[1]王 鹏,符 磊,陈 浪,等.加味清营汤对寻常型银屑病血热证患者炎症因子及免疫功能的影响[J].陕西中医,2021,(12):1709-1712.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.014]
　WANG Peng,FU Lei,CHEN Lang,et al.Effect of modified Qingying decoction on inflammatory factor and immune function in patients with psoriasis vulgaris of Xuere syndrome[J].,2021,(12):1709-1712.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.014]
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加味清营汤对寻常型银屑病血热证患者炎症因子及免疫功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年12期
页码:
1709-1712
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Effect of modified Qingying decoction on inflammatory factor and immune function in patients with psoriasis vulgaris of Xuere syndrome
作者:
王 鹏; 符 磊; 陈 浪; 李梅娇; 林少妃
(海南省中医院皮肤性病科,海南 海口 570203)
Author(s):
WANG Peng; FU Lei; CHEN Lang; LI Meijiao; LIN Shaofei
(Department of Dermatology and Venereology,Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570203,China)
关键词:
银屑病;  血热证;  清营汤;  巨噬细胞集落刺激因子;  血管内皮生长因子;  白介素-17;  免疫功能
Keywords:
Psoriasis vulgaris;  Xuere syndrome;  Qingying decoction;  Macrophage colony-stimulating factor;  Vascular endothelial growth factor;  Interleukin-17;  Immune function
分类号:
R 758.63
DOI:
DOI:10.3969/j.issn.1000-7369.2020.12.014
文献标志码:
A
摘要:
目的:探讨加味清营汤在寻常型银屑病血热证患者治疗中的应用价值,观察其对炎症因子、免疫功能的影响。方法:采用随机数字表法将98例寻常型银屑病血热证患者分为对照组和观察组。对照组49例采用西医常规治疗,观察组49例在对照组基础上联合加味清营汤治疗。治疗后比较两组巨噬细胞集落刺激因子(M-CSF)、血管内皮生长因子(VEGF)、白介素-6(IL-6)、白介素-17(IL-17)、CD4+、CD3+、CD4+/CD8+、银屑病皮损面积及严重程度指数(PASI)评分,比较两组疗效及不良反应发生情况。结果:治疗后观察组血清M-CSF、VEGF水平低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组血清IL-6、IL-17水平低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组血清CD4+、CD3+、CD4+/CD8+、水平低于对照组(均P<0.05)。治疗后观察组第2周、第4周时PASI评分低于对照组,差异有统计学意义(均P<0.05)。治疗后观察组总有效率93.88%,高于对照组的73.47%,差异有统计学意义(P<0.05)。观察组不良反应发生率14.29%高于对照组的12.24%,差异无统计学意义(P>0.05)。结论:加味清营汤联合西药治疗寻常型银屑病血热证患者可抑制炎症反应,调节免疫功能,抑制血管新生,改善患者症状,疗效较好。
Abstract:
Objective:To explore application value of modified Qingying decoction in the treatment of patients with psoriasis vulgaris of Xuere syndrome and observe its effect on inflammatory factor and immune function.Methods:98 patients with psoriasis vulgaris of Xuere syndrome were divided into the control group and the observation group by random number table method.49 cases in the control group were treated with conventional western medicine,and 49 cases in the observation group were treated on the basis of the control group combined with modified Qingying decoction.After treatment,the serum macrophage colony-stimulating factor(M-CSF),vascular endothelial growth factor(VEGF),interleukin-6(IL-6),interleukin-17(IL-17),CD4+,CD3+,CD4+/CD8+,psoriasis skin lesion area and severity index(PASI),adverse reaction rate and effect were compared between the two groups.Results:After treatment,the serum M-CSF and VEGF levels of the observation group were significantly lower than those in the control group(all P<0.05).After treatment,the serum interleukin-6(IL-6)and interleukin-17(IL-17)levels of the observation group were significantly lower than those in the control group(all P<0.05).After treatment,the serum CD4+,CD3+,CD4+/CD8+ levels of the observation group were lower than those in the control group(all P<0.05).After treatment,the PASI score at the second week and the forth week of the observation group were significantly lower than those in the control group(all P<0.05).The total effective rate of the observation group was 93.88% significantly higher than that in the control group 73.47%(P<0.05).The total rate of adverse reactions in the observation group was 14.29% higher than that in the control group 12.24%,difference not statistically significant(P>0.05).Conclusion:Modified Qingying decoction combined with western medicine has remarkable effect on patients with psoriasis vulgaris of Xuere syndrome,which can inhibit inflammatory response,regulate immune function,inhibit angiogenesis,improve patient's symptoms,and adverse reactions.

参考文献/References:

[1] 冯小燕,徐丽敏.寻常型银屑病遗传流行病学分析[J].中国城乡企业卫生,2019,34(3):4-6.
[2] 曹丽楠.凉血消银汤联合复方芩柏软膏对进行期银屑病患者的疗效及血清TNF-α、IL-1、IL-6的影响[J].世界中西医结合杂志,2018,13(12):1707-1710.
[3] 陈艳明,李勇坚,刘金娟,等.VEGF、PEDF在寻常型银屑病组织中的表达及与微血管密度的关系[J].皮肤病与性病,2019,41(3):318-320.
[4] 陈 曦,张凯辉,安军艳,等.寻常型银屑病患者三大基本中医证型外周血Th细胞分化与JAK/STAT信号通路的关系[J].中华中医药杂志,2019,34(12):5964-5967.
[5] 中国医师协会皮肤科医师分会中西医皮肤科亚专业委员会.中成药治疗寻常性银屑病专家共识[J].中华皮肤科杂志,2014,47(3):215-216.
[6] 国家中医药管理局.中药新药临床指导原则[M].北京:中国医药科技出版社,2002:162-167.
[7] 王 苹,唐 燕.银屑病PASI评分系统的设计与实现[J].中国医药导报,2017,14(15):179-182.
[8] 张香坡,李燕娜,李咏梅.疏风解毒胶囊治疗寻常型点滴状银屑病(风热血毒证)的疗效观察[J].中国中医急症,2020,29(1):133-135.
[9] 孙 田,王 强,王 东.复方氟米松联合卡泊三醇软膏与UVA1光疗治疗甲银屑病的疗效及不良反应分析[J].河北医学,2019,25(12):2067-2071.
[10] 朴莉玲,张春韶,唐 妮,等.寻常型银屑病患者血清IL-4、IL-8、TNF-α水平、T细胞亚群结构与患者预后转归的关系[J].海南医学院学报,2019,25(14):1096-1099.
[11] 宋印娥,李 锋,李雅琴,等.养血通络中药治疗斑块型银屑病疗效及对IL-6、TNF-α、VEGF的影响[J].现代中西医结合杂志,2017,26(21):2298-2301.
[12] 郑锦仁,李 静,赵淑珍.寻常性银屑病患者血清IL-17和IL-22的水平与皮损面积和严重程度指数的相关性[J].临床检验杂志,2019,8(2):157-158.
[13] 张凯辉,张润田,段行武,等.“消银解毒颗粒”对银屑病血热证外周血T细胞亚群Th17及其相关炎性反应因子调控作用的研究[J].世界中医药,2019,14(4):891-894.
[14] 孔丹暘.清热凉血方治疗寻常型银屑病(血热症)疗效及对相关细胞因子水平的影响[J].中医药信息,2019,36(1):49-53.
[15] 蔡艳梅,张军民,颜振民,等.蔡氏消银方对寻常型银屑病患者血清中MCP-1、M-CSF与MIP-1α表达水平的影响[J].临床合理用药杂志,2015,8(1):107-108.
[16] 秦 涛,何丽娜.芩珠凉血方配合NB-UVB治疗寻常型银屑病血热证疗效及对其T淋巴细胞亚群和MCP-1、M-CSF水平的影响[J].中国中西医结合皮肤性病学杂志,2019,18(2):127-131.
[17] 颜令义,哈 达,张美琼.银屑胶囊联合阿维A治疗寻常型银屑病临床效果及对外周血T淋巴细胞免疫功能影响[J].皮肤病与性病,2019,41(3):440-441.
[18] 李玉秋,靳峰阳,徐文英,等.甲砜霉素与阿维A对泛发性脓疱型银屑病患者血清IL-4、IL-10、IFN-γ及T淋巴细胞免疫功能的影响[J].现代中西医结合杂志,2020,29(9):975-978.
[19] 张朝晖.消银汤对寻常型银屑病血热证患者免疫功能的影响[J].上海中医药杂志,2017,51(9):72-73,77.
[20] 李 迎,宋 宇,张天琦,等.外周血T淋巴细胞亚群变化量在寻常型银屑病中的相对危险性研究[J].中国实验诊断学,2019,23(7):1177-1180.
[21] 殷文浩,金梦祝,丁韧烨.寻常型银屑病患者血清HPA和VEGF水平检测及与PASI 评分的相关性分析[J].中国中西医结合皮肤性病学杂志,2018,17(5):395-397.
[22] 孙 娟,李佳星,王 平,等.黄连膏封包联合淀粉浴对寻常型银屑病的干预疗效研究[J].中国中西医结合皮肤性病学杂志,2020,19(6):560-563.
[23] 贾金靖,莫秀梅,晏烽根,等.丹参素对银屑病小鼠皮损Yes相关蛋白的影响[J].中华中医药杂志,2020,35(11):5783-5786.
[24] 陈 乾,任潇潇,韩 丹,等.通腑清营汤对脓毒症急性肺损伤大鼠Fas及肿瘤坏死因子-α水平的影响[J].中国中医药信息杂志,2019,26(12):40-44.

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备注/Memo

备注/Memo:
基金项目:国家中医药管理局中医药标准化项目[SATCM-2015-BZ(194)]
更新日期/Last Update: 2021-12-09