[1]姚海珍,冯 亮,解 娟,等.补肺强心方治疗慢性血栓栓塞性肺动脉高压疗效研究[J].陕西中医,2022,(12):1713-1716.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.014]
　YAO Haizhen,FENG Liang,XIE Juan,et al.Clinical effect of Bufei Qiangxin recipe on chronic thromboembolic pulmonary hypertension[J].,2022,(12):1713-1716.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.014]
点击复制

补肺强心方治疗慢性血栓栓塞性肺动脉高压疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年12期
页码:
1713-1716
栏目:
临床研究
出版日期:
2022-12-20

文章信息/Info

Title:
Clinical effect of Bufei Qiangxin recipe on chronic thromboembolic pulmonary hypertension
作者:
姚海珍; 冯 亮; 解 娟; 张 明; 甄利波
(保定市第一中心医院,河北 保定 071000)
Author(s):
YAO Haizhen; FENG Liang; XIE Juan; ZHANG Ming; ZHEN Libo
(Baoding First Central Hospital,Baoding 071000,China)
关键词:
慢性血栓栓塞性肺动脉高压;  补肺强心方;  枸橼酸西地那非;  血管内皮生长因子;  内皮素;  心肺功能
Keywords:
Chronic thromboembolic pulmonary hypertension;  Bufei Qiangxin recipe;  Sildenafil citrate;  Vascular endothelial growth factor;  Endothelin;  Cardiopulmonary function
分类号:
R 563
DOI:
DOI:10.3969/j.issn.1000-7369.2022.12.014
文献标志码:
A
摘要:
目的:探讨补肺强心方治疗慢性血栓栓塞性肺动脉高压(CTEPH)临床疗效及对患者血管内皮功能的影响。方法:选取86例CTEPH患者,随机分成对照组和观察组。对照组采用枸橼酸西地那非等常规治疗,观察组联合补肺强心方治疗。观察两组临床症状积分、Borg 呼吸困难指数评分、6 min步行距离(6MWD)、超声心动图指标[肺动脉收缩压(PASP)、右室舒张末期内径(RVEDD)、右心室 Tei 指数]及血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)]的改善情况,并比较两组临床疗效和治疗安全性。结果:观察组治疗总有效率高于对照组(P<0.05)。观察组治疗后临床症状积分、Borg 呼吸困难指数、PASP、RVEDD、右心室 Tei 指数、ET-1、VEGF水平低于对照组(均P<0.05)。观察组治疗后6MWD、NO水平高于对照组(均P<0.05)。两组治疗期间均未出现明显不良反应。结论:补肺强心方能够调节CTEPH患者血管内皮功能,降低患者肺动脉压,改善右心室功能状态和运动耐力,疗效较好。
Abstract:
Objective:To explore the clinical effect of Bufei Qiangxin recipe on chronic thromboembolic pulmonary hypertension(CTEPH)and its influence on vascular endothelial function.Methods:86 patients with CTEPH were randomly divided into control group and observation group.The control group were treated with sildenafil citrate and other conventional treatments,and the observation group were treated with combined with Bufei Qiangxin recipe.The improvement of clinical symptom score,Borg dyspnea index score,6-minute walking distance(6MWD),echocardiographic indexes [pulmonary artery systolic pressure(PASP),right ventricular end diastolic diameter(RVEDD),right ventricular Tei index] and vascular endothelial function indexes [nitric oxide(NO),endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)were observed in the two groups.The clinical efficacy and safety of the two groups were compared.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).The scores of clinical symptoms,Borg dyspnea index,PASP,RVEDD,Tei index of right ventricle,ET-1 and VEGF in the observation group were lower than those in the control group(all P<0.05).The levels of 6MWD and NO in the observation group were higher than those in the control group(all P<0.05).There were no obvious adverse reactions in both groups during the treatment period.Conclusion:Bufei Qiangxin recipe can regulate the vascular endothelial function,reduce the pulmonary artery pressure,and improve the right ventricular function and exercise endurance in patients with CTEPH,which has better effect.

参考文献/References:

[1] Papamatheakis DG,Poch DS,Fernandes TM,et al.Chronic thromboembolic pulmonary hypertension:JACC focus seminar[J].Journal Am Coll Cardiol,2020,76(18):2155-2169.
[2] Klok FA,Couturaud F,Delcroix M,et al.Diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism[J].Respir Journal,2020,55(6):2000-2018.
[3] 龙愉良,管丽华,周达新.慢性血栓栓塞性肺动脉高压的诊疗进展[J].中国临床新医学,2020,13(9):863-868.
[4] 胡欣妍.桃红四物汤对急性肺栓塞发展为慢性血栓栓塞性肺动脉高压症的干预作用[J].中国中医药科技,2017,24(4):525-527.
[5] 宋国斌,张丽娟,周凤鱼.芪苈强心胶囊联合靶向药物治疗急性肺栓塞后所致慢性血栓栓塞性肺动脉高压疗效及对血管内皮功能及心肺功能的影响[J].现代中西医结合杂志,2019,28(28):3119-3123.
[6] 钟南山.临床诊疗指南:呼吸病学分册[M].北京:人民卫生出版社,2009:102-103.
[7] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:77-85,219.
[8] Fernandes T,Planquette B,Sanchez O,et al.From acute to chronic thromboembolic disease[J].Ann Am Thorac Soc,2016,13(3):s207-s214.
[9] 谢万木.慢性肺血栓栓塞症与慢性血栓栓塞性肺动脉高压[J].中国实用内科杂志,2021,41(6):508-511.
[10] 张瑞华,张静文,刘 玲,等.黄芪及其有效组分药理作用与临床应用现状[J].陕西中医,2021,42(8):1138-1141,1146.
[11] 谢 琦,程雪梅,胡芳弟,等.党参化学成分、药理作用及质量控制研究进展[J].上海中医药杂志,2020,54(8):94-104.
[12] 林雪竹,李蔚群,关永霞,等.葶苈子化学成分及药理作用研究进展[J].中国现代中药,2022,24(3):550-558.
[13] 张维君,韩东卫,李 冀.泽泻的化学成分及药理作用研究进展[J].中医药学报,2021,49(12):98-102.
[14] 张晓娟,张燕丽,左冬冬.川芎的化学成分和药理作用研究进展[J].中医药信息,2020,37(6):128-133.
[15] 单晓晓,洪帮振,刘 洁,等.丹参化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析[J].中国中药杂志,2021,46(21):5496-5511.
[16] 王怡丹,李一丹,吕秀章,等.超声评价慢性血栓栓塞性肺动脉高压患者肺动脉压力与右心室功能的关系[J].中华超声影像学杂志,2015,24(8):648-651.
[17] 郭迪晨,李一丹,杨媛华,等.超声心动图评估肺动脉内膜剥脱术疗效的临床研究[J].中国超声医学杂志,2018,34(1):17-20.
[18] 沈宗博,戴路明.血管内皮损伤标志物在肺血栓栓塞症中相关研究进展[J].中国基层医药,2018,25(16):2174-2176.
[19] 杨永超.一氧化氮信号通路在肺动脉高压发病机制中的作用[J].实用医学杂志,2015,31(1):155-157.
[20] 侯万举,曹 洁.生长因子在肺动脉高压发病机制中的研究进展[J].中华结核和呼吸杂志,2018,41(2):116-119.

备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研项目(2018432)
更新日期/Last Update: 2022-12-09