[1]魏代浩,张 茜,魏皓月,等.基于葡萄糖激酶探讨“脾虚燥热”与血糖稳态失衡的关系[J].陕西中医,2023,(4):475-478.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.015]
　WEI Daihao,ZHANG Xi,WEI Haoyue,et al.Explore the relationship between the theory of “spleen deficiency and dryness-heat” and the imbalance of blood glucose homeostasis based on glucokinase[J].,2023,(4):475-478.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.015]
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基于葡萄糖激酶探讨“脾虚燥热”与血糖稳态失衡的关系
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年4期
页码:
475-478
栏目:
学术探讨
出版日期:
2023-04-05

文章信息/Info

Title:
Explore the relationship between the theory of “spleen deficiency and dryness-heat” and the imbalance of blood glucose homeostasis based on glucokinase
作者:
魏代浩1; 张 茜1; 魏皓月1; 黄延芹2
(1.山东中医药大学,山东 济南 250014; 2.山东中医药大学附属医院,山东 济南 250014)
Author(s):
WEI Daihao; ZHANG Xi; WEI Haoyue; HUANG Yanqin
(Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
关键词:
2型糖尿病;  脾虚燥热;  葡萄糖激酶;  血糖稳态;  取象比类;  健脾清热
Keywords:
Type 2 diabetes mellitus;  Spleen deficiency and dryness-heat;  Glucokinase;  Blood glucose homeostasis;  Analogy;  Strengthening the spleen and clearing heat
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7369.2023.04.015
文献标志码:
A
摘要:
血糖稳态失衡是2型糖尿病复杂发病机制的共同特征。葡萄糖激酶是机体糖代谢过程中重要的感受器。中医学认为,脾主运化、为中央土以灌四傍,“脾气亏虚、燥热偏盛”是导致血糖稳态失衡的关键病机。葡萄糖激酶调控全身多个器官以维持血糖稳态与中医学“脾”的作用相似。因此,现从葡萄糖激酶出发论述脾虚燥热导致2型糖尿病血糖稳态失衡的现代生物学基础,为健脾清热法防治2型糖尿病提供新的科学内涵。
Abstract:
Imbalance of blood glucose homeostasis is a common feature of the complex pathogenesis of type 2 diabetes mellitus.Glucokinase is the most important sensor in the process of human glucose metabolism.According to traditional Chinese medicine,the spleen is in charge of transportation and transformation,and serves as the central soil to irrigate the four sides.“Deficiency of the spleen and excess of dryness and heat” are the key pathogenesis leading to the imbalance of blood glucose homeostasis.Glucokinase regulates multiple organs to maintain blood glucose homeostasis similar to the role of “spleen” in traditional Chinese medicine.Therefore,this study explored the modern biological basis of the imbalance of blood glucose homeostasis in type 2 diabetes mellitus caused by spleen deficiency and dryness-heat from glucokinase,and provided a new scientific connotation for the prevention and treatment of type 2 diabetes mellitus by strengthening the spleen and clearing heat.

参考文献/References:

[1] Li Y,Teng D,Shi X,et al.Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American diabetes association:National cross sectional study[J].British Medical Journal,2020,369:997.
[2] Ogurtsova K,Fernandes J,Huang Y,et al.IDF diabetes atlas:Global estimates for the prevalence of diabetes for 2015 and 2040[J].Diabetes Res Clin Pract,2017,128:40-50.
[3] 李小英.葡萄糖激酶在葡萄糖稳态中的核心作用[J].中华糖尿病杂志,2019,11(7):500-502.
[4] Sheng CS,Tian J,Miao Y,et al.Prognostic significance of long-term HbA1c variability for all-cause mortality in the ACCORD trial[J].Diabetes Care,2020,43(6):1185-1190.
[5] Li S,Nemeth I,Donnelly L,et al.Visit-to-visit HbA1c variability is associated with cardiovascular disease and microvascular complications in patients with newly diagnosed type 2 diabetes[J].Diabetes Care,2020,43(2):426-432.
[6] 陈伟国,朱萧玲,常 盼,等.2型糖尿病患者冠状动脉狭窄程度危险因素分析[J].陕西医学杂志,2020,49(6):672-674,686.
[7] 王方圆,袁 斌,孙志萍.糖尿病住院患者个性化护理及对血糖影响临床研究[J].陕西医学杂志,2018,47(7):947-949.
[8] 安文蓉,徐云生,黄延芹.基于数据挖掘的健脾消渴方治疗2型糖尿病临床特点与规律分析[J].中华中医药学刊,2020,38(2):191-194.
[9] 潘宗妃,熊莉华.熊莉华教授从脾论治糖尿病经验[J].陕西中医,2020,41(10):1464-1467.
[10] 苗丁山,王鹤亭,刘 桠,等.从脾主运化探讨肠道菌群-胰岛β细胞远程串扰在糖尿病血糖维稳中的作用[J].中医杂志,2021,62(15):1312-1315.
[11] 刘 毅,冯晓桃,王文健.“脾主运化”理论再认识——“脾主运”与“脾主化”之辨析[J].中医杂志,2011,52(15):1264-1266.
[12] 谢兆桃,周卓宁,郑 鹏,等.从中焦论治2型糖尿病患者餐后血糖波动[J].陕西中医,2021,42(6):764-766.
[13] 陈 源,李振华,岳仁宋.基于中医胃肠积热的2型糖尿病论治探微[J].时珍国医国药,2021,32(9):2229-2230.
[14] 钱秋海,程益春,夏丽英.健脾降糖饮治疗糖尿病临床与实验研究[J].中医杂志,1991,35(11):29-31.
[15] 周 洁,徐云生,李捷,等.健脾消渴方调控自噬改善2型糖尿病大鼠胰岛功能的机制[J].中华中医药杂志,2021,36(8):4556-4560.
[16] Rajas F,Gautier-Stein A,Mithieux G.Glucose-6 phosphate,a central hub for liver carbohydrate metabolism[J].Metabolites,2019,9(12):282.
[17] Toulis KA,Nirantharakumar K,Pourzitaki C,et al.Glucokinase activators for type 2 diabetes:Challenges and future developments[J].Drugs,2020,80(5):467-475.
[18] Matschinsky FM,Wilson DF.The central role of glucokinase in glucose homeostasis:A perspective 50 years after demonstrating the presence of the enzyme in islets of langerhans[J].Front Physiol,2019,10:148.
[19] Gao Q,Zhang W,Li T,et al.The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus:A meta-analysis[J].Medicine,2021,100(40):e27476.
[20] Choi JM,Seo MH,Kyeong HH,et al.Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase[J].Proc Natl Acad Sci U S A,2013,110(25):10171-10176.
[21] Postic C,Shiota M,Niswender KD,et al.Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase[J].J Biol Chem,1999,274(1):305-315.
[22] Oh YS,Lee YJ,Park K,et al.Treatment with glucokinase activator,YH-GKA,increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells[J].Eur J Pharm Sci,2014,51:137-145.
[23] Oh YS,Seo E,Park K,et al.Compound 19e,a novel glucokinase activator,protects against cytokine-induced beta-cell apoptosis in INS-1 cells[J].Front Pharmacol,2017,8:169.
[24] Fyfe MC,White JR,Taylor A,et al.Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions[J].Diabetologia,2007,50(6):1277-1287.
[25] Tomas A,Jones B,Leech C.New insights into beta-cell GLP-1 receptor and cAMP signaling[J].J Mol Biol,2020,432(5):1347-1366.
[26] 张 鹤,白宇宁,刘绍能,等.现代医学视角下中医“脾主运化”探析[J].北京中医药,2022,41(2):179-181.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81974562,81603613); 泰山学者工程专项课题(TSQN202211354); 济南市科技创新计划项目(202019029); 钱秋海全国名老中医药专家传承工作室建设项目[国中医药人教函(2022)75号]
更新日期/Last Update: 2023-04-10