[1]马玉娟,何乾超,高玉广,等.mTOR通路对癫痫的影响及中医药干预作用研究进展[J].陕西中医,2021,(8):1147-1149,封3.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.039]
　MA Yujuan,HE Qianchao,GAO Yuguang,et al.Research progress on the effects of mTOR pathway on epilepsy and Chinese medicine intervention[J].,2021,(8):1147-1149,封3.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.039]
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mTOR通路对癫痫的影响及中医药干预作用研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年8期
页码:
1147-1149,封3
栏目:
综 述
出版日期:
2021-08-05

文章信息/Info

Title:
Research progress on the effects of mTOR pathway on epilepsy and Chinese medicine intervention
作者:
马玉娟1; 何乾超2; 高玉广2; 蔡 伦2
(1.广西中医药大学,广西 南宁 530001; 2.广西中医药大学第一附属医院,广西 南宁 530023)
Author(s):
MA Yujuan; HE Qianchao; GAO Yuguang; CAI Lun
(Guangxi University of Traditional Chinese Medicine,Nanning 530001,China)
关键词:
癫痫;  雷帕霉素靶蛋白;  细胞凋亡;  细胞自噬;  突触可塑性
Keywords:
Epilepsy;  mTOR;  Cell apoptosis;  Cell Autophagy;  Synaptic plasticity
分类号:
R 742.1
DOI:
DOI:10.3969/j.issn.1000-7369.2020.08.039
文献标志码:
A
摘要:
癫痫是常见的神经系统疾病,其发病机制复杂,病理改变亦多样化,以海马神经元细胞凋亡、胶质细胞增生、苔藓纤维出芽等为主要病理表现。近年来,国内外对于抗癫痫治疗专注于分子水平及其信号通路的研究,其中哺乳动物雷帕霉素靶蛋白(mTOR)这一信号通路通过细胞生长增殖、蛋白质代谢、细胞凋亡自噬、突触可塑性等对抗癫痫发挥重要的作用。中医药在治疗癫痫上疗效明显,大量实验证明中医药干预,包括中药单体、中药复方等治疗,能够通过mTOR信号通路发挥抗癫痫作用,从而减少癫痫发作频率、保护神经元细胞、改善癫痫症状等。mTOR信号通路也成为中医药治疗癫痫的重要靶点。现综述mTOR通路对癫痫的影响及中医药干预作用的研究进展。
Abstract:
Epilepsy is a common nervous system disease.Its pathogenesis is complex,but also pathological changes are diverse.pathological manifestations are mainly hippocampal neuronal cell apoptosis,glial cell proliferation,mossy fiber budding and so on.Recently,antiepileptic therapy has focused on molecular levels and its signaling pathways at home and abroad,in which mammalian rapamycin target protein(mTOR)plays an important role in combating epilepsy through cell growth appreciation,protein metabolism,apoptotic autophagy,synaptic plasticity,and so on.Chinese medicine has obvious curative effect in the treatment of epilepsy.A large number of experiments have proved that Chinese medicine intervention,including Chinese medicine monomer,Chinese medicine compound treatment,can play an anti-epileptic effect through mTOR signaling pathway,thus reducing the frequency of epileptic seizures,protecting neuronal cells,improving epileptic symptoms and so on.mTOR signaling pathway has also become an important target for the treatment of epilepsy by traditional Chinese medicine.A review on the effects of mTOR pathway on epilepsy and the intervention of traditional Chinese medicine is presented.

参考文献/References:

[1] 涂雪松.癫痫的流行病学研究[J].脑与神经疾病杂志,2017,25(8):522-529.
[2] 陆 波,潘凉泽,谢延风.mTOR信号通路与癫痫的发生发展[J].中国神经精神疾病杂志,2013,39(11):695-698.
[3] 曾玲晖,丁美萍.mTOR信号通路在癫痫发生中的作用[J].浙江大学学报:医学版,2013,42(6):597-601.
[4] Cho CH.Frontier of epilepsy research-mTOR signaling pathway[J].Exp Mol Med,2011,43(5):231-274.
[5] 常燕燕,单 敏,杨 申.mTOR信号通路与癫痫研究进展[J].中华临床医师杂志,2016,19(10):2917-2920.
[6] Zhang HY,Tao JY,Zhang SX,et al.LncRNA MEG3 reduces hippocampal neuron apoptosis via the PI3K/AKT/mTOR pathway in a rat model of temporal lobe epilepsy[J].Neuropsychiatric Disease and Treatment,2020,28(16):2519-2528.
[7] Liu AH,Chu M,Wang YP.Up-Regulation of trem2 inhibits hippocampal neuronal apoptosis and alleviates oxidative stress in epilepsy via the PI3K/Akt pathway in mice[J].Neurosci Bull,2019,35(3):471-485.
[8] Zeng LH,Mcdaniel S,Rensing NR,et al.Regulation of cell death and epileptogenesis by the mammalian target of rapamycin(mTOR):A double-edged sword?[J].Cell cycle(Georgetown,Tex),2010,9(12):2281-2285.
[9] Goto J,Talos DM,Klein P,et al.Regulable neural progenitor-specific tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(45):1070-1079.
[10] Lin JY,Fang YX,Zhang MC,et al.Phosphorylation of PRAS40 contributes to the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of autophagy following status epilepticus in rats[J].Exp Ther Med,2020,20(4):3625-3632.
[11] Mcmahon J,Huang XX,Yang J,et al.Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,2012,32(45):15704-15714.
[12] Parkinson GT,Hanley JG.Mechanisms of AMPA receptor endosomal sorting[J].Frontiers in Molecular Neuroscience,2018,11(4):40-55.
[13] Bateup HS,Takasaki KT,Saulnier JL,et al.Loss of tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,2011,31(24):8862-8869.
[14] Lisi L,Navarra P,Feinstein DL,et al.The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes[J].Journal of Neuroinflammation,2011,8(1):1-11.
[15] Wang XQ,Sha LZ,Sun NN,et al.Deletion of mTOR in reactive astrocytes suppresses chronic seizures in a mouse model of temporal lobe epilepsy[J].Mol Neurobiol,2017,54(1):175-187.
[16] Zeng LH,Xu L,Gutmann DH,et al.Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex[J].Annals of Neurology,2010,63(4):444-453.
[17] Brewster AL,Lugo JN,Patil VV,et al.Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage[J].PLoS One,2013,8(3):57808-57825.
[18] Li Z,You ZY,Li M,et al.Protective effect of resveratrol on the brain in a rat model of epilepsy[J].Neurosci Bull,2017,33(3):273-280.
[19] Liu ML,Wilk SA,Wang AP,et al.Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and deptor[J].Journal of Biological Chemistry,2010,285(47):36387-36394.
[20] 方玲玲,唐久来,吴 德,等.张杰辨治小儿难治性癫痫经验总结[J].陕西中医,2020,41(9):1292-1294.
[21] 陆 波,谢延风,石全红,等.姜黄素通过抑制外伤性癫痫鼠脑组织中mTORC1的表达发挥抗癫痫效应[J].第三军医大学学报,2015,37(5):414-419.
[22] 王 娜,佟凤芝,曾常茜.姜黄素对海人酸致痫大鼠PI3K/AKt/mTOR通路调节作用的实验研究[J].中国中医药科技,2015,22(5):534-536,549.
[23] Ye M,Bi YF,Ding L,et al.Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway[J].Biomedicine & Pharmacotherapy,2016,81(4):281-287.
[24] 吴 靖,周宏斌,潘松青.莲心碱对氯化锂-匹鲁卡品致癫模型急性期皮层脑电图的影响[J].安徽医药,2016,20(3):449-453.
[25] 羊小华,吴百威,何 炜,等.莲心碱对七氟烷诱发新生大鼠皮层癫痫样脑电图波的影响[J].中国临床药理学杂志,2020,36(17):2679-2681.
[26] 杨 滨.黄芩苷通过PI3K/Akt/mTOR通路上调癫痫大鼠海马自噬活性及其神经保护作用的研究[D]. 福州:福建医科大学,2019.
[27] 陈惠军,李志萍,元芳芳,等.百合知母汤对癫痫模型幼鼠行为学和海马神经发生及AMPK/mTOR水平的影响[J].毒理学杂志,2019,33(1):38-43.
[28] 汪顺贵,玉 倩,李华霞,等.加味柴胡疏肝汤调控miR-204对急性癫痫小鼠海马AKT/mTOR/P70S6K通路和脑电图的影响[J].时珍国医国药,2020,31(2):273-276.
[29] 张冰冰,齐 越,韦 丹,等.癫痫清颗粒对海人藻酸癫痫大鼠脑组织氨基酸类神经递质含量及学习记忆能力的影响[J].中华中医药学刊,2016,34(3):609-611.
[30] 汝文娟.谷氨酸诱导的神经元突触活动对mTOR信号通路的调节[D]. 湛江:广东医学院,2010.
[31] 贾东佩,李春雷.穴位埋线治疗难治性癫痫疗效及对血清GAL、PGP、MBP的影响[J].陕西中医,2019,40(4):528-530.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(8196150126); 广西壮族自治区自然科学基金资助面上项目(2019JJA140204); 广西高等学校高水平创新团队及卓越学者计划项目[桂教人才(2020)6号]; 广西中医药大学“岐黄工程”高层次人才团队培育项目(2018003); 广西中医药大学第一附属医院学术团队建设项目[院字(2018)146号]
更新日期/Last Update: 2021-08-09