[1]曹 亮,田皎丁,杨 娜,等.针刺联合大黄虫汤加味治疗糖尿病周围神经病变临床研究[J].陕西中医,2021,(8):1120-1123.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.033]
　CAO Liang,TIAN Jiaoding,YANG Na,et al.Effect of acupuncture combined with modified Dahuang Zhechong decoction in patients with type 2 DPN[J].,2021,(8):1120-1123.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.033]
点击复制

针刺联合大黄虫汤加味治疗糖尿病周围神经病变临床研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年8期
页码:
1120-1123
栏目:
针灸经络
出版日期:
2021-08-05

文章信息/Info

Title:
Effect of acupuncture combined with modified Dahuang Zhechong decoction in patients with type 2 DPN
作者:
曹 亮; 田皎丁; 杨 娜; 王京晶; 孟晶晶
(秦皇岛市中医医院,河北 秦皇岛 066000)
Author(s):
CAO Liang; TIAN Jiaoding; YANG Na; WANG Jingjing; MENG Jingjing
(Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066000,China)
关键词:
2型糖尿病周围神经病变;  针刺;  大黄虫汤;  脂蛋白相关磷脂酶A2;  视黄醇结合蛋白4
Keywords:
Type 2 diabetic peripheral neuropathy;  Acupuncture;  Dahuang Zhechong decoction;  Lipoprotein associated phospholipase A2;  Retinol binding protein 4
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.033
文献标志码:
A
摘要:
目的:研究针刺联合大黄虫汤加味对2型糖尿病周围神经病变(DPN)患者脂蛋白相关磷脂酶A2(Lp-PLA2)、视黄醇结合蛋白4(RBP4)的影响。方法:选取154例2型DPN患者,治疗手段不同分为对照组和研究组,各78例。检测两组患者治疗前、治疗2周后、4周后Lp-PLA2、RBP4水平及运动神经、感觉神经传导速度,评定患者中医证候评分、神经症状积分及治疗效果。结果:与治疗前相比,两组患者治疗两周后、4周后Lp-PLA2、RBP4水平、中医证候积分、神经症状积分均降低,运动神经传导速度、感觉神经传导速度均升高; 与对照组治疗两周后、4周后相比,研究组治疗两周后、4周后Lp-PLA2、RBP4水平、中医证候积分、神经症状积分均降低,运动神经传导速度、感觉神经传导速度均升高(P<0.05); 研究组治疗4周后总有效率高于对照组(P<0.05)。结论:针刺联合大黄虫汤加味可降低2型DPN患者Lp-PLA2、RBP4水平,减轻患者炎性反应。
Abstract:
Objective:To study the effects of acupuncture combined with rhubarb stinging decoction on lipoprotein-associated phospholipase A2(LP-PLA2)and retinol-binding protein 4(RBP4)in patients with type 2 diabetic peripheral neuropathy(DPN),respectively.Methods:154 patients with type 2 DPN.Treatment is divided into control group and study group,78 cases each.Detection of motor and sensory nerve conduction velocity before,after 2 weeks and 4 weeks Lp-PLA2,RBP4 treatment,to evaluate the score of TCM syndromes,the score of neurological symptoms and the therapeutic effect.Results:The Lp-PLA2,RBP4 level,TCM syndrome score and NS score were lower after 2 weeks and 4 weeks,and the motor nerve conduction velocity and sensory nerve conduction velocity were higher than those of control group after 2 weeks and 4 weeks.The Lp-PLA2,RBP4 level,TCM syndrome score and neurological symptom score were lower after 2 weeks(P<0.05),and the total effective rate of study group after 4 weeks was higher than that of control group after 4 weeks(P<0.05).Conclusion:Acupuncture combined with rhubarb stinging decoction can reduce the Lp-PLA2,RBP4 level and inflammatory response of type 2 DPN patients.

参考文献/References:

[1] Su JB,Zhao LH,Zhang XL,et al.HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients[J].Cardiovasc Diabetol,2018,17(1):47.
[2] 杨 冰,马国斌.降糖祛瘀汤联合α-硫辛酸治疗气阴两虚兼血瘀型2型糖尿病并发周围神经病变临床研究[J].陕西中医,2021,42(4):493-495.
[3] 石 敏,邹 健,李乔岳,等.2型糖尿病患者糖化白蛋白和糖化血红蛋白比值与周围神经病变相关性研究[J].陕西医学杂志,2020,49(12):1557-1560.
[4] 祁玉杰,鲍 超,李建兵,等.吴旭教授从“经筋”论针刺治疗儿童抽动障碍[J].中国针灸,2021,41(2):193-195.
[5] 谢 帆,吴思雨,许陵冬.大黄虫丸对慢性肾脏病肾脏保护作用的研究进展[J].世界科学技术-中医药现代化,2020,22(6):1803-1806.
[6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[7] 庞国明,闫 镛,朱 璞,等.糖尿病周围神经病变中医诊疗规范初稿[J].中华中医药杂志,2010,25(2):260-264.
[8] 谢恬恬,简小兵.归龙汤对阳虚血瘀型糖尿病周围神经病变患者TNF-α、IL-6水平的影响[J].陕西中医,2017,38(12):1703-1705.
[9] Zhang B,Zhao W,Tu J,et al.The relationship between serum 25-hydroxyvitamin D concentration and type 2 diabetic peripheral neuropathy:A systematic review and a meta-analysis[J].Medicine(Baltimore),2019,98(48):18118.
[10] 杜菲菲,王 妮,齐 茗,等.生脉注射液联合α-硫辛酸治疗糖尿病患者伴周围神经病变的临床疗效[J].海军医学杂志,2019,40(4):363-365.
[11] Hosny SS,Nasr MS,Ibrahim RH,et al.Relation between plasma apelin level and peripheral neuropathy in type 2 diabetic patients[J].Diabetes Metab Syndrl,2019,13(1):626-629.
[12] 郭 强,赵 欢,闫 旭,等.中医外治法联合依帕司他治疗糖尿病周围神经病变患者临床疗效及安全性Meta分析[J].世界中西医结合杂志,2021,16(1):17-22.
[13] 冯帅东.中医内治法治疗糖尿病周围神经病变临床研究进展[J].疑难病杂志,2020,19(1):96-99.
[14] 张 明,许丽雯.丹红注射液治疗糖尿病及其并发症用药分析[J].上海医药,2018,39(23):56-59.
[15] 赵秋波,徐凤梅,李杰玉.双侧足三里穴位注射胰激肽原酶治疗糖尿病周围血管病变疗效观察[J].上海针灸杂志,2018,37(9):992-996.
[16] 李雪青,王金艳,孙 薇,等.针刺肾俞五十七穴防治糖尿病胰岛素抵抗的临床研究[J].中医药学报,2018,46(1):90-93.
[17] 韩 伟,魏芳晶.冠心病患者胰岛素抵抗指数与重组β细胞营养因子、脂蛋白相关磷脂酶A2的相关性分析[J].临床误诊误治,2018,31(7):82-86.
[18] 张渭芳,苏 岑,赵康仁,等.血清Lp-PLA2含量对早期无症状糖尿病周围神经病变的筛查价值[J].江苏大学学报:医学版,2017,27(4):324-326.
[19] 张渭芳,苏 岑,赵康仁,等.早期糖尿病周围神经病患者的EMG改变及其与血清脂蛋白相关磷脂酶A2水平的关系[J].临床神经病学杂志,2017,30(5):358-361.
[20] 李淑兵.黄芪桂枝五物汤加减联合针刺治疗糖尿病周围神经病变(气虚血瘀证)的临床研究[J].黑龙江医药,2016,29(6):1124-1125.
[21] 李 飞,杨远龙.大黄虫汤加减联合甲钴胺治疗糖尿病周围神经病变的临床效果评价[J].糖尿病天地,2018,15(10):28-29.

相似文献/References:

[1]赵卫锋,陆 鹤△,任媛媛,等.周志杰主任医师从经筋论治膝骨关节病及运用膝四针临证经验*[J].陕西中医,2020,(2):230.
　ZHAO Weifeng,LU He,REN Yuanyuan,et al.Academic thoughts of chief physician ZHOU Zhijie in treating knee osteoarthriosis based on muscle region theory and the corsesponing clinical experience of knee four needls[J].,2020,(8):230.
[2]鄢国清,易 成△,薛 红,等.针灸治疗肿瘤研究进展*[J].陕西中医,2020,(4):547.
[3]蔡和平,侯 丽,董 青△,等.中医综合外治法治疗晚期恶性肿瘤合并胃痞理论及应用探讨*[J].陕西中医,2020,(6):783.[doi:DOI:10.3969/j.issn.10007369.2020.06.023]
[4]田利军,郭宇松,刘 星,等.葛根汤联合针刺治疗青少年颈椎生理曲度异常所致颈源性头痛疗效及对患者脑血管功能状况的影响*[J].陕西中医,2020,(7):875.[doi:DOI:10.3969/j.issn.10007369.2020.07.010]
[5]高建清,雷艳容,陈红蓓.中药外敷痛点及腧穴配合针刺对晚期肺癌患者癌痛程度、睡眠质量的影响*[J].陕西中医,2020,(7):972.[doi:DOI:10.3969/j.issn.10007369.2020.07.041]
　GAO Jianqing,LEI Yanrong,CHEN Hongbei..Effect of external application of Chinese medicine at pain points and acupoints combined with acupuncture on reducing cancer pain level and sleep quality of patients with advanced lung cancer[J].,2020,(8):972.[doi:DOI:10.3969/j.issn.10007369.2020.07.041]
[6]陈立梁,曾 骥.针刺联合运动想象疗法治疗脑卒中后认知功能障碍临床研究*[J].陕西中医,2020,(7):983.[doi:DOI:10.3969/j.issn.10007369.2020.07.044]
　CHEN Liliang,ZENG Ji..Clinical study of acupuncture combined with exercise imagination therapy on cognitive dysfunction after stroke[J].,2020,(8):983.[doi:DOI:10.3969/j.issn.10007369.2020.07.044]
[7]叶 妮,王 钢,温大平,等.早期中医康复介入对脑出血患者功能及生活能力恢复的影响[J].陕西中医,2020,(9):1205.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.007]
[8]吴若辉,孙立君,王岚萱,等.加味芍药甘草汤、针刺联合肌电生物反馈治疗脑卒中肩手综合征疗效及对患者生活质量的影响[J].陕西中医,2020,(9):1215.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.010]
[9]邓业川,赵敏明.温针灸、浮针及针刺治疗膝骨性关节炎临床研究*[J].陕西中医,2020,(10):1496.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.044]
　DENG Yechuan,ZHAO Minming..Clinical study on the treatment of knee osteoarthritis with warm acupuncture,floating needle and acupuncture[J].,2020,(8):1496.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.044]
[10]杨 峥,高 静.神经阻滞联合埋线治疗神经根型颈椎病疗效观察[J].陕西中医,2021,(1):112.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.031]

备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研项目(2021381)
更新日期/Last Update: 2021-08-09