[1]何 俊,李 林,吴沣琳,等.活血化瘀补气方联合美托洛尔缓释片治疗急性心肌梗死恢复期疗效及对患者心功能、血清炎症因子的影响[J].陕西中医,2023,(1):60-63,79.[doi:DOI:10.3969/j.issn.1000-7369.2023.01.014]
　HE Jun,LI Lin,WU Fenglin,et al.Effect of Huoxue Huayu Buqi decoction combined with metoprolol sustained-release tablets on convalescent patients with acute myocardial infarction and its influence on cardiac function and serum inflammatory factors[J].,2023,(1):60-63,79.[doi:DOI:10.3969/j.issn.1000-7369.2023.01.014]
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活血化瘀补气方联合美托洛尔缓释片治疗急性心肌梗死恢复期疗效及对患者心功能、血清炎症因子的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年1期
页码:
60-63,79
栏目:
临床研究
出版日期:
2023-01-05

文章信息/Info

Title:
Effect of Huoxue Huayu Buqi decoction combined with metoprolol sustained-release tablets on convalescent patients with acute myocardial infarction and its influence on cardiac function and serum inflammatory factors
作者:
何 俊1; 李 林1; 吴沣琳1; 何丽娟1; 郭振邦1; 侯兴志2
(1.巴中市中心医院心血管中心,四川 巴中 636000; 2.彭水自治县人民医院心内科,重庆 彭水 409699)
Author(s):
HE Jun; LI Lin; WU Fenglin; HE Lijuan; GUO Zhenbang; HOU Xingzhi
(Cardiovascular Center,Bazhong Central Hospital,Bazhong 636000,China)
关键词:
心肌梗死;  活血化瘀补气方;  美托洛尔;  心功能;  炎症;  血液流变学;  γ干扰素;  C-反应蛋白;  内皮缩血管肽1
Keywords:
Myocardial infarction;  Huoxue Huayu Buqi decoction;  Metoprolol;  Cardiac function;  Inflammation;  Hemor heological;  Interferon γ;  High sensitivity C-reactive protein;  Endothelin 1
分类号:
R 542.22
DOI:
DOI:10.3969/j.issn.1000-7369.2023.01.014
文献标志码:
A
摘要:
目的:探究活血化瘀补气方联合美托洛尔缓释片治疗急性心肌梗死(AMI)恢复期患者的疗效及对患者心功能、血清炎症因子的影响。方法:选取102例急性心肌梗死恢复期患者为研究对象,按照随机化分组法分为西药组和中西组各51例,两组均常规控制血压、调脂、抗炎等对症治疗,西药组在其基础上给予美托洛尔缓释片治疗,中西组在西药组基础上加用活血化瘀补气方治疗,比较两组临床疗效、中医证候积分、心功能[左心室舒张末期内径(LVEDD)、左室收缩末径(LVSED)、左室射血分数(LVEF)]、血液流变学指标[全血低切黏度(LSV)、全血高切黏度(HSV)、血浆黏度(PSV)和红细胞比容(HCT)]、血清炎症因子水平变化情况[γ干扰素(IFN-γ)、C-反应蛋白(hs-CRP)、内皮缩血管肽1(ET-1)、心肌肌钙蛋白I(cTnI)]及药物不良反应。结果:中西组临床疗效为94.12%,显著高于西药组的80.39%,差异有统计学意义(P<0.05); 治疗后,两组心胸刺痛、胸闷、心悸乏力、气短神倦、面色紫暗等证候积分均显著降低(P<0.05),两组LVSED、LVEDD均显著降低(P<0.05),LVEF均显著升高(P<0.05),两组LBV、HBV、PV、HCT及血清IFN-γ、hs-CRP、ET-1、cTnI水平均显著降低(P<0.05),且治疗后上述指标中西组改善效果显著优于西药组(P<0.05); 治疗期间,西药组不良反应率为11.76%,中西组为7.84%,组间比较差异无统计学意义(P>0.05)。结论:活血化瘀补气方联合美托洛尔缓释片可显著提高AMI恢复期患者临床疗效,改善心功能和血清炎症。
Abstract:
Objective:To explore the effects of Huoxue Huayu Buqi decoction combined with metoprolol sustained-release tablets in the treatment of patients with acute myocardial infarction(AMI)in the convalescent period and its influence on cardiac function and serum inflammatory factors.Methods:102 patients with convalescent AMI were divided into western medicine group and Chinese and western medicine group according to random grouping method,with 51 cases in each group.Both groups received conventional symptomatic treatments such as blood pressure control,lipid regulation and anti-inflammation,and the western medicine group was given metoprolol sustained-release tablets on this basis,and the Chinese and western medicine group was additionally given Huoxue Huayu Buqi decoction on the basis of the western medicine group.The clinical efficacy,scores of TCM syndromes,cardiac function [Left ventricular end-diastolic diameter(LVEDD),Left ventricular end-systolic diameter(LVSED),Left ventricular ejection fraction(LVEF)],hemor heological indicators [whole blood low shear viscosity(LSV),whole blood high shear viscosity(HSV),plasma viscosity(PSV),hematocrit(HCT)],serum inflammatory factors [Interferon γ(IFN-γ),high sensitivity C-reactive protein(hs-CRP),Endothelin 1(ET-1),cardiac troponin I(cTnI)] and adverse drug reactions were compared between the two groups.Results:The clinical efficacy of 94.12% in the Chinese and western medicine group was significantly higher than 80.39% in the western medicine group(P<0.05).After treatment,the scores of syndromes such as cardiothoracic tingling,chest tightness,palpitations and fatigue,shortness of breath and tiredness and dark purple complexion were significantly reduced in both groups(P<0.05),and the LVSED and LVEDD in both groups were significantly decreased(P<0.05),while the LVEF was significantly increased(P<0.05),and the LBV,HBV,PV,HCT and levels of serum IFN-γ,hs-CRP,ET-1 and cTnI in two groups were significantly declined(P<0.05),and the improvement effects of the above indicators in the Chinese and western medicine group after treatment were significantly higher than those in the western medicine group(P<0.05).During treatment,the adverse reaction rate of the western medicine group was 11.76% and that in the Chinese and western medicine group was 7.84%(P>0.05).Conclusion:Huoxue Huayu Buqi decoction combined with metoprolol sustained-release tablets can significantly enhance the clinical efficacy and improve the cardiac function and serum inflammation of patients with convalescent AMI.

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备注/Memo

备注/Memo:
基金项目:重庆市科技卫生联合医学科研项目(2019MSXM105)
更新日期/Last Update: 2022-12-28