[1]寇林利,赵明君,魏明明,等.苓桂术甘汤对慢性心力衰竭大鼠心肌功能及心室重构的影响[J].陕西中医,2022,(9):1170-1174.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.004]
　KOU Linli,ZHAO Mingjun,WEI Mingming,et al.Effect on improvement of myocardial function and ventricular remodeling in rats with chronic heart failure by Linggui Zhugan decoction[J].,2022,(9):1170-1174.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.004]
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苓桂术甘汤对慢性心力衰竭大鼠心肌功能及心室重构的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年9期
页码:
1170-1174
栏目:
基础研究
出版日期:
2022-09-05

文章信息/Info

Title:
Effect on improvement of myocardial function and ventricular remodeling in rats with chronic heart failure by Linggui Zhugan decoction
作者:
寇林利1; 赵明君2; 魏明明1; 李莹超2
(1.陕西中医药大学,陕西 咸阳 712046; 2.陕西中医药大学附属医院,陕西 咸阳 712021)
Author(s):
KOU Linli; ZHAO Mingjun; WEI Mingming; LI Yingchao
(Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China)
关键词:
心力衰竭;  苓桂术甘汤;  心室重构;  二维斑点追踪技术;  心肌应变
Keywords:
Heart failure;  Linggui Zhugan decoction;  Ventricular remodeling;  Two dimensional speckle tracking echocardiography;  Myocardial strain
分类号:
R 541.6
DOI:
DOI:10.3969/j.issn.1000-7369.2022.09.004
文献标志码:
A
摘要:
目的:基于二维斑点追踪技术(2D-STE)探讨苓桂术甘汤改善慢性心力衰竭大鼠心肌功能及心室重构机制。方法:选取44只SPF级SD大鼠,连续4周腹腔注射阿霉素,建立慢性心力衰竭大鼠模型。将造模成功的SD大鼠随机分为空白组、模型组、地高辛组、苓桂术甘汤组进行观察。结果:地高辛组、苓桂术甘汤组左室射血分数(LVEF)、左室短轴缩短率(FS)、左心室室间隔二维应变参数(绝对值)、二维斑点纵向应变绝对值(GLS)均升高,左室舒张末内径(LVIDd)、左室收缩末内径(LVIDs)降低,差异有统计学意义(均P<0.05)。地高辛组、苓桂术甘汤组血浆B型脑钠肽(BNP)、血管紧张素Ⅱ(Ang-Ⅱ)及内皮素1(ET-1)降低,差异有统计学意义(均P<0.05)。地高辛组ET-1、室间隔各节段纵向应变参数(绝对值)、GLS均较苓桂术甘汤组高,差异有统计学意义(均P<0.05)。GLS与BNP、Ang-Ⅱ及ET-1呈正相关性。结论:苓桂术甘汤可改善慢性心力衰竭大鼠心肌功能及心室重构,且与血清学指标相符。
Abstract:
Objective:To investigate efficacy of Linggui Zhugan decoction in mechanism of improving myocardial function and ventricular remodeling in chronic heart failure rats based on 2D-STE.Methods:44 SPF-grade SD rats were selected and injected intraperitoneally with adriamycin for 4 weeks to establish rat model of chronic heart failure.The successfully modeled SD rats were randomly divided into blank group,model group,digoxin group and Linggui Zhugan decoction group for observation.Results:The left ventricular ejection fraction(LVEF),fraction shortening(FS),left ventricular septal two-dimensional strain parameter(absolute value),and two-dimensional speckle longitudinal strain absolute value(GLS)were increased and the left ventricular end-diastolic internal diameter(LVIDd)and left ventricular end-systolic internal diameter(LVIDs)decreased in the the digoxin group and the Linggui Zhugan decoction group,difference statistically significant(all P<0.05).Plasma B brain natriuretic peptide(BNP),angiotensin Ⅱ(Ang-Ⅱ)and endothelin 1(ET-1)were reduced in the the digoxin group and the Linggui Zhugan decoction group,difference statistically significant(all P<0.05).ET-1,longitudinal strain parameters(absolute values)and GLS were higher in the digoxin group than those in the Linggui Zhugan decoction group,difference statistically significant(all P<0.05).GLS was positively correlated with BNP,Ang-Ⅱ and ET-1.Conclusion:Linggui Zhugan decoction can significantly improve myocardial function and ventricular remodeling in rats with chronic heart failure.The results are consistent with serological indexes.

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备注/Memo

备注/Memo:
基金项目:陕西省咸阳市科技局科研项目(2021ZDYF-SF-0034); 陕西中医药大学附属医院科研项目(2020QN007)
更新日期/Last Update: 2022-09-08