[1]张 茹,李 萍,赵艳茹,等.针刺联合乌灵胶囊与重复经颅磁刺激技术治疗卒中后抑郁疗效及对患者神经递质的影响[J].陕西中医,2022,(8):1114-1117.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.031]
　ZHANG Ru,LI Ping,ZHAO Yanru,et al.Clinical curative effect of acupuncture combined with Wuling capsule and rTMS on post-stroke depression and its influences on neurotransmitters[J].,2022,(8):1114-1117.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.031]
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针刺联合乌灵胶囊与重复经颅磁刺激技术治疗卒中后抑郁疗效及对患者神经递质的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年8期
页码:
1114-1117
栏目:
针灸经络
出版日期:
2022-08-05

文章信息/Info

Title:
Clinical curative effect of acupuncture combined with Wuling capsule and rTMS on post-stroke depression and its influences on neurotransmitters
作者:
张 茹; 李 萍; 赵艳茹; 杨 柳
(秦皇岛市第一医院,河北 秦皇岛 066099)
Author(s):
ZHANG Ru; LI Ping; ZHAO Yanru; YANG Liu
(Qinhuangdao First Hospital,Qinhuangdao 066099,China)
关键词:
卒中后抑郁;  乌灵胶囊;  重复经颅磁刺激技术;  神经递质;  神经生长因子
Keywords:
Post-stroke depression;  Wuling capsule;  Repetitive transcranial magnetic stimulation;  Neurotransmitter;  Nerve growth factor
分类号:
R 749.41
DOI:
DOI:10.3969/j.issn.1000-7369.2022.08.031
文献标志码:
A
摘要:
目的:探讨针刺联合乌灵胶囊与重复经颅磁刺激技术(rTMS)治疗卒中后抑郁(PSD)的临床疗效及对患者神经递质水平的影响。方法:将96例的PSD患者随机分为观察组和对照组,各48例。对照组予以rTMS治疗,观察组在其基础上予以乌灵胶囊口服治疗。治疗8周后,比较两组疗效; 比较两组治疗前后抑郁情绪及神经功能损伤情况变化; 比较两组治疗前后单胺类神经递质以及神经细胞因子水平变化; 比较两组治疗期间用药安全性。结果:观察组患者治疗后总体疗效优于对照组(P<0.05); 两组治疗后汉密尔顿抑郁量表、美国国立卫生研究院卒中量表评分水平较治疗前均有降低,且观察组低于对照组(P<0.05); 两组治疗后脑源性神经营养因子、神经生长因子、5-羟色胺、去甲肾上腺素及多巴胺水平较治疗前均有提升,且观察组高于对照组(P<0.05); 治疗期间两组均未发生严重不良反应(P>0.05)。结论:针刺联合乌灵胶囊及rTMS治疗PSD的临床效果显著,可提升患者神经营养因子及相关神经递质水平,有效缓解其负面情绪,对其神经损伤也有一定的修复作用,且安全性较高。
Abstract:
Objective:To explore the clinical curative effect of acupuncture combined with Wuling capsule and repetitive transcranial magnetic stimulation(rTMS)on post-stroke depression(PSD)and its influences on neurotransmitters.Methods:A total of 96 patients with PSD were randomly divided into observation group(n=48)and control group(n=48).The control group was treated with rTMS,while observation group was additionally treated with Wuling capsules.After 8 weeks of treatment,curative effect,changes of depression,nerve function damage and levels of monoamine neurotransmitters and nerve cytokines before and after treatment,and medication safety during treatment were compared between the two groups.Results:After treatment,overall curative effect of observation group was better than that of control group(P<0.05).After treatment,scores of hamilton depression scale and national institutes of health stroke scale in both groups were decreased,which were lower in observation group than control group(P<0.05).After treatment,levels of brain-derived neurotrophic factor(BDNF),nerve growth factor,5-hydroxytryptamine(5-HT),norepinephrine and dopamine in both groups were increased,which were higher in observation group than control group(P<0.05).There were no serious adverse reactions in either group during treatment(P>0.05).Conclusion:Clinical curative effect of acupuncture combined with Wuling capsule and rTMS is significant on PSD,which can increase levels of neurotrophic factors and related neurotransmitters,effectively relieve negative emotions and play certain repair effects on nerve damage,with higher safety.

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备注/Memo

备注/Memo:
基金项目:河北省秦皇岛市重点研发计划科技支撑项目(202004A094)
更新日期/Last Update: 2022-08-10