[1]李 君.壮骨关节胶囊治疗膝骨关节炎疗效及安全性Meta分析[J].陕西中医,2022,(3):394-397.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.030]
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壮骨关节胶囊治疗膝骨关节炎疗效及安全性Meta分析
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年3期
页码:
394-397
栏目:
Meta分析
出版日期:
2022-03-05

文章信息/Info

作者:
李 君
(广东省中医院,广东 广州 510120)
关键词:
膝骨关节炎 壮骨关节胶囊 WOMAC评分 VAS评分 不良反应发生风险
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7369.2022.03.030
文献标志码:
A
摘要:
目的:系统评价壮骨关节胶囊治疗膝骨关节炎的临床疗效及安全性。方法:通过检索中国知网、万方数据、中国生物医学文献库、PubMed、Embase和Cochrane Library数据库,查找壮骨关节胶囊、壮骨关节胶囊联合其他西药、常规西药治疗膝骨关节炎的临床研究。应用RevMan 5.3软件进行Meta分析。结果:本研究共纳入7项临床研究,共538例患者。Meta分析结果表明,与对照组比较,试验组可提高治疗有效率[OR=4.63,95%CI(2.83,7.56),P<0.01]; 试验组WOMAC评分低于对照组[WMD=-13.14,95%CI(-22.07,-4.22),P<0.05]; 试验组VAS评分低于对照组[WMD=-15.49,95%CI(-18.84,-12.15),P<0.01]。试验组与对照组不良反应发生率比较,差异无统计学意义[OR=0.73,95%CI(0.30,1.78),P>0.05]。结论:壮骨关节胶囊治疗膝骨关节炎可降低患者VAS评分、WOMAC评分,提高有效率,临床疗效较好,但需关注其不良反应的发生风险。

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更新日期/Last Update: 2022-03-09