[1]范小虹,余德玲,祁 蕙.脑心通胶囊联合复方曲肽注射液治疗脑梗死恢复期临床研究[J].陕西中医,2023,(2):187-190.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.011]
　FAN Xiaohong,YU Deling,QI Hui.Effect of Naoxintong capsule combined with compound troxerutin and porcine cerebroside injection in the treatment of patients with cerebral infarction in convalescent stage[J].,2023,(2):187-190.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.011]
点击复制

脑心通胶囊联合复方曲肽注射液治疗脑梗死恢复期临床研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年2期
页码:
187-190
栏目:
临床研究
出版日期:
2023-02-05

文章信息/Info

Title:
Effect of Naoxintong capsule combined with compound troxerutin and porcine cerebroside injection in the treatment of patients with cerebral infarction in convalescent stage
作者:
范小虹; 余德玲; 祁 蕙
(成都市第六人民医院,四川 成都 610051)
Author(s):
FAN Xiaohong; YU Deling; QI Hui
(Chengdu Sixth People's Hospital,Chengdu 610051,China)
关键词:
脑梗死;  脑心通胶囊;  复方曲肽注射液;  血管内皮生长因子;  脑源性神经营养因子;  神经元特异性烯醇化酶
Keywords:
Cerebral infarction;  Naoxintong capsule;  Compound troxerutin and porcine cerebroside injection;  Vascular endothelial growth factor;  Brain-derived neurotrophic factor;  Neuron-specific enolase
分类号:
R 743.33
DOI:
DOI:10.3969/j.issn.1000-7369.2023.02.011
文献标志码:
A
摘要:
目的:探讨脑心通胶囊联合复方曲肽注射液治疗脑梗死恢复期的疗效及对患者血清血管内皮生长因子(VEGF)、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)水平的影响。方法:选取107例脑梗死恢复期患者,随机分为观察组54例和对照组53例。对照组给予复方曲肽注射液治疗,观察组在对照组的基础上给予脑心通胶囊治疗,比较两组临床疗效,简氏Fugl-Meyer评定量表(FMA)评分、美国国立卫生院卒中量表(NIHSS)评分、VEGF、BDNF、NSE、白细胞介素6(IL-6)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、全血黏度(高切、低切)和纤维蛋白原水平。结果:观察组的总有效率高于对照组(P<0.05); 治疗后,观察组FMA评分高于对照组,NIHSS评分低于对照组(P<0.05)。观察组VEGF、BDNF水平高于对照组,NSE水平低于对照组(P<0.05); 观察组IL-6、hs-CRP、TNF-α水平低于对照组(P<0.05); 观察组高切和全血低切黏度、纤维蛋白原低于对照组(P<0.05)。结论:脑心通胶囊联合复方曲肽注射液治疗脑梗死恢复期患者的疗效显著,可有效改善患者神经功能、运动功能和血管内皮功能,抑制炎症反应,降低血液黏度和纤维蛋白原。
Abstract:
Objective:To explore the effect of Naoxintong capsule combined with compound troxerutin and porcine cerebroside injection in the treatment of patients with cerebral infarction in convalescent stage and the effect on levels of serum vascular endothelial growth factor(VEGF),Brain-derived neurotrophic factor(BDNF),and neuron-specific enolase(NSE).Methods:A total of 107 patients with cerebral infarction in convalescent stage were enrolled as the research objects.Randomly divided they into observation group(n=54)and control group(n=53).The control group was given compound troxerutin and porcine cerebroside injection treatment,and observation group was treated with Naoxintong capsules on basis of control group.The clinical curative effect,Fugl-Meyer assessment scale(FMA)score,national institutes of health stroke scale(NIHSS)score,serum VEGF,BDNF,NSE,interleukin 6(IL-6),hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α),whole blood viscosity(high shear,low shear),and fibrinogen in both groups were compared.Results:The overall effective of observation group was higher than that of control group(P<0.05).After 6 weeks of treatment,FMA score in observation group was higher than that of control group,and NIHSS score was lower than that of control group(P<0.05).The levels of VEGF、BDNF were higher than those in control group,and NSE were lower than those in the control group(P<0.05).The levels of IL-6,hs-CRP,TNF-α,were lower than those in control group(P<0.05).The levels of high shear and low shear viscosity,fibrinogen in observation group were lower than those in control group(P<0.05).Conclusion:Effect of Naoxintong capsule combined with compound troxerutin and porcine cerebroside injection is significant in the adjuvant treatment of patients with cerebral infarction in convalescent stage,which can recovering nerve function,motor function and vascular endothelial function,inhibiting inflammatory response,and reducing blood viscosity and fibrinogen.

参考文献/References:

[1] Li N,Wang X,Sun C,et al.Change of intestinal microbiota in cerebral ischemic stroke patients[J].BMC Microbiology,2019,19(1):1-8.
[2] Li L,Scott CA,Rothwell PM,et al.Trends in stroke incidence in high-income countries in the 21st century:Population-based study and systematic review[J].Stroke,2020,51(5):1372-1380.
[3] 吴佐军,董金凤,杨 杨,等.2002—2019年天津市蓟州区缺血性脑卒中死亡率趋势分析[J].中国慢性病预防与控制,2021,29(7):544-547.
[4] Sun Z,Xu Q,Gao G,et al.Clinical observation in edaravone treatment for acute cerebral infarction[J].Nigerian Journal of Clinical Practice,2019,22(10):1324.
[5] 梁 影,石秀芳.血管内皮生长因子和脂蛋白相关磷脂酶A2在脑梗死合并2型糖尿病患者中的表达及意义[J].陕西医学杂志,2020,49(12):1620-1623.
[6] 白金娟,田 龙,张红利.复方曲肽注射液联合降纤酶治疗急性脑梗死的临床研究[J].现代药物与临床,2020,35(2):247-251.
[7] 刘 莹,于生元,顾 平,等.复方曲肽注射液治疗急性缺血性脑卒中400例:多中心回顾性研究[J].武汉大学学报:医学版,2022,43(5):781-786,792.
[8] 杨 曦,姜 黎,杨文友,等.依达拉奉注射液联合脑心通胶囊治疗气虚血瘀型急性脑梗死的临床疗效观察[J].中西医结合心脑血管病杂志,2020,18(24):4249-4252.
[9] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[10] 李 平,吴钟璇,张云如,等.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报,1996,19(1):55-56.
[11] 聂鹏坤,杨 华,赵晓峰,等.中风患者Fugl-Meyer运动功能量表评价一致性检验[J].辽宁中医杂志,2009,36(11):1827-1829.
[12] Ortiz GA,Sacco RL.National institutes of health stroke scale(nihss)[J].Wiley Encyclopedia of Clinical Trials,2007,8:1-9.
[13] 全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383.
[14] 杜茜茜,杨 铭.醒脑开窍针刺法联合西医常规治疗对糖尿病合并亚急性期脑梗死患者神经功能、血脂、炎症因子及血糖的影响[J].陕西中医,2021,42(4):523-526.
[15] Lyden PD,Lu M,Levine SR,et al.A modified national institutes of health stroke scale for use in stroke clinical trials:Preliminary reliability and validity[J].Stroke,2001,32(6):1310-1317.
[16] 宁为民,伍小玲,杨康强,等.急性脑梗死中医证候学研究概况[J].现代中西医结合杂志,2020,29(11):1232-1235.
[17] 胡汉楚,张 征,王赤华.芪独合剂改善缺血性脑卒中恢复期患者神经缺损程度、颈动脉粥样硬化、血管内皮生长因子临床研究[J].陕西中医,2020,41(1):24-28.
[18] Yu L,Liu S,Zhou R,et al.Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats[J].The FASEB Journal,2022,36(4):22263.
[19] Wang Y,Yuan S,Ma X,et al.Effect of rehabilitation in combination with hyperbaric oxygen treatment on the secretion of neurotrophic factors and oxidative stress in recovery phase of cerebral infarction patients[J].Indian Journal of Pharmaceutical Sciences,2021,83(2):166-170.
[20] Ni T,Fu Y,Zhou W,et al.Carotid plaques and neurological impairment in patients with acute cerebral infarction[J].PLoS One,2020,15(1):226961.

相似文献/References:

[1]郭 辉,裴 育,熊伟华,等.血府逐瘀汤联合阿替普酶静脉溶栓对急性脑梗死患者 神经功能及日常生活能力的影响*[J].陕西中医,2019,(2):214.
　GUO Hui,PEI Yu,XIONG Weihua,et al.Effect of Xuefu Zhuyu decoction combined with intravenous thrombolysis on the neurological function and activities of daily living in patients with acute cerebral infarction[J].,2019,(2):214.
[2]陈 晨.补阳还五汤对急性脑梗死患者血管内皮生长因子、血管生成素2及神经功能影响的研究*[J].陕西中医,2019,(1):28.
[3]王艳民.开窍活血汤对脑梗死患者血清前白蛋白、MCP1及MMP9的影响*[J].陕西中医,2019,(1):34.
[4]贾东佩,李春雷△.调神通络针刺法对脑梗死后血管性痴呆患者血清BDNF、VEGF、MMP9的影响*[J].陕西中医,2019,(1):119.
　JIA Dongpei,LI Chunlei..Effect of Tiaoshen Tongluo acupuncture in patients with vascular dementia after cerebral infarction and its effects on serum BDNF, VEGF and MMP9[J].,2019,(2):119.
[5]周志梅,买 雷,李艳红.消栓肠溶胶囊治疗脑梗死疗效及对患者NIHSS评分的影响*[J].陕西中医,2019,(6):696.
　ZHOU Zhimei,MAI Lei,LI Yanhong..Effect of Xiaoshuan enteric-coated capsule on patients with cerebral infarction and its influence on NIHSS score of patients[J].,2019,(2):696.
[6]项广宇.化痰通络方治疗短暂性脑缺血发作后脑梗死疗效及对患者氧化应激和血清相关细胞因子水平的影响*[J].陕西中医,2019,(7):864.
[7]陈 静,陈 炜,伍 媛,等.小续命汤及其组分治疗急性脑梗死研究进展*[J].陕西中医,2019,(12):1818.
[8]赵月臣,马 兰.痰瘀阻络方联合丁苯酞治疗脑梗死急性期疗效及对患者脑血流灌注及血清6-k-PGF1a、Hcy、sICAM-1水平影响*[J].陕西中医,2020,(2):174.
　ZHAO Yuechen,MA Lan..Effect of phlegm stasis blocking collateral combined with butylphthalide on cerebral blood flow perfusion and serum 6-k-PGFla,Hcy and sICAM-1 level in patients with acute cerebral infarction[J].,2020,(2):174.
[9]黄英媛,宋振华△,徐焕杰,等.补阳还五汤联合梅花针叩刺治疗脑梗死偏瘫疗效研究*[J].陕西中医,2020,(6):815.[doi:DOI:10.3969/j.issn.10007369.2020.06.033]
　HUANG Yingyuan,SONG Zhenhua,XU Huanjie,et al.Clinical effect of Buyang Huanwu decoction combined with plum flower needle tapping on cerebral infarction hemiplegia[J].,2020,(2):815.[doi:DOI:10.3969/j.issn.10007369.2020.06.033]
[10]韩 慧,赖智勇,蒲建萍,等.头穴丛刺法联合川芎嗪对大鼠脑梗死后神经元突触重建的影响*[J].陕西中医,2020,(7):860.[doi:DOI:10.3969/j.issn.10007369.2020.07.006]
　HAN Hui,LAI Zhiyong,PU Jianping,et al.Effect of scalp acupuncture combined with ligustrazine on synaptic reconstruction of neurons after cerebral infarction in rats[J].,2020,(2):860.[doi:DOI:10.3969/j.issn.10007369.2020.07.006]

备注/Memo

备注/Memo:
基金项目:四川省中医药管理局课题(2020JC0013)
更新日期/Last Update: 2023-02-08