[1]王中会,晁 旭,吕天依,等.土贝母苷甲抗肿瘤作用机制研究进展[J].陕西中医,2021,(11):1652-封3.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.036]
 WANG Zhonghui,CHAO Xu,LYU Tianyi,et al.Research progress on the Anti-solid tumor mechanism of TBMSⅠ[J].,2021,(11):1652-封3.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.036]
点击复制

土贝母苷甲抗肿瘤作用机制研究进展
分享到:

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年11期
页码:
1652-封3
栏目:
综 述
出版日期:
2021-11-05

文章信息/Info

Title:
Research progress on the Anti-solid tumor mechanism of TBMSⅠ
作者:
王中会1晁 旭12吕天依1胡锦丹1闫平慧1
(1.陕西中医药大学,陕西 咸阳712046; 2.陕西中医药大学第二附属医院,陕西 咸阳 712046)
Author(s):
WANG ZhonghuiCHAO XuLYU TianyiHU JindanYAN Pinghui
(Shaanxi University of Chinese Medicine,Xi'an 712046,China)
关键词:
肿瘤 土贝母苷甲 抗癌特性 分子机制 肿瘤系统
Keywords:
Tumor Tubeimoside Ⅰ Anti-cancer properties Molecule mechanism Tumor system
分类号:
R 73
DOI:
DOI:10.3969/j.issn.1000-7369.2020.11.036
文献标志码:
A
摘要:
天然化合物是抗癌药物的重要来源。土贝母苷甲(TBMSⅠ)是土贝母的主要药理活性成分,大量实验研究证实TBMSⅠ在体内外不同的致癌阶段都具有抗癌活性。TBMSⅠ通过多种信号通路抑制癌细胞的生长和增殖,诱导细胞周期阻滞、凋亡、分化、自噬,抑制血管生成、侵袭和转移。TBMSⅠ联合化疗药治疗还可增强耐药癌细胞的敏感性。现就TBMSⅠ在各肿瘤系统中的抗肿瘤作用的临床前研究及其分子机制进行综述和分析,并对其在肿瘤防治中的应用前景进行展望。TBMSⅠ作为相关候选药物的潜力可以被适当地开发和设计成一种有效的抗癌药物。
Abstract:
Natural compounds are important sources of anticancer drugs.TubeimosideⅠ(TBMSⅠ)is the main pharmacologically active component of rhizoma bolbostemmatis.Extensive researches have provided evidences of the anticancer activities of TBMSⅠ in different stages of carcinogenesis both in vitro and in vivo model.TBMSⅠcould inhibit cell growth and proliferation,induce cell differentiation,apoptosis,autophagy and,suppress angiogenesis,invasion and metastasis via various signaling pathways.Combination of TBMSⅠ with chemotherapeutic agents also enhanced the sensitivity of drug-resistant cancer cells.This mini-review aims to summarize and analyze the current knowledge on the pre-clinical studies of anti-tumor effects,the underlying molecular mechanisms in various tumor systems and discuss the prospects of the application of TBMSⅠ in cancer prevention and treatment.The potential of TBMSⅠ as pertinent candidates could be appropriately developed and designed into an efficacious anticancer drug.

参考文献/References:

[1] Islam MS,Wang C,Zheng J,et al.The potential role of tubeimosides in cancer prevention and treatment[J].Eur J Med Chem,2019(162):109-121.
[2] 裴晓华,彭艳梅.中医药治疗恶性肿瘤70年[J].中国肿瘤外科杂志,2019,11(5):305-308.
[3] 朱晓丹,安 超,姜 敏,等.从文献角度探索中药土贝母药用源流[J].环球中医药,2018,11(6):884-886.
[4] Erridge SC,Moller H,Price A,et al.International comparisons of survival from lung cancer:Pitfalls and warnings[J].Nat Clin Pract Oncol,2007,4(10):570-577.
[5] Zhang Y,Xu X,He P.Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells[J].Mol Med Rep,2011,4(1):25-29.
[6] 苏甲林,赵参军,郑 瑾.土贝母苷甲对人肺腺癌细胞增殖及凋亡的影响[J].临床肺科杂志,2021,26(1):95-100.
[7] Hao W,Wang S,Zhou Z.Tubeimoside-1(TBMSⅠ)inhibits lung cancer cell growth and induces cells apoptosis through activation of MAPK-JNK pathway[J].Int J Clin Exp Pathol,2015,8(10):12075-12083.
[8] Lin Y,Xie G,Xia J,et al.TBMSⅠ exerts its cytotoxicity in NCI-H460 lung cancer cells through nucleolar stress-induced p53/MDM2-dependent mechanism,a quantitative proteomics study[J].Biochim Biophys Acta,2016,1864(2):204-210.
[9] Poillet PL,White E.Role of tumor and host autophagy in cancer metabolism[J].Genes Dev,2019,33(11):610-619.
[10] Wang K,Zhan Y,Chen B,et al.Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria[J].Cell Death Dis,2020,11(8):708.
[11] Gu Y,Korbel C,Scheuer C,et al.Tubeimoside-1 suppresses tumor angiogenesis by stimulation of proteasomal VEGFR2 and Tie2 degradation in a non-small cell lung cancer xenograft model[J].Oncotarget,2016,7(5):5258-5272.
[12] Shi H,Bi H,Sun X,et al.Tubeimoside-1 inhibits the proliferation and metastasis by promoting miR-126-5p expression in non-small cell lung cancer cells[J].Oncol Lett,2018,16(3):3126-3134.
[13] 王欣悦,朱雪婷,刘天赋,等.土贝母皂苷甲逆转A549/DDP细胞系耐药性的分子效应[J].基因组学与应用生物学,2020,39(8):3600-3606.
[14] Chan JY.Surgical salvage of recurrent nasopharyngeal carcinoma[J].Curr Oncol Rep,2015,17(3):433.
[15] Ma R,Song G,You W,et al.Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin[J].Cancer Chemother Pharmacol,2008,62(4):559-568.
[16] 翁昔阳,马润娣,于立坚.土贝母苷甲诱导人鼻咽癌细胞CNE-2Z凋亡[J].癌症,2003,22(8):806-811.
[17] 刘姬艳,马润娣,于立坚.土贝母苷甲对人鼻咽癌上皮细胞丝裂原活化蛋白激酶活性的影响[J].北京中医,2007,27(2):119-121.
[18] Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[19] Wang Y,Deng L,Zhong H,et al.Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma(HepG2)cells[J].Biol Pharm Bull,2011,34(6):831-838.
[20] Peter ME,Krammer PH.The CD95(APO-1/Fas)DISC and beyond[J].Cell Death Differ,2003,10(1):26-35.
[21] Yin Y,Chen W,Tang C,et al.NF-kappaB,JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G2/M cell cycle arrest[J].Food Chem Toxicol,2011,49(12):3046-3054.
[22] Cheng J,Zhang T,Ji H,et al.Functional characterization of AMP-activated protein kinase signaling in tumorigenesis[J].Biochim Biophys Acta,2016,1866(2):232-251.
[23] Kabeya Y,Mizushima N,Ueno T,et al.LC3,a mammalian homologue of yeast Apg8p,is localized in autophagosome membranes after processing[J].The EMBO Journa,2000,19(21):5720-5728.

相似文献/References:

[1]黄越秀,陈光伟,张家墉△,等.陈光伟教授治疗肿瘤根治术后肠麻痹经验[J].陕西中医,2020,(11):1654.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.036]
[2]曾普华.从炎性微环境探析肿瘤恶液质的“癌毒致虚”病机观[J].陕西中医,2021,(8):987.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.001]
 ZENG Puhua.Analysis of the “cancer toxin-induced deficiency” pathogenesis of tumor cachexia from the inflammatory microenvironment[J].,2021,(11):987.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.001]
[3]张小力,刘 芹,刘宝瑞.重楼皂苷抗肿瘤及调节肿瘤免疫微环境研究进展[J].陕西中医,2021,(11):1640.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.033]
 ZHANG Xiaoli,LIU Qin,LIU Baorui.Advances in anti-tumor effects of paris saponins[J].,2021,(11):1640.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.033]
[4]张美英,张 英,侯 炜.基于数据挖掘探讨黄芪抗肿瘤复方的临床应用[J].陕西中医,2023,(7):957.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.031]
[5]冯薪宇,罗富锟,胡利来,等.肿瘤中医病机发展与“辨病识机”指导意义[J].陕西中医,2025,46(2):237.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.019]
 FENG Xinyu,LUO Fukun,HU Lilai,et al.The innovative development of TCM tumor pathogenesis and the guiding significance of “disease identification machine”[J].,2025,46(11):237.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.019]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81774132); 陕西省科技计划项目(2020SF-324); 陕西中医药大学消化病肿瘤分子机制及中西医结合防治基础研究创新团队课题(2019-YS05)
更新日期/Last Update: 2021-11-10