[1]彭 艳,肖 飞.真武汤加减联合盐酸纳美芬对老年脓毒性休克患者血流动力学及免疫功能的影响[J].陕西中医,2022,(7):897-901.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.020]
　PENG Yan,XIAO Fei.Effect of modified Zhenwu decoction combined with nalmefene hydrochloride on hemodynamics and immune function in elderly patients with septic shock[J].,2022,(7):897-901.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.020]
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真武汤加减联合盐酸纳美芬对老年脓毒性休克患者血流动力学及免疫功能的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年7期
页码:
897-901
栏目:
临床研究
出版日期:
2022-07-05

文章信息/Info

Title:
Effect of modified Zhenwu decoction combined with nalmefene hydrochloride on hemodynamics and immune function in elderly patients with septic shock
作者:
彭 艳1; 肖 飞2
(1.解放军南部战区总医院,广东 广州 510010; 2.南方医科大学南方医院,广东 广州 510500)
Author(s):
PENG Yan; XIAO Fei
(General Surgeon of the Southern Theater of the Chinese People's Liberation Army,Guangzhou 510010,China)
关键词:
老年脓毒性休克;  真武汤加减;  盐酸纳美芬;  血流动力学;  免疫功能;  炎症因子
Keywords:
Septic shock in the elderly;  Modified Zhenwu decoction;  Nalmefene hydrochloride;  Hemodynamics;  Immune function;  Inflammatory factors
分类号:
R 631.4
DOI:
DOI:10.3969/j.issn.1000-7369.2022.07.020
文献标志码:
A
摘要:
目的:探讨真武汤加减联合盐酸纳美芬对老年脓毒性休克患者血流动力学及免疫功能的影响。方法:选取82例老年脓毒性休克患者为研究对象,采用前瞻性随机研究,按照随机数字表法分为对照组和研究组,每组41例,对照组给予盐酸纳美芬治疗,研究组在对照组基础上给予真武汤加减。比较两组治疗前后中医证候积分、血流动力学指标、炎症因子、免疫功能及临床疗效。结果:治疗后,研究组总有效率高于对照组(P<0.05); 研究组各项中医证候评分低于对照组(均P<0.05); 研究组心率(HR)低于对照组,平均动脉压(MAP)、心输出量(CO)、每搏输出量(SV)、射血前期时间(PEP)高于对照组(均P<0.05); 研究组前降钙素(PCT)、C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α水平低于对照组(均P<0.05); 研究组CD3+、CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组(均P<0.05)。结论:真武汤加减联合盐酸纳美芬可有效降低老年脓毒性休克患者中医证候积分,调节血流动力学指标,减轻炎症反应,调节免疫功能,提高疗效。
Abstract:
Objective:To investigate the effects of modified Zhenwu decoction combined with nalmefene hydrochloride on hemodynamics and immune function in elderly patients with septic shock.Methods:82 elderly patients with septic shock were selected as the research objects.A prospective randomized study was adopted.According to the random number table method,they were divided into control group and study group,with 41 cases in each group.The control group was given nalmefene hydrochloride treatment,and the research group was given modified Zhenwu decoction on the basis of the control group.The scores of TCM syndromes,hemodynamic indicators,inflammatory factors,immune function,clinical efficacy were compared between the two groups before and after treatment.Results:After treatment,the total effective rate of the study group was higher than that of the control group(P<0.05).The scores of TCM syndromes in the study group were lower than those in the control group(all P<0.05).The heart rate(HR)of the study group was lower than that of the control group,and the mean arterial pressure(MAP),cardiac output(CO),stroke output(SV)and pre-ejection time(PEP)were higher than those of the control group(all P<0.05).The levels of precalcitonin(PCT),C-reactive protein(CRP),interleukin(IL-6)and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group(all P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in the study group were higher than those in the control group,while the level of CD8+ was lower than those in the control group(all P<0.05).Conclusion:Modified Zhenwu decoction combined with nalmefene hydrochloride can effectively reduce TCM syndrome score,regulate hemodynamic indexes,reduce inflammatory response,regulate immune function and improve curative effect in elderly patients with septic shock.

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备注/Memo

备注/Memo:
基金项目:广东省医学科学技术研究基金资助项目(A2017230,B2018084)
更新日期/Last Update: 2022-07-07