[1]易宏英,赵清平,陈德新.糠酸莫米松乳膏辅以苦参止痒汤治疗外阴硬化性苔藓临床研究[J].陕西中医,2021,(11):1572-1575.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.018]
　YI Hongying,ZHAO Qingping,CHEN Dexin.Clinical study of mometasone furoate cream supplemented combined with Kushen Zhiyang decoction in the treatment of vulvar lichen sclerosus[J].,2021,(11):1572-1575.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.018]
点击复制

糠酸莫米松乳膏辅以苦参止痒汤治疗外阴硬化性苔藓临床研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年11期
页码:
1572-1575
栏目:
临床研究
出版日期:
2021-11-05

文章信息/Info

Title:
Clinical study of mometasone furoate cream supplemented combined with Kushen Zhiyang decoction in the treatment of vulvar lichen sclerosus
作者:
易宏英; 赵清平; 陈德新
(四川省妇幼保健院,四川 成都 610031)
Author(s):
YI Hongying; ZHAO Qingping; CHEN Dexin
(Sichuan Province Maternity and Child Health Hospital,Chengdu 610031,China)
关键词:
外阴硬化性苔藓;  外治法;  糠酸莫米松乳膏;  苦参止痒汤;  生活质量
Keywords:
Vulvar lichen sclerosus;  External treatment method;  Mometasone furoate cream;  Kushen Zhiyang decoction;  Quality of life
分类号:
R 711.72
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.018
文献标志码:
A
摘要:
目的:探讨糠酸莫米松乳膏辅以苦参止痒汤治疗外阴硬化性苔藓的临床疗效。方法:将64例经病理组织学诊断为外阴硬化性苔藓的患者随机分为治疗组和对照组各32例,治疗组采用苦参止痒汤熏洗联合糠酸莫米松乳膏外用治疗,1次/d,共4周,然后隔日1次,持续4周,最后每周2次,持续4周,共3个月为1个疗程,对照组单用糠酸莫米松乳膏外用治疗,共3个月为1个疗程,观察两组治疗前后外阴瘙痒、外阴皮肤病变范围、外阴皮肤颜色、弹性及生活质量的变化情况,并停药3个月后比较两组疾病的复发率。结果:治疗3个月后,两组外阴瘙痒评分、外阴皮肤病变范围评分、外阴皮肤颜色、弹性评分均降低,组间比较差异无统计学意义(P>0.05); 两组生活质量评分均升高,但治疗组高于对照组,组间比较差异有统计学意义(P<0.05); 在临床疗效方面比较,两组疗效相当,治疗组治愈率为93.75%,对照组治愈率为87.50%,组间比较差异无统计学意义(P>0.05); 停药3个月,治疗组复发率12.50%,对照组复发率为37.50%,组间比较差异有统计学意义(P<0.05); 不良反应比较,治疗组发生率为3%,对照组发生率为9%,组间比较差异有统计学意义(P<0.05)。结论:糠酸莫米松乳膏辅以苦参止痒汤治疗外阴硬化性苔藓疗效好,安全、复发率低。
Abstract:
Objective:To explore the clinical efficacy of mometasone furoate cream supplemented with Kushen Zhiyang decoction in the treatment of vulvar lichen sclerosus.Methods:64 patients with vulvar lichen sclerosus diagnosed by histopathology were randomly divided into a treatment group and a control group,each with 32 cases.The treatment group was treated with Kushen Zhiyang decoction fumigation combined with mometasone furoate cream for topical treatment,and finally 2 times a week,lasting 4 weeks,a total of 3 months as a course of treatment.The control group was treated with mometasone furoate cream alone,a total of 3 months as a course of treatment.Observe the two groups before and after treatment,the extent of vulvar skin lesions,the color and elasticity of vulva skin and the changes in the quality of life,and compare the recurrence rates of the two groups of diseases three months after stopping the drug.Results:After 3 months of treatment,the vulvar pruritus score,vulvar skin lesion score,vulvar skin color,and elastic score decreased in the two groups,and there was no significant difference between the groups(P>0.05); the quality of life scores of the two groups increased high,but the treatment group is higher than the control group.The difference between the groups is statistically significant(P<0.05); in terms of clinical efficacy,the two groups have the same efficacy.The cure rate of the treatment group is 93.75%,and the cure rate of the control group is 87.50%,the difference between the groups was not statistically significant(P>0.05); after stopping the drug for 3 months,the recurrence rate of the treatment group was 12.50%,and the recurrence rate of the control group was 37.50%.The difference between the groups was statistically significant(P<0.05).Comparison of adverse reactions,the incidence of treatment group was 3%,the incidence of control group was 9%,the difference between the groups was statistically significant(P<0.05).Conclusion:Mometasone furoate cream supplemented with Kushen Zhiyang decoction has good curative effect,safety and low recurrence rate in the treatment of vulvar lichen sclerosus.

参考文献/References:

[1] 刘懋毓,常淑芳.外阴硬化性苔藓诊疗进展[J].世界最新医学信息文摘,2020,20(19):149-151.
[2] 唐苏为,谢韶琼.皮肤瘙痒程度评价方法进展[J].中国皮肤性病学杂志,2016,30(1):84-85.
[3] 朱丽君,胡 君.女性外阴硬化性苔藓临床诊治专家共识(2021年版)[J].中国实用妇科与产科杂志,2021,37(1):70-74.
[4] 刘桂兰,赵铭宇,王佳俣,等.白斑膏治疗外阴硬化性苔藓的临床疗效观察[J].中国中医药科技,2020,27(3):420-421.
[5] 谭志琼.中西医结合治疗外阴硬化性苔藓的临床应用[J].中外妇儿健康,2010,18(12):112-113.
[6] 李谊明,姜 巍,祖淑静.54例慢性外阴营养不良的临床分析[J].中国医药指南,2010,8(12):101-102.
[7] 谢 幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:241-243.
[8] 高巧连,齐 进,梁慧芳.聚焦超声治疗外阴白色病变253例[J].陕西医学杂志,2012,41(1):83-84.
[9] 马俊莲.中药熏洗对外阴硬化性苔藓治疗的疗效影响[J].河北中医药学报,2016,31(1):25-27.
[10] 周 欣,陆景明.外阴硬化性苔藓的诊治[J].中国实用妇科与产科杂志,2004,20(11):647.
[11] 蒋海娟.得宝松联合利多卡因治疗外阴硬化性苔藓疗效观察[J].吉林医学,2011,32(33):7076-7077.
[12] 东 敏.外阴白色病变的中西医结合治疗研究[D].上海:上海交通大学,2009.
[13] 汤春琼,黄 昕,周晴晴,等.滋肾养肝法治疗围绝经期及绝经后期外阴白色病变疗效研究[J].陕西中医,2019,40(1):18-20.
[14] 屈莉莉.中药内外合治治疗肝肾阴虚型外阴色素减退性疾病的临床观察[D].兰州:甘肃中医药大学,2019.
[15] 何耀华.中药熏洗疗法在肛肠疾病中的应用概况[J].中医外治杂志,2013,22(2):59-60.
[16] 郑荣慧,潘振亮.中药熏洗对肛周疾病的作用机理分析[J].辽宁中医学院学报,2005,7(3):216-217.
[17] 陈 培,李 月,刘 丽.外阴硬化性苔藓中西医治疗现状[J].世界最新医学信息文摘,2018,18(86):62-63.
[18] 靳庆丰.止痒消斑汤熏洗治疗女阴白色病变38例[J].陕西中医,2010,31(3):272.
[19] 孟庆红,张 玲,张喜云.苦参的药理研究进展[J].航空航天医药,2009,20(2):125-126.
[20] 史龙泉.女性会阴部慢性单纯性苔癣49例临床分析[J].陕西医学杂志,2011,40(10):1391-1392.

相似文献/References:

[1]倪建俐,黄 姝,袁 晴△.中医特色疗法治疗中风后肢体功能障碍研究进展*[J].陕西中医,2020,(9):1339.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.045]
[2]东 淳,孙 丹,邱馨锐,等.游走罐疗法在血瘀证银屑病中的应用研究[J].陕西中医,2021,(1):75.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.019]
[3]周莹莹,张 琼,张 迁,等.中药外洗法治疗手部湿疹研究概述[J].陕西中医,2022,(2):265.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.030]
　ZHOU Yingying,ZHANG Qiong,ZHANG Qian,et al.Summary of the research on the treatment of hand eczema with Chinese medicine washing method[J].,2022,(11):265.[doi:DOI:10.3969/j.issn.1000-7369.2022.02.030]
[4]李英宵,张开波,张璐鹏,等.针刺治疗胃食管反流病研究进展[J].陕西中医,2022,(8):1147.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.038]
　LI Yingxiao,ZHANG Kaibo,ZHANG Lupeng,et al.Research progress of acupuncture in the treatment of gastroesophageal reflux disease[J].,2022,(11):1147.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.038]
[5]杨润雨,陈 瑶,冯晓玲.中医药治疗子宫内膜异位症致不孕研究进展[J].陕西中医,2023,(5):670.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.032]
　YANG Runyu,CHEN Yao,FENG Xiaoling.Research progress of traditional Chinese medicine in the treatment of infertility caused by endometriosis[J].,2023,(11):670.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.032]
[6]黄稚真,胡 敏,梁惠卿,等.化痰祛瘀法治疗肝豆状核变性研究进展[J].陕西中医,2023,(6):815.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.030]
　HUANG Zhizhen,HU Min,LIANG Huiqing,et al.Research advance in the treatment of hepatolenticular degeneration by dispelling phlegm and removing stasis[J].,2023,(11):815.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.030]
[7]宁 静,安成飞,黄偲崟,等.针刺治疗原发性肌张力障碍研究进展[J].陕西中医,2023,(10):1491.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.036]
　NING Jing,AN Chengfei,HUANG Caiyin,et al.Advances in acupuncture treatment of primary dystonia[J].,2023,(11):1491.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.036]
[8]于文超,张涌威,王慧格,等.基于“玄府-气液-络脉”理论论治白癜风[J].陕西中医,2024,(12):1670.[doi:DOI:10.3969/j.issn.1000-7369.2024.12.018]
[9]袁 港,龚学忠.“劳淋病”古代中医药文献记载及现代治疗现状[J].陕西中医,2025,46(1):142.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.032]
　YUAN Gang,GONG Xuezhong.“Labor-induced stranguria” ancient records in traditional Chinese medicine literature and the current state of modern treatment[J].,2025,46(11):142.[doi:DOI:10.3969/j.issn.1000-7369.2025.01.032]

更新日期/Last Update: 2021-11-10