[1]杨 薇,蔡新妤,高冉冉,等.丹参多酚酸注射液联合阿托伐他汀钙片治疗脑梗死疗效及对患者血液流变学影响[J].陕西中医,2022,(3):334-337.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.015]
　YANG Wei,CAI Xinyu,GAO Ranran,et al.Effect of salvia miltiorrhiza polyphenolic acid injection combined with atorvastatin calcium tablets on cerebral infarction and its effect on hemorheology[J].,2022,(3):334-337.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.015]
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丹参多酚酸注射液联合阿托伐他汀钙片治疗脑梗死疗效及对患者血液流变学影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年3期
页码:
334-337
栏目:
临床研究
出版日期:
2022-03-05

文章信息/Info

Title:
Effect of salvia miltiorrhiza polyphenolic acid injection combined with atorvastatin calcium tablets on cerebral infarction and its effect on hemorheology
作者:
杨 薇; 蔡新妤; 高冉冉; 朱国华
(新疆医科大学第一附属医院,新疆 乌鲁木齐 830011)
Author(s):
YANG Wei; CAI Xinyu; GAO Ranran; ZHU Guohua
(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)
关键词:
脑梗死;  丹参多酚酸注射液;  阿托伐他汀钙片;  血液流变学;  血脂
Keywords:
rebral infarction;  Salvia miltiorrhiza polyphenolic acid injection;  Atorvastatin calcium tablets;  Hemorheology;  Blood lipid
分类号:
R 255.2
DOI:
DOI:10.3969/j.issn.1000-7369.2022.03.015
文献标志码:
A
摘要:
目的:探讨丹参多酚酸注射液联合阿托伐他汀钙片治疗脑梗死疗效及对患者血液流变学的影响。方法:选取脑梗死患者126例,通过摸球法将患者随机分为对照组(n=63)、观察组(n=63)。两组患者均接受脑梗死常规治疗,对照组给予阿托他汀钙片治疗,观察组在对照组基础上联合使用丹参多酚酸注射液治疗。比较两组患者疗效、血液流变学指标、血脂指标、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力量表(ADL)评分及不良反应。结果:治疗后,观察组TG、HDL-C、TC水平均低于对照组,HDL-C水平高于对照组,差异有统计学意义(均P<0.05)。观察组血浆比黏度、全血高切黏度、全血低切黏度、纤维蛋白原、血细胞比容低于对照组,差异有统计学意义(均P<0.05)。观察组NIHSS评分低于对照组,ADL评分高于对照组,差异有统计学意义(均P<0.05)。观察组治疗总有效率为96.83%,高于对照组的84.13%,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:丹参多酚酸注射液联合阿托伐他汀钙片治疗脑梗死疗效较好,可有效改善血脂及血流动力学指标,提高患者神经功能及生活质量,且安全性较好。
Abstract:
Objective:To explore effect of salvia miltiorrhiza polyphenolic acid injection combined with atorvastatin calcium tablets on patients with cerebral infarction and on hemorheology.Methods:126 patients with cerebral infarction were randomly divided into control group(n=63)and observation group(n=63)by ball-touching method.Both groups received conventional treatment for cerebral infarction,the control group was given atorstatin calcium tablets for treatment,and the observation group treated with salvia miltiorrhiza polyphenolic acid injection on the basis of the treatment of the control group.The efficacy,hemorheology index,blood lipid index,NIHSS score,ADL score and adverse reactions were compared between the two groups.Results:After treatment,the levels of TG,HDL-C and TC in the observation group were lower than those in the control group,and the HDL-C level was higher than that in the control group,difference statistically significant(all P<0.05).The plasma specific viscosity,whole blood high shear viscosity,whole blood low shear viscosity,fibrinogen and hematocrit of the observation group were lower than those in the control group,difference statistically significant(all P<0.05).The NIHSS score of the observation group was lower than that in the control group and ADL score higher than that in the control group,difference statistically significant(all P<0.05).The total effective rate of 96.83% in the observation group was significantly higher than 84.13% in the control group,difference statistically significant(all P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Salvia miltiorrhiza acid injection combined with atorvastatin calcium tablet has good efficacy in the treatment of cerebral infarction,which can effectively improve blood lipid and hemodynamic indexes,improve the neurological function and quality of life of patients,better safety.

参考文献/References:

[1] Naess H,Kurtz M,Thomassen L,et al.Serial NIHSS scores in patients with acute cerebral infarction[J].Acta Neurol Scand,2016,133(6):415-420.
[2] 王 娟,郭 岩.瑞舒伐他汀和阿托伐他汀治疗急性脑梗死疗效及对患者神经功能影响比较研究[J].陕西医学杂志,2018,47(10):1331-1333.
[3] Yamamoto N,Nie M,Sasahara A,et al.Surgery for bilateral atrial thromboses detected in a cancer patient with cerebral infarction[J].Journal Mol Spectr,2015,44(4):221-223.
[4] Huang SH,Jiang JS,Xu ZM,et al.The efficacy and safety of thrombolytic agents for patients with cerebral infarction:A protocol for systematic review and network meta-analysis[J].Medicine,2018,97(52):e137-e139.
[5] 周志梅,买 雷,李艳红.消栓肠溶胶囊治疗脑梗死疗效及对患者NIHSS评分的影响[J].陕西中医,2019,40(6):696-699.
[6] 李明初,廖长琦,杨晓平.血塞通注射液联合阿托伐他汀钙治疗糖尿病合并脑梗死疗效及对患者神经功能的影响[J].中国现代医学杂志,2015,25(31):49-52.
[7] 杨彩艳,邹 堃,李宏辉,等.丹参多酚酸盐对阿托伐他汀钙在心肌缺血大鼠体内的药动学影响[J].中国药物应用与监测,2016,13(2):85-88.
[8] 蔡 伦,熊左隽,李 俊,等.甲基强的松龙冲击疗法治疗放射性脑水肿的疗效[J].中国临床神经外科杂志,2020,25(7):443-446.
[9] Mansfield MW,Catto AJ,Carter AM,et al.Fibrinolytic measurements in type 2 diabetic patients with acute cerebral infarction[J].Diab Med,2015,15(11):953-957.
[10] Du L,Ma J,Zhang X.Higher serum uric acid may contribute to cerebral infarction in patients with type 2 diabetes mellitus:A meta-analysis[J].Journal Mol Neur Mn,2016,61(1):1-7.
[11] Toshiaki T,Goda R,Naoki B,et al.A case of cerebral infarction in a patient with TAFRO syndrome[J].Journal Neurol Sci,2019,400(15):21-22.
[12] 尤晓涵,杨 淼,明霞光,等.盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J].陕西中医,2020,41(6):743-745,757.
[13] 王 珲,王 琴,戚 妹,等.丹参多酚酸盐对脑梗塞患者脑血流动力学的影响[J].海南医学,2015,25(6):794-796.
[14] 王丙聚,韩晓芳,郭爱红.阿托伐他汀钙联合血塞通注射液对糖尿病合并脑梗死患者血液流变指标和神经功能的影响[J].陕西医学杂志,2017,46(4):533-534.
[15] 王 娟,郭 岩.瑞舒伐他汀和阿托伐他汀治疗急性脑梗死疗效及对患者神经功能影响比较研究[J].陕西医学杂志,2018,47(10):1331-1333.
[16] Wang K,Zhang D,Wu J,et al.A comparative study of Danhong injection and salvia miltiorrhiza injection in the treatment of cerebral infarction:A systematic review and meta-analysis[J].Medicine,2017,96(22):e707-e709.
[17] 李子杰,马妮娜,柴小奇,等.阿司匹林联合氟桂利嗪对脑梗死患者血液流变学及神经功能的影响分析[J].陕西医学杂志,2020,49(7):878-880.
[18] 李 薇.丹红注射液在糖尿病合并脑梗死患者中的疗效研究[J].陕西中医,2018,39(7):894-896.
[19] Li M,Huang Y,Lin H,et al.Association of uric acid with stenosis of intracranial and extracranial arteries in elderly patients with cerebral infarction[J].Neurol Sci,2019,40(5):957-961.
[20] 钱承嗣,蒋 峻.注射用丹参多酚酸联合曲美他嗪治疗老年冠心病心绞痛患者疗效及对炎性因子、血管内皮损伤和血脂的影响[J].中国老年学杂志,2021,41(21): 4614-4617.
[21] 李剑萍.注射用丹参多酚酸治疗缺血性脑卒中对患者同型半胱氨酸、D-二聚体、高敏C反应蛋白水平与血液流变指标影响[J].中外医学研究,2021,19(29):25-28.
[22] 贾壮壮,袁 庆,陈红阳,等.丹参多酚酸配伍三七总皂苷通过调节PI3K/AKT信号通路对大鼠脑缺血/再灌注损伤神经元凋亡的影响[J].中国药理学通报,2020,36(9):1214-1220.
[23] 李小兵,王 旭,吕 瑛,等.丹参多酚酸对心房颤动大鼠心肌组织中VCAM-1和ICAM-1水平及ERK1/2-NF-κB信号通路的影响[J].吉林大学学报:医学版,2020,46(5):1004-1010.
[24] Cogswell RJ,Norby FL,Gottesman RF,et al.High prevalence of sub-clinical cerebral infarctions in patients with heart failure with preserved ejection fraction[J].Eur Journal Heart Fail,2017,19(10):1303-1309.
[25] 谭文刚.注射用丹参多酚酸联合尤瑞克林治疗急性心源性脑梗死的单中心前瞻性研究[J].药物评价研究,2019,42(2):273-277.

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备注/Memo

备注/Memo:
基金项目:新疆维吾尔自治区自然科学基金资助项目(2018D01A53)
更新日期/Last Update: 2022-03-09