[1]陈抒鹏,王思梦,唐娜娜,等.基于浊邪与铁死亡相关性探析动脉粥样硬化之病机[J].陕西中医,2022,(11):1589-1591,1595.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.023]
　CHEN Shupeng,WANG Simeng,TANG Nana,et al.Exploring the pathogenesis of atherosclerosis based on the correlation between turbid pathogens and ferroptosis[J].,2022,(11):1589-1591,1595.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.023]
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基于浊邪与铁死亡相关性探析动脉粥样硬化之病机
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年11期
页码:
1589-1591,1595
栏目:
学术探讨
出版日期:
2022-11-05

文章信息/Info

Title:
Exploring the pathogenesis of atherosclerosis based on the correlation between turbid pathogens and ferroptosis
作者:
陈抒鹏1; 王思梦1; 唐娜娜2; 刘中勇2
(1.江西中医药大学,江西 南昌 330004; 2.江西中医药大学附属医院,江西 南昌 330006)
Author(s):
CHEN Shupeng; WANG Simeng; TANG Nana; LIU Zhongyong
(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
关键词:
动脉粥样硬化;  浊;  铁死亡;  同病异治;  脂代谢
Keywords:
Atherosclerosis;  Turbidity;  Ferroptosis;  Different treatment of the same disease;  Lipid metabolism
分类号:
R 543
DOI:
DOI:10.3969/j.issn.1000-7369.2022.11.023
文献标志码:
A
摘要:
动脉粥样硬化(AS)作为一种血管退行性病变,是心血管疾病共同的病理基础。铁死亡是一种铁依赖性脂质活性氧积聚的细胞程序性死亡方式。越来越多的研究发现AS的发病机制与铁死亡相关。中医学认为“浊邪”是AS的主要病机,铁死亡与中医学“浊邪”存在一定相关性。本文从铁代谢、脂代谢、氨基酸代谢、三羧酸循环、芬顿反应及铁死亡的主要通路探究中医浊邪产生的机制,以细胞的铁死亡方式具化中医学“浊邪”,分析不同形式的“浊邪”,提出铁蓄积的“瘀浊”以活血化瘀法,脂代谢异常的“脂浊”以健脾化浊法,抗氧化系统异常的“浊邪”以补肾固精等治法抑制铁死亡抗AS,为中医药精准化防治AS提供新视角。
Abstract:
Atherosclerosis(AS)as a vascular degenerative lesion is the common pathological basis of cardiovascular diseases.Ferroptosis is a form of programmed cell death by iron-dependent accumulation of lipid reactive oxygen species.A growing number of studies have found that the pathogenesis of AS are related to ferroptosis.According to Chinese medicine,“turbidity” is the main pathogenesis of AS,and there is a correlation between ferroptosis and “turbidity” in Chinese medicine.In this paper,we investigated the mechanism of iron metabolism,lipid metabolism,amino acid metabolism,tricarboxylic acid cycle,Fenton reaction and the main pathways of ferroptosis in Chinese medicine.We propose the treatment of “stagnation” of iron accumulation by activating blood circulation and resolving stasis,“lipid” of abnormal lipid metabolism by strengthening the spleen and resolving turbidity,and “turbidity” of abnormal antioxidant system by tonifying the kidneys and consolidating essence to inhibit iron death against AS.This study provides a new perspective for the precise prevention and treatment of AS in Chinese medicine.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81660781); 全国名老中医专家传承工作室建设项目[国中药人教函(2022)7号]; 江西省中医药科技计划重点项目(2021Z013); 江西省中医药中青年骨干人才培养计划项目[赣中医药科教字(2021)4号]
更新日期/Last Update: 2022-11-09