谷丙转氨酶(ALT)水平显著低于对照组(P<0.05); 总胆红素(TBIL)、间接胆红素(IBIL)水平显著低于对照组(P<0.05); 白介素-6(IL-6)、C反应蛋白(CRP)水平显著低于对照组(P<0.05); 脑功能正常率显著高于对照组(P<0.05); 总有效率明显高于对照组(P<0.05)。结论:新生儿黄疸患儿通过茵栀黄颗粒口服联合蓝光治疗对改善肝功能、调节胆红素水平和炎症反应、改善脑功能有积极意义,整体疗效较理想。
Abstract:
Objective:To study the effect of Yinzhihuang combined with blue light therapy on liver function,bilirubin level and brain function of neonatal jaundice.Methods:120 cases with neonatal jaundice were selected as the research objects,and they were randomly divided into the observation group and the control group,with 60 cases in each group.The children in the control group were treated with blue light therapy.The patients in the observation group were treated with Yinzhihuang granules on the basis of the control group,and both groups were treated for 7 days.The liver function,bilirubin level,inflammatory reaction level,brain function injury and curative effect of the two groups of children before and after treatment were compared.Results:After treatment,the levels of glutamic oxaloacetic transaminase(AST)and glutamic pyruvic transaminase(ALT)in the observation group were significantly lower than those in the control group(P<0.05).The levels of total bilirubin(TBIL)and indirect bilirubin(IBIL)were significantly lower than those in the control group(P<0.05).The levels of interleukin-6(IL-6)and C-reactive protein(CRP)were significantly lower than those in the control group(P<0.05).The normal rate of brain function was significantly higher than that of the control group(P<0.05).The total effective rate was higher than that of the control group(P<0.05).Conclusion:Oral administration of Yinzhihuang granules combined with blue light therapy has positive significance in improving liver function,regulating bilirubin level and inflammatory reaction,and improving brain function of cases with neonatal jaundice,with ideal overall curative effect.

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备注/Memo

备注/Memo:
基金项目:安徽省自然科学基金资助项目(1808085MH364)
更新日期/Last Update: 2021-08-09