[1]谭 军,易晓利,任 迪,等.滋膵通脉饮治疗糖尿病心肌病疗效研究[J].陕西中医,2022,(6):715-719.[doi:DOI:10.3969/j.issn.1000-7369.2022.06.009]
　TAN Jun,YI Xiaoli,REN Di,et al.Clinical study on treatment of diabetic cardiomyopathy with Zicui Tongmai recipe[J].,2022,(6):715-719.[doi:DOI:10.3969/j.issn.1000-7369.2022.06.009]
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滋膵通脉饮治疗糖尿病心肌病疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年6期
页码:
715-719
栏目:
临床研究
出版日期:
2022-06-05

文章信息/Info

Title:
Clinical study on treatment of diabetic cardiomyopathy with Zicui Tongmai recipe
作者:
谭 军1; 易晓利2; 任 迪2; 袁春云1; 吴刚强1; 刘佳琴1; 毛 叶1; 陈 阳1; 卜献春1
(1.湖南省中医药研究院附属医院,湖南 长沙 410006; 2.长沙卫生职业学院,湖南 长沙 410100)
Author(s):
TAN Jun; YI Xiaoli; REN Di; YUAN Chunyun; WU Gangqiang; LIU Jiaqin; MAO Ye; CHEN Yang; BU Xianchun
(Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine,Changsha 410006,China)
关键词:
糖尿病心肌病;  滋膵通脉饮;  氧化应激;  炎症反应;  心功能
Keywords:
Diabetic cardiomyopathy;  Zicui Tongmai recipe;  Oxidative stress;  Inflammatory reaction;  Cardiac function
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7369.2022.06.009
文献标志码:
A
摘要:
目的:观察滋膵通脉饮治疗糖尿病心肌病(DCM)的临床疗效及作用机制。方法:将68例患者按随机数字表法分为观察组和对照组。两组均采取控制血糖、血压、血脂及抗心衰等综合治疗措施。对照组在西医综合治疗基础上口服天芪降糖胶囊。观察组在西医综合治疗基础上口服滋膵通脉饮,两组疗程均为4周。治疗前后观察两组患者血糖、血脂、胰岛素及胰岛素抵抗指数、炎症因子、氧化应激指标及心功能。结果:治疗后,观察组总有效率为80.00%高于对照组的50.00%,差异有统计学意义(P<0.05)。治疗后,观察组FBG、2 hPG、HbA1c、FINS、HOMA-IR水平低于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组hs-CRP、IL-6、TNF-α低于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组MDA水平低于对照组,SOD水平高于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组NT-proBNP水平低于对照组,E/A、LVEF水平高于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组NHYA心功能分级改善优于对照组,差异有统计学意义(P<0.05)。结论:滋膵通脉饮可提高DCM临床疗效,其机制可能与改善患者糖脂代谢及胰岛素抵抗、减轻氧化应激损伤和抑制炎症反应有关。
Abstract:
Objective:To study clinical effect and related mechanism on treatment of diabetic cardiomyopathy with Zicui Tongmai recipe.Methods:68 patients were divided into observation group and control group by random number table method.Both groups were given comprehensive treatment measures to control blood glucose,blood pressure,blood lipids and anti-heart failure.The control group combined with Tianqi Jiangtang capsule.The observation group combined with Zicui Tongmai recipe.The treatment course was 4 weeks in both groups.Before and after treatment,the levels of blood glucose,glycosylated hemoglobin,blood lipid,insulin and insulin resistance index,inflammatory factors,oxidative stress index and cardiac function were observed between two groups.Results:After treatment,the total effective rate of the observation group was 80.00% higher than 50.00% of the control group,difference statistically significant(P<0.05).After treatment,the levels of FBG,2 hPG,HbA1c,FINS and HOMA-IR in the observation group were lower than those in the control group,differences statistically significant(all P<0.05).After treatment,the levels of TG,TC and LDL-C in the observation group were lower than those in the control group,HDL-C level was higher than that in the control group,differences statistically significant(all P<0.05).After treatment,the levels of hs-CRP,IL-6 and TNF-α in the observation group were lower than those in the control group,differences statistically significant(all P<0.05).After treatment,the level of MDA in the observation group was lower and the level of SOD was higher than those in the control group,differences statistically significant(all P<0.05).After treatment,the level of NT-proBNP in the observation group was lower than that in the control group,and the levels of E/A and LVEF were higher than those in the control group,statistical significance(all P<0.05).After treatment,NHYA cardiac function grading improvement in the observation group was better than that in the control group,difference statistically significant(P<0.05).Conclusion:Zicui Tongmai recipe can improve clinical efficacy of DCM patients,the mechanism of which may be related to improving glucose and lipid metabolism,insulin resistance,alleviating oxidative stress injury and inhibiting inflammatory reaction.

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备注/Memo

备注/Memo:
基金项目:湖南省教育厅科研项目(20C1414); 湖南省中医药管理局青年基金资助项目(2021183); 湖南省中医药管理局重点项目(201607)
更新日期/Last Update: 2022-06-09