[1]杨 虎,符兆英,张正祥,等.神经内分泌和穴位刺激调节免疫及炎症机制研究进展[J].陕西中医,2022,(7):982-封3.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.042]
 YANG Hu,FU Zhaoying,ZHANG Zhengxiang,et al.Research progress on regulation of neuroendocrine and acupoint stimulation on immunity and inflammation[J].,2022,(7):982-封3.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.042]
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神经内分泌和穴位刺激调节免疫及炎症机制研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年7期
页码:
982-封3
栏目:
综 述
出版日期:
2022-07-05

文章信息/Info

Title:
Research progress on regulation of neuroendocrine and acupoint stimulation on immunity and inflammation
作者:
杨 虎符兆英张正祥董 闪薛睿阳马千娇
(延安大学医学院,陕西 延安 716000)
Author(s):
YANG HuFU ZhaoyingZHANG ZhengxiangDONG ShanXUE RuiyangMA Qianjiao
(College of Medicine,Yan'an University,Yan'an 716000,China)
关键词:
神经系统 内分泌系统 免疫系统 炎症反应 穴位 电针
Keywords:
Nervous system Endocrine system Immune system Inflammation response Acupuncture points Electric acupuncture
分类号:
R 392
DOI:
DOI:10.3969/j.issn.1000-7369.2022.07.042
文献标志码:
A
摘要:
神经系统、内分泌系统与免疫系统之间存在错综复杂的关系。神经内分泌信号对免疫细胞活性和免疫应答起重要的调节作用。促肾上腺皮质激素、内啡肽生长激素、催乳素对免疫细胞活性和免疫应答起刺激性或增强性调节作用,而生长抑素起抑制性调节作用。躯体感觉神经可将刺激信号传导到脑干,然后激活传出迷走神经,抑制炎症反应。肠道神经元通过反射性调节肠道巨噬细胞功能调节炎症反应。血脑屏障通过调节免疫细胞通透性调节自身免疫性疾病的进展。通过电针穴位刺激连接大脑与肾上腺的迷走神经可以减轻机体炎症。
Abstract:
There is an intricate relationship between nervous system,endocrine system and immune system.Neuroendocrine signals play an important role in the regulation of immune cell activity and immune response.Adrenocorticotropic hormone,endorphin growth hormone,and prolactin mainly play a stimulatory or enhancing role in regulating immune cell activity and immune response,while somatostatin mainly plays an inhibitory role.Somatosensory nerves send stimulatory signals to the brain stem,which then activate the efferent vagus nerve,which exerts inhibitory regulation of inflammation.Intestinal neurons modulate inflammatory responses by reflexively modulating the function of intestinal macrophages.The blood brain barrier regulates the onset and progression of autoimmune diseases by controlling the permeability of immune cells.Stimulating the vagus nerve,which connects the brain to the adrenal glands,could reduce inflammation.

参考文献/References:

[1] Koch CA,Antonelli A.Immunoendocrinology:When(neuro)endocrinology and immunology meet[J].Rev Endocr Metab Disord,2018,19(4):277-282.
[2] Chavan SS,Tracey KJ.Essential neuroscience in immunology[J].J Immunol,2017,198(9):3389-3397.
[3] Wang K,Du H,Chen Z,et al.ACTH4-10 protects the ADR-injured podocytes by stimulating B lymphocytes to secrete interleukin-10[J].Int Immunopharmacol,2020,87:106769.
[4] Obara RD,Kato Y,Asaoka Y,et al.Suspected spontaneous hyperadrenocorticism in a young experimental beagle dog[J].J Toxicol Pathol,2021,34(3):261-267.
[5] Stefano GB,Scharrer B,Smith EM,et al.Opioid and opiate immunoregulatory processes[J].Crit Rev Immunol,2017,37(2):213-248.
[6] Shulgach JA,Beam DW,Nanivadekar AC,et al.Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes[J].Sci Rep,2021,11(1):12925.
[7] Meazza C,Pagani S,Travaglino P,et al.Effect of growth hormone(GH)on the immune system[J].Pediatr Endocrinol Rev,2004,1(s3):490-495.
[8] Hattori N.Expression,regulation and biological actions of growth hormone(GH)and ghrelin in the immune system[J].Growth Horm IGF Res,2009,19(3):187-197.
[9] Matera L,Mori M,Galetto A.Effect of prolactin on the antigen presenting function of monocyte-derived dendritic cells[J].Lupus,2001,10(10):728-734.
[10] Wei M,Haney MG,Rivas DR,et al.Protein tyrosine phosphatase 4A3(PTP4A3/PRL-3)drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo[J].Oncogenesis,2020,9(1):6.
[11] Smaniotto S,Martins-Neto AA,Dardenne M,et al.Growth hormone is a modulator of lymphocyte migration[J].Neuroimmunomodulation,2011,18(5):309-313.
[12] Matera L,Beltramo E,Martinuzzi E,et al.Effect of prolactin on carcinoembryonic antigen-specific cytotoxic T lymphocyte response induced by dendritic cells[J].Clin Exp Immunol,2004,137(2):320-328.
[13] Palmerin N,Aalam F,Nabiee R,et al.Suppression of DC-SIGN and GH reveals complex,subset-specific mechanisms for KSHV entry in primary B lymphocytes[J].Viruses,2021,13(8):1512.
[14] Pech-Pool S,Berumen LC,Martinez-Moreno CG,et al.Thyrotropin-releasing hormone(TRH)and somatostatin(SST),but not growth hormone-releasing hormone(GHRH)nor ghrelin(GHRL),regulate expression and release of immune growth hormone(GH)from chicken bursal b-lymphocyte cultures[J].Int J Mol Sci,2020,21(4):1436.
[15] Siejka A,Lawnicka H,Komorowski J,et al.Effect of growth hormone-releasing hormone(GHRH)and GHRH antagonist(MZ-4-71)on interferon-gamma secretion from human peripheral blood mononuclear cells in vitro[J].Neuropeptides,2004,38(1):35-39.
[16] Klein JR,Wang HC.Characterization of a novel set of resident intrathyroidal bone marrow-derived hematopoietic cells:Potential for immune-endocrine interactions in thyroid homeostasis[J].J Exp Biol,2004,207(1):55-65.
[17] Hosono T,Bando M,Mizushina Y,et al.Inhibitory effects of somatostatin analogue in bleomycin-induced pulmonary fibrosis[J].Exp Lung Res,2021,47(6):280-288.
[18] Petrovic-Djergovic DM,Rakin AK,Kustrimovic NZ,et al.Somatostatin modulates T cells development in adult rat thymus[J].Regul Pept,2007,142(3):101-110.
[19] Kohm AP,Sanders VM.Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo[J].J Immunol,1999,162:5299-5308.
[20] Kruszewska B,Felten SY,Moynihan JA.Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice[J].J Immunol,1995,155:4613-4620.
[21] Kouassi E,Li YS,Boukhris W,et al.Opposite effects of the catecholamines dopamine and norepinephrine on murine polyclonal B-cell activation[J].Immunopharmacology,1988,16:125-137.
[22] Sanders VM,Munson AE.Kinetics of the enhancing effect produced by norepinephrine and terbutaline on the murine primary antibody response in vitro[J].J Pharmacol Exp Ther,1984,231:527-531.
[23] Sanders VM,Munson AE.Beta adrenoceptor mediation of the enhancing effect of norepinephrine on the murine primary antibody response in vitro[J].J Pharmacol Exp Ther,1984,230:183-192.
[24] Sanders VM,Kasprowicz DJ,Swanson-Mungerson MA,et al.Adaptive immunity in mice lacking the β2-adrenergic receptor[J].Brain Behav Immun,2003,17:55-67.
[25] Mina-Osorio P,Rosas-Ballina M,Valdes-Ferrer SI,et al.Neural signaling in the spleen controls B-cell responses to blood-borne antigen[J].Mol Med,2012,18:618-627.
[26] Torres-Rosas R,Yehia G,Pena G,et al.Dopamine mediates vagal modulation of the immune system by electroacupuncture[J].Nat Med,2014,20:291-295.
[27] Villegas-Bastida A,Torres-Rosas R,Arriaga-Pizano LA,et al.electrical stimulation at the ST36 acupoint protects against sepsis lethality and reduces serum TNF levels through vagus nerve-and catecholamine-dependent mechanisms[J].Evid Based Complement Alternat Med,2014,2014:451674.
[28] Song Q,Hu S,Wang H,et al.Electroacupuncturing at Zusanli point(ST36)attenuates pro-inflammatory cytokine release and organ dysfunction by activating cholinergic anti-inflammatory pathway in rat with endotoxin challenge[J].Afr J Tradit Complement Altern Med,2014,11:469-474.
[29] Lim HD,Kim MH,Lee CY,et al.Anti-inflammatory effects of acupuncture stimulation via the vagus nerve[J].PLoS One,2016,11:e151882.
[30] Erthal V,Nohama P,Werner MFDP,et al.The anti-inflammatory effects of laser acupuncture at ST36(Zusanli)acupoint in the model of acute inflammation induced by carrageenan in the paw of mice[J].Lasers Med Sci,2014,36:30-33.
[31] Matteoli G,Gomez-Pinilla PJ,Nemethova A,et al.A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen[J].Gut,2014,63:938-948.
[32] Muller PA,Koscso B,Rajani GM,et al.Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility[J].Cell,2014,158:300-313.
[33] Arima Y,Harada M,Kamimura D,et al.Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier[J].Cell,2012,148:447-457.
[34] Liu S,Wang ZF,Su YS,et al.Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture[J].Neuron,2020,108(3):436-450.
[35] Liu S,Wang Z,Su Y,et al.A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis[J].Nature,2021,598(7882):641-645.
[36] Ulloa L.Electroacupuncture activates neurons to switch off inflammation[J].Nature,2021,598(7882):573-574.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81760732); 陕西省重点研发计划项目(2022SF-393)
更新日期/Last Update: 2022-07-07