[1]韦茂英,赵琦瑶,高云逸,等.补阳还五汤联合西医治疗糖尿病脑病Meta分析[J].陕西中医,2022,(9):1310-1315.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.040]
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补阳还五汤联合西医治疗糖尿病脑病Meta分析
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年9期
页码:
1310-1315
栏目:
Meta分析
出版日期:
2022-09-05

文章信息/Info

作者:
韦茂英赵琦瑶高云逸潘欣渝方泽阳魏军平
(中国中医科学院广安门医院,北京 100053)
关键词:
糖尿病脑病 补阳还五汤 日常生活能力评分 神经功能缺损评分 血液流变学 炎症因子
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2022.09.040
文献标志码:
A
摘要:
目的:系统评价补阳还五汤联合西医治疗糖尿病脑病的疗效。方法:检索国内外中英文数据库,纳入补阳还五汤联合西医治疗糖尿病脑病随机对照试验。经两名研究人员独立筛选文献、提取数据和方法学质量评价后,运用Rev Man 5.3软件进行分析。结果:共纳入14篇文献,累计1487例患者。与对照组相比,补阳还五汤联合西医治疗可提高总有效率[RR=1.22,95%CI(1.17,1.28),P<0.01]和日常生活能力评分[MD=15.82,95%CI(6.94,24.70),P<0.01],并降低神经功能缺损评分[MD=-2.62,95%CI(-3.29,-1.94),P<0.01]、血清炎症因子[MD=-2.26,95%CI(-2.85,-1.66),P<0.01]、血液流变学指标[MD=-0.26,95%CI(-0.29,-0.23),P<0.01]及中医证候积分[MD=-7.32,95%CI(-7.96,-6.67),P<0.01]。结论:补阳还五汤联合西医治疗糖尿病脑病疗效较好,但受文献数量、质量限制,仍有待临床试验进一步证实。

参考文献/References:

[1] Wang Z,Huang Y,Cheng Y,et al.Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy[J].Oncotarget,2016,7(48):78455-78472.
[2] 叶仁群,林国彬,邓淑玲,等.补阳还五汤治疗糖尿病及其并发症的研究进展[J].山东中医药大学学报,2010,34(6):546-548.
[3] 曹翠华.对2型糖尿病合并脑梗死给予补阳还五汤治疗的效果分析[J].世界最新医学信息文摘,2019,19(49):176,189.
[4] 陈伟强.补阳还五汤联合阿司匹林治疗2型糖尿病合并脑梗死患者50例[J].环球中医药,2016,9(9):1108-1110.
[5] 张 勤.补阳还五汤加味治疗糖尿病性急性脑梗死80例[J].中医研究,2009,22(8):36-37.
[6] Higgins JP,Altman DG,Gotzsche PC,et al.The cochrane collaboration's tool for assessing risk of bias in randomised trials[J].BMJ,2011,343(3):592-598.
[7] Higgins JP,Thompson SG,Deeks JJ,et al.Measuring inconsistency in meta-analyses[J].BMJ,2003,327(7414):557-560.
[8] 杨良锋.补阳还五汤治疗2型糖尿病合并脑梗死51例观察[J].中医学报,2018,33(1):54-58.
[9] 赵明刚,马茂芝.中西医结合治疗2型糖尿病合并脑梗死临床研究[J].实用中医药杂志,2017,33(6):693-694.
[10] 郑桂芝,梁汝庆,孙 冰,等.补阳还五汤对不同危险因素脑梗死患者血清MMP-9含量的影响[J].中华中医药学刊,2016,34(1):198-200.
[11] 张 芳.补阳还五汤治疗2型糖尿病合并短暂性脑缺血发作80例临床观察[J].中医临床研究,2015,7(7):6-7.
[12] 陈玉芹,温会新,刘春梅.依达拉奉联合补阳还五汤治疗糖尿病性脑梗死的疗效观察[C].//第十一次中国中西医结合神经科学术会议论文集,2015:141-142.
[13] 王 勇,王定远,王培林.补阳还五汤加减治疗糖尿病并发脑梗死临床观察[J].中医药临床杂志,2013,25(11):996-997.
[14] 郑冬良.加味补阳还五汤为主治疗糖尿病合并缺血性脑血管病37例[J].浙江中医杂志,2012,47(4):260.
[15] 王少阳,李文明,刘莲英.补阳还五汤加味治疗糖尿病合并脑梗死随机对照临床研究[J].实用中医内科杂志,2012,26(11):39,41.
[16] 方懿珊,林小燕,陈邦士.补阳还五汤对糖尿病并发脑梗死的治疗作用[J].中西医结合心脑血管病杂志,2005,3(7):598-599.
[17] 吕冰峰,王 伟,陈 奎.丹奥联合加味补阳还五汤治疗糖尿病性急性脑梗死的疗效观察[J].中西医结合心脑血管病杂志,2004,2(5):307-308.
[18] 刘建平.补阳还五汤治疗糖尿病并发脑梗死疗效观察[J].现代中西医结合杂志,2003,12(16):1744-1745.
[19] Sun H,Saeedi P,Karuranga S,et al.IDF diabetes atlas:Global regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J].Diabetes Res Clin Pract,2021,183(1):1091-1099.
[20] Xue M,Xu W,Ou YN,et al.Diabetes mellitus and risks of cognitive impairment and dementia:A systematic review and meta-analysis of 144 prospective studies[J].Ageing Res Rev,2019,55(3):100-109.
[21] 孙大伟,冯丽莎,吴晓翠,等.基于Sirt1探讨糖尿病脑病“瘀毒阻络”中医病机及治法[J].中医学报,2019,34(8):1621-1624.
[22] Shen J,Huang K,Zhu Y,et al.Buyang Huanwu decoction promotes angiogenesis after cerebral ischemia by inhibiting the Nox4/ROS pathway[J].Evid Based Complement Alternat Med,2020,20(10):5264-5268.
[23] Zheng XW,Shan CS,Xu QQ,et al.Buyang Huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury[J].Front Neurosci,2018,12(1):91-100.
[24] 李虎虎,魏 冰,曾文赟,等.黄芪注射液抑制糖尿病大鼠海马神经元凋亡的机制研究[J].天津中医药,2017,34(12):836-840.
[25] Huang YC,Tsay HJ,Lu MK,et al.Astragalus membranaceus-polysaccharides ameliorates obesity,hepatic steatosis,neuroinflammation and cognition impairment without affecting amyloid deposition in metabolically stressed APPswe/PS1dE9 mice[J].Int Journal Mol Sci,2017,18(12):2746.

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备注/Memo

备注/Memo:
基金项目:北京市中医药科技发展资金资助项目(JCZX2020-09); 中国中医科学院中医药“一带一路”合作专项课题(GH201907)
更新日期/Last Update: 2022-09-08