[1]张燕洁,李晓玲,张莹雪,等.健脾活血利水法治疗肝硬化腹水Meta分析[J].陕西中医杂志,2023,(6):801-807.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.027]
　ZHANG Yanjie,LI Xiaoling,ZHANG Yingxue,et al.A Meta-analysis of the basic treatment of Jianpi Huoxue Lishui method in the treatment of ascites in cirrhosis[J].,2023,(6):801-807.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.027]
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健脾活血利水法治疗肝硬化腹水Meta分析
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年6期
页码:
801-807
栏目:
Meta分析
出版日期:
2023-06-05

文章信息/Info

Title:
A Meta-analysis of the basic treatment of Jianpi Huoxue Lishui method in the treatment of ascites in cirrhosis
作者:
张燕洁1; 2; 李晓玲2; 张莹雪1; 2; 李柄邑1; 2; 孙凤霞2
(1.北京中医药大学,北京100029; 2.首都医科大学附属北京中医医院,北京100010)
Author(s):
ZHANG Yanjie; LI Xiaoling; ZHANG Yingxue; LI Bingyi; SUN Fengxia
(Beijing University of Chinese Medicine,Beijing 100029,China)
关键词:
肝硬化腹水;  健脾活血利水法;  鼓胀;  腹围;  腹腔积液深度
Keywords:
Cirrhotic ascites;  Jianpi Huoxue Lishui method;  Tympanites;  Abdominal circumference;  Depth of ascites
分类号:
R 575.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.06.027
文献标志码:
A
摘要:
目的:系统评价依据中医鼓胀基本病理特点而确立的治法“健脾活血利水法”治疗肝硬化腹水的有效性及安全性。方法:计算机检索国内外数据库,收集健脾活血利水法治疗肝硬化腹水的随机对照研究,提取纳入文献数据并进行质量评价,利用Rev Man 5.4软件对数据进行Meta分析。结果:纳入21项研究,共1906例患者。Meta分析显示:与单纯西医常规治疗相比,联合健脾活血利水法在提升肝硬化腹水临床总有效率[OR=4.02,95%CI(3.04,5.30),P<0.00001],改善24 h尿量[MD=256.18,95%CI(164.00,348.36),P<0.00001]、腹围[MD=-4.22,95%CI(-5.15,-3.29),P<0.00001]、腹腔积液深度[MD=-0.52,95%CI(-0.67,-0.36),P<0.00001]方面均显示出优势,而在改善体重方面[MD=-1.28,95%CI(-4.26,1.70),P=0.40]差异无统计学意义。结论:在治疗肝硬化腹水方面,健脾活血利水法联合西医常规疗法,能够有效改善临床症状,增加24 h尿量,减少腹围和腹腔积液深度。
Abstract:
Objective:To systematically evaluate the efficacy and safety of the treatment based on basic pathological characteristics of traditional Chinese medicine “Jianpi Huoxue Lishui” method combined with conventional western medicine in the treatment of ascites due to cirrhosis.Methods:Databases domestic and abroad were searched by computer to collect randomised controlled studies on the treatment of liver cirrhosis with ascites by strengthening the spleen,promoting blood circulation and diverting water.The included literature was extracted and the quality of the data was evaluated.Rev Man 5.4 software was used to carry out Meta-analysis of the data.Results:21 studies were included,with a total of 1906 patients.Meta-analysis showed that compared with conventional western medicine treatment alone,combined with the method of strengthening the spleen and promoting blood circulation and diuresis in improving the total clinical effective rate of liver cirrhosis ascites [OR=4.02,95%CI(3.04,5.30),P<0.00001],improved 24 h urine output [MD=256.18,95%CI(164.00,348.36),P<0.00001],abdominal circumference [MD=-4.22,95%CI(-5.15,-3.29), P<0.00001],depth of ascites [MD=-0.52,95%CI(-0.67,-0.36),P<0.00001] all showed advantages,while in terms of weight improvement [MD=-1.28,95%CI(-4.26,1.70),P=0.40] no significant difference.Conclusion:The method of Jianpi Huoxue Lishui method combined with conventional western medicine therapy in the treatment of liver cirrhosis ascites can effectively improve the clinical symptoms,increase the 24-hour urine volume,and reduce the abdominal circumference and the depth of ascites.

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备注/Memo

备注/Memo:
基金项目:国家科技重大专项“十三五”课题(2018ZX10725-505); 首都卫生发展科研专项课题(2018-2-2173)
更新日期/Last Update: 2023-06-09