[1]于得海,毛真真,燕玉敏,等.调肺汤合解郁攻坚汤治疗肺小结节合并抑郁障碍临床研究[J].陕西中医,2021,(11):1568-1571.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.017]
　YU Dehai,MAO Zhenzhen,YAN Yumin,et al.Observation on the clinical efficacy of Tiaofei decoction and Jieyu Gongjian decoction in treating pulmonary nodules with depression[J].,2021,(11):1568-1571.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.017]
点击复制

调肺汤合解郁攻坚汤治疗肺小结节合并抑郁障碍临床研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年11期
页码:
1568-1571
栏目:
临床研究
出版日期:
2021-11-05

文章信息/Info

Title:
Observation on the clinical efficacy of Tiaofei decoction and Jieyu Gongjian decoction in treating pulmonary nodules with depression
作者:
于得海1; 2; 毛真真1; 燕玉敏1; 潘智慧1; 王 凯1; 贾在金1
(1.滨州市中医医院,山东 滨州 256613; 2.滨州医学院,山东 烟台 264033)
Author(s):
YU Dehai;  MAO Zhenzhen; YAN Yumin; PAN Zhihui; WANG Kai; JIA Zaijin
(Binzhou Hospital of Traditional Chinese Medicine,Binzhou 256613,China)
关键词:
肺小结节;  调肺汤;  解郁攻坚汤;  抑郁障碍;  生存质量;  肺功能
Keywords:
Pulmonary nodules;  Tiaofei decoction;  Jieyu Gongjian decoction;  Depressive disorder;  Quality of life;  Lung function
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.017
文献标志码:
A
摘要:
目的:分析调肺汤合解郁攻坚汤治疗肺小结节合并抑郁障碍的临床疗效。方法:随机抽取80例肺小结节合并抑郁障碍患者,依据随机数字表法分为两组,对照组40例予以盐酸氟西汀治疗,观察组40例予以调肺汤合解郁攻坚汤治疗,疗程结束后对比两组中医疗效、生存质量、肺功能水平、情绪状态及预后水平。结果:观察组治疗后中医疗效为95.00%,比对照组的77.50%高(P<0.05); 观察组的生存质量有效率为97.50%,比对照组的80.00%高(P<0.05); 观察组治疗后的第1秒用力呼吸容积(FEV1)及其FEV1/用力肺活量(FVC)均高于治疗前,且高于对照组(P<0.05); 观察组治疗后的焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分均低于治疗前,且低于对照组(P<0.05); 观察组治疗后日常生活活动能力量表(ADL)评分及功能独立性测量量表(FIM)评分均比对照组高(P<0.05)。结论:中药调肺汤合解郁攻坚汤治疗肺小结节合并抑郁障碍的临床疗效显著,有助于提高患者生存质量,并且促进其肺功能水平、情绪状态及预后水平改善。
Abstract:
Objective:To analyze the clinical efficacy of Tiaofei decoction and Jieyu Gongjian decoction in the treatment of small pulmonary nodules with depression.Methods:80 cases of small pulmonary nodules and depressive disorder patients were selected,randomly divided into two groups according to the random number table method.40 cases in the control group were treated with fluoxetine hydrochloride,and 40 cases in the observation group were treated with Tiaofei decoction and Jieyu Gongjian decoction,the efficacy,quality of life,lung function,emotional state and prognosis of the two groups were compared after the course of treatment.Results:In the observation group,the effect of traditional Chinese medicine after treatment was 95.00%,which was higher than 77.50% in the control group(P<0.05).In the observation group,the effective rate of quality of life after treatment was 97.50%,which was higher than 80.00% in the control group(P<0.05).In the observation group,the FEV1 and FEV1/FVC after treatment were higher than before treatment,and higher than the control group(P<0.05).In the observation group,the SAS score and SDS score after treatment were lower than before treatment,and lower than the control group(P<0.05).In the observation group,the ADL score and FIM score after treatment were higher than the control group(P<0.05).Conclusion:Tiaofei decoction and Jieyu Gongjian decoction have significant clinical effects in the treatment of pulmonary nodules with depression,which can help to improve the quality of life of patients,as well as promote the improvement of their lung function level,emotional state and prognosis.

参考文献/References:

[1] Marcus MW,Duffy SW,Devaraj A,et al.Probability of cancer in lung nodules using sequential volumetric screening up to 12 months:The UKLS trial[J].Thorax,2019,74(8):761-767.
[2] 张晓菊.《肺结节诊治中国专家共识(2018版)》解读[J].中华实用诊断与治疗杂志,2019,33(1):7-9.
[3] 吴明君,王向东,陈 瑜,等.肺部小结节患者随访及转归研究[J].中国肿瘤临床与康复,2019,26(6):716-718.
[4] 王浩宇.初诊肺结节患者伴发抑郁情绪的研究及干预[D].大连:大连医科大学,2019.
[5] 夏逸飞,孙子凯,丁振洋,等.从偏颇体质论孤立性肺结节的中医辨治[J].广州中医药大学学报,2019,36(8):1267-1271.
[6] 许海柱,祝佳佳,张 栩,等.基于聚类分析和因子分析的肺小结节患者中医证候特点研究[J].中国中医药信息杂志,2020,27(2):84-87.
[7] 中华医学会精神科分会.中国精神障碍分类与诊断标准第三版(CCMD-3)[M].济南:山东科学技术出版社,2001:118-119.
[8] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:23-24.
[9] 巫小云,张 丽,王甜甜.清金化痰汤辅助治疗肺癌合并肺部感染的效果及对KPS评分的影响[J].癌症进展,2019,17(10):1208-1211.
[10] 陶 明,高静芳.修订焦虑自评量表的信度及效度[J].中国神经精神疾病杂志,1994,20(5):301-303.
[11] 戴晓阳.常用心理评估量表手册[M].北京:人民军医出版社,2013:153-156.
[12] Han DS,Chang PW,Chu EC.Effect of home-based reablement program on improving activities of daily living for patients with stroke:A pilot study[J].Medicine,2020,99(49):23512.
[13] Hamilton BB,Laughlin JA,Fiedler RC,et al.Inter-rater reliability of the seven level functional independence measure(FIM)[J].Scand J Rehabil Med,1994,26(3):115-119.
[14] 王彦锋,李月考,王光大,等.CT引导下肺穿刺对肺小结节的诊疗价值[J].河北医药,2017,39(15):2359-2361.
[15] 刘本刚,张建伟,王继云,等.全胸腔镜辅助下行解剖性肺段切除术治疗肺部小结节疗效观察[J].陕西医学杂志,2017,46(2):178-179,237.
[16] 周 围,胡富碧,刘亚斌,等.基于AI对肺小结节CT图像层厚与结节特征的检出效能影响[J].医学影像学杂志,2021,31(2):234-238.
[17] 余 杰,曹 炜,顾江魁,等.肺结节定位针与Hookwire在周围型孤立性肺小结节术前定位中的应用比较[J].临床肺科杂志,2021,26(2):293-295.
[18] 段国敏,杜海峰,金 辉.64排螺旋CT高级分析软件在肺小结节良恶性中的诊断价值[J].河北医药,2012,34(18):2809.
[19] 朱北林,蒋 涛,彭 朋.肺小结节影像诊断研究进展[J].中国病案,2019,20(2):94-98.
[20] 许海柱,祝佳佳,张 栩,等.肺小结节患者中医证型与临床指标相关性研究[J].国际中医中药杂志,2020,42(6):524-529.

备注/Memo

备注/Memo:
基金项目:山东省中医药科技发展计划项目(2019-0915)
更新日期/Last Update: 2021-11-10