[1]吴 迪,李文彬,闫小宁,等.基于“心部于表”理论探析银屑病[J].陕西中医,2023,(3):348-351.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.018]
 WU Di,LI Wenbin,YAN Xiaoning,et al.Mechanism of psoriasis based on theory of “heart on the surface”[J].,2023,(3):348-351.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.018]
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基于“心部于表”理论探析银屑病
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年3期
页码:
348-351
栏目:
长安医学
出版日期:
2023-03-05

文章信息/Info

Title:
Mechanism of psoriasis based on theory of “heart on the surface”
作者:
吴 迪1李文彬2闫小宁2黄雪英1
(1.陕西中医药大学,陕西 咸阳 712046; 2.陕西省中医医院,陕西 西安 710003)
Author(s):
WU DiLI WenbinYAN XiaoningHUANG Xueying
(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
关键词:
银屑病 黄帝内经 心部于表 心主血脉 从心论治 四物汤
Keywords:
Psoriasis Huangdi Neijing Heart is on the surface Heart governs blood Treat from the heart Siwu decoction
分类号:
R 758.63
DOI:
DOI:10.3969/j.issn.1000-7369.2023.03.018
文献标志码:
A
摘要:
银屑病是皮肤科常见病之一,以临证为契机,基于《黄帝内经》“心部于表”理论,探析“心”与银屑病的关系。病机方面,心主神明功能失常,可致神失内守,统率失常而发病,且心神失常可贯穿整个病程; 心主血脉功能失常,心血不足,无力推动血运,可致血瘀而发病; 心为阳脏,火邪炎上太过可致血热而发病; 心阳不足,气化无力,体表失于濡润可致血燥而发病。治疗方面,心主血脉可化生心阳、滋养心神、充养皮肤,治疗总以四物汤为底方,分治以清热之凉血四物汤、祛瘀之桃红四物汤、滋阴之当归饮子,以期为临床诊治提供新的思路。
Abstract:
soriasis is one of the common diseases in dermatology.Taking clinical symptoms as an opportunity,based on the theory of the heart is on the surface in the Huangdi Neijing,the pathogenesis of psoriasis caused by the absence of the heart is analyzed.In terms of pathogenesis:the dysfunction of the heart governing the gods can cause the spirit to lose its inner guard,the disorder of command and control,and the onset of the disease,and the disorder of the mind can run through the entire course of the disease.The dysfunction of the heart governing the blood vessels,insufficiency of heart blood,inability to promote blood circulation,can cause blood stasis and the onset of the disease.The heart is a yang viscera,and too much fire and inflammation can lead to blood heat and the disease; deficiency of heart yang,inability to transform qi,and loss of moisturizing the body surface can lead to blood dryness and the disease.In terms of treatment:the blood vessels that govern the heart can be transformed into heart yang,nourish the mind,and nourish the skin.Based on Siwu decoction,according to the development of the disease,use Liangxue Siwu decoction to clear the heat and cool the blood,Taohong Siwu decoction activate blood to dispel stasis,Danggui Yinzi decoction nourish blood and moisturize.In order to provide new ideas for clinical diagnosis and treatment.

参考文献/References:

[1] 赵 辨.临床皮肤病学[M].南京:江苏科学技术出版社,1981:1104-1126.
[2] 许 慎.说文解字[M].北京:中华书局,1963:132,170.
[3] 李春生.“心部于表”理论在新感温热病和皮表疾病治疗中的应用[J].中医杂志,2015,56(12):1022-1025.
[4] 江雅宜,岳仁宋,周建龙.基于《黄帝内经》“心部于表”探讨鼻鼽病机[J].中国中医基础医学杂志,2020,26(11):1593-1594,1597.
[5] 毕 榕,张 泉,刘晋利,等.心主神明论与心脑疾病关系的研究进展[J].中西医结合心脑血管病杂志,2007,5(4):333-335.
[6] Evers AW,Verhoeven EW,Kraaimaat FW,et al.How stress gets under the skin:Cortisol and stress reactivity in psoriasis[J].Br J Dermatol,2010,163(2):986-991.
[7] Zhang Y,Zhang HY,Jiang B,et al.A promising therapeutic target for psoriasis:Neuropeptides in human skin[J].Int Immunopharmacol,2020,87(10):1067-1075.
[8] Wang Y,Li P,Zhang L,et al.Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production[J].J Leukoc Biol,2020,108(1):267-281.
[9] 王晓旭,肖士菊,吕宏蓬,等.从脑皮通路探讨心理应激与银屑病发病的病理机制[J].中国中西医结合皮肤性病学杂志,2021,20(6):647-650.
[10] 北京中医医院.赵炳南临床经验集[M].北京:人民卫生出版社,2006:270.
[11] 何春燕,代 丹,栾 冰,等.朱仁康先生从卫气营血论治皮肤病经验拾萃[J].中华中医药杂志,2021,36(11):6504-6507.
[12] 冯 雷,黄美兴,雷水生,等.血管生成标志物在进行期银屑病皮损中的表达[J].上海医学,2021,44(12):902-906.
[13] Jensen JM,Proksch E.The skin's barrier ital dermatol venereol[J].Giornale Italiano di Dermatologia Evenereologia,2009,144(6):689-700.
[14] 潘云雷,方 红.皮肤屏障功能的改变与银屑病[J].中国皮肤性病学杂志,2018,32(12):1442-1446.
[15] Orsmond A,Bereza ML,Lynch T,et al.Skin barrier dysregulation in psoriasis[J].Int J Mol Sci,2021,22(19):10841.
[16] Nai J,Zhang C,Shao H,et al.Extraction structure pharmacological activities and drug carrier applications of angelica sinensis polysaccharide[J].Int J Biol Macromol,2021,183(11):2337-2353.
[17] Zhang Y,Zhou X,Sun L.Effect of total glucosides of paeony on imiquimod-induced psoriatic skin lesions by regulating VEGF[J].Clin Cosmet Investig Dermatol,2021,14(10):1889-1897.
[18] 张宇虹,郭在培,焦晓燕,等.白芍总苷对轻、中度寻常性银屑病患者血清中IL-17和IL-23的影响[J].中国皮肤性病学杂志,2012,26(5):391-392,398.
[19] 刘 丹,杨晓波,王 颖,等.四物汤对小鼠化疗所致贫血的恢复作用及其机制[J].吉林大学学报:医学版,2018,44(6):1115-1119.
[20] 郭 平,王升启.四物汤对血虚证小鼠骨髓细胞IL-6和IL-18基因表达的影响[J].山东中医杂志,2013,32(4):272-274.
[21] 梁 涢.四物汤对脑缺血再灌注小鼠海马结构及脑组织SOD和GSH-PX活力的影响[J].西部中医药,2017,30(2):10-12.
[22] 吴 玲.凉血四物汤对寻常型(血热型)银屑病患者血浆中CD4+、CD25+、Treg、sIL-2R表达的影响[D].合肥:安徽中医药大学,2018.
[23] 陈 曦.凉血四物汤治疗血热型银屑病的临床疗效观察及对外周血CD4+、CD8+T淋巴细胞的影响研究[D].合肥:安徽中医药大学,2017.
[24] 向聪莲,陈海明,黎 莉,等.桃红四物汤治疗银屑病的网络药理学作用机制[J].中药新药与临床药理,2020,31(6):685-693.
[25] 魏 巍.当归饮子加减联合中药药浴治疗静止期银屑病的临床观察[D].哈尔滨:黑龙江中医药大学,2016.
[26] 文 谦,黄 刚,杨志波,等.当归饮子对银屑病模型豚鼠皮肤Filaggrin和Caspase-14基因及蛋白表达的影响[J].新疆医科大学学报,2016,39(4):418-421.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(82174386); 陕西省重点产业创新链项目(2019ZDLSF04-08); 长安医学成氏皮肤病学术流派传承工作室项目[陕中医药发(2018)40号]
更新日期/Last Update: 2023-03-13