[1]谢佳涛,唐梅文,陈文隆,等.胃食管反流病病因病机及治疗研究进展[J].陕西中医,2023,(6):822-封3.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.032]
 XIE Jiatao,TANG Meiwen,CHEN Wenlong,et al.Research progress on etiology,pathogenesis and treatment of gastroesophageal reflux disease[J].,2023,(6):822-封3.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.032]
点击复制

胃食管反流病病因病机及治疗研究进展
分享到:

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年6期
页码:
822-封3
栏目:
综 述
出版日期:
2023-06-05

文章信息/Info

Title:
Research progress on etiology,pathogenesis and treatment of gastroesophageal reflux disease
作者:
谢佳涛1唐梅文12陈文隆1许 琦1周 玲1钟丰羽1古文姝1
(1.广西中医药大学研究生院,广西 南宁 530020; 2.广西中医药大学第一附属医院,广西 南宁 530020)
Author(s):
XIE JiataoTANG MeiwenCHEN WenlongXU QiZHOU LingZHONG FengyuGU Wenshu
(Graduate School of Guangxi University of Chinese Medicine,Nanning 530020,China)
关键词:
胃食管反流病 吐酸 病因病机 肝胃不和 抑酸
Keywords:
Gastroesophageal reflux disease Acid regurgitation Etiology and pathogenesis Disharmony between liver and stomach Acid suppression
分类号:
R 571
DOI:
DOI:10.3969/j.issn.1000-7369.2023.06.032
文献标志码:
A
摘要:
胃食管反流病(GERD)是临床上较为常见的消化系统疾病,因其病程反复、迁延难愈等特点而严重地影响了患者的生活及心理。现阶段,GERD的发病机制存在复杂性和不确定性,笔者通过对近几年中西医病因病机及治疗相关文献收集整理,笔者发现西医认为GERD的发病机制与食管下括约肌(LES)抗反流屏障结构障碍、食管对胃反流物的廓清功能异常等相关,治疗以抑酸、促进胃肠动力及抗反流手术等为主。古今中医医家则认为在多因素下致肝胃不和、气机失和为其总病机,在治疗方面,通过辨证分型采用药物疗法、中医外治法治疗等。现笔者通过收集整理近几年国内外GERD文献资料,阐述了中西医学者对GERD的病因病机和治疗两方面的认识,以期为治疗GERD进展的研究提供参考。
Abstract:
Gastroesophageal reflux disease(GERD),which is a common digestive system disease in clinic,which seriously affects patients's life and psychology on account of its repeated course and difficult recovery.At present,the pathogenesis of GERD is complicated and uncertain.By collecting and sorting out the relevant literature about etiology,pathogenesis and treatment of traditional Chinese and western medicine in recent years.The author finds that western medicine thinks that the pathogenesis of GERD is related to the structural disorder of the lower esophageal sphincter(LES)anti-reflux barrier and the abnormal clearance function of esophagus to gastric reflux.And the treatments are mainly acid suppression,gastrointestinal motility promotion and anti-reflux surgery.Ancient and modern Chinese medicine doctors believe that disharmony between liver and stomach and disharmony between qi and blood are the general pathogenesis.In terms of treatment,drug therapy and external treatment of traditional Chinese medicine are adopted by syndrome differentiation and classification.By collecting and sorting out the literature of GERD at home and abroad in recent years,the author expounds the understanding of etiology,pathogenesis and treatment of GERD by Chinese and western scholars,in order to provide reference for the research on the progress of treating GERD.

参考文献/References:

[1] Yadlapati R,Gyawali CP,Pandolfino JE,et al.AGA clinical practice update on the personalized approach to the evaluation and management of GERD:Expert review[J].Clin Gastroenterol Hepatol,2022,20(5):984-994.
[2] Maret-Ouda J,Markar SR,Lagergren J.Gastroesophageal reflux disease:A review[J].JAMA,2020,324(24):2536-2547.
[3] 张声生,朱生樑,王宏伟,等.胃食管反流病中医诊疗专家共识意见(2017)[J].中国中西医结合消化杂志,2017,25(5):321-326.
[4] Patel A,Yadlapati R.Diagnosis and management of refractory gastroesophageal reflux disease[J].Gastroenterol Hepatol(N Y),2021,17(7):305-315.
[5] Zhang B,Wang Y,Liao Y,et al.Advances in the diagnosis and treatment of achalasia of the cardia:A review[J].J Transl Int Med,2021,9(1):24-31.
[6] Hashimoto R,Chang KJ.Minimizing reflux after peroral endoscopic myotomy:Navigational pocket technique[J].Endoscopy,2020,52(8):277-278.
[7] Shiwaku H,Sato H,Shimamura Y,et al.Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy:A large-scale multicenter cohort study in Japan[J].Endoscopy,2022,54(9):839-847.
[8] Weyhe D,Uslar V,Kuhne J,et al.Hiatus hernie:Standards and controversies in diagnostics and treatment[J].Chirurg,2019,90(4):331-348.
[9] 薛 锋,廖和和,王鹏国,等.胸腔镜辅助下膈疝修补术临床研究[J].陕西医学杂志,2018,47(2):199-201,205.
[10] 聂玉胜,熊 尧,杨慧琪,等.不同类型补片在食管裂孔疝修补术中应用的研究[J].中华普通外科杂志,2022,37(2):104-107.
[11] 雷 霞,张耀平,冯 洁,等.一过性食管下括约肌松弛的影响因素[J].医学综述,2022,28(1):100-104.
[12] 李勉力,唐旭东,李海文,等.中药复方治疗胃食管反流病作用机制探讨[J].世界中医药,2022,17(15):2112-2116.
[13] Hung JS,Yi CH,Liu TT,et al.Effects of GABA-B agonist baclofen on esophageal motility:Studies using high-resolution manometry[J].Neurogastroenterol Motil,2019,31(12):13716.
[14] 尤丽财,肖丽晶.胃食管反流合并难治性咳嗽患者食管动力及括约肌功能特点分析[J].中外医疗,2020,39(3):58-60.
[15] Yadlapati R,Kahrilas PJ.Esophageal motility disorders on high-resolution manometry:Chicago classification version 4.0[J].Neurogastroenterol Motil,2021,33(1):14058.
[16] 杨莉丽,邓兴明,张燕燕,等.难治性胃食管反流病食管动力及反流特点的临床分析[J].中国医学创新,2021,18(9):142-145.
[17] Jonsson R,Brokstad KA,Jonsson MV,et al.Current concepts on Sjogren's syndrome-classification criteria and biomarkers[J].Eur J Oral Sci,2018,126(1):37-48.
[18] 肖棋予,罗 雯.注射用氨磷汀用于分化型甲状腺癌放射性碘131治疗前对唾液腺的保护作用[J].临床合理用药杂志,2020,13(26):104-106.
[19] 唐武儒,韦 嵩,张发恩,等.99mTcO4-唾液腺动态显像评价头颈部肿瘤放射治疗对唾液腺功能的影响[J].中国医学物理学杂志,2019,36(6):701-704.
[20] 崔田宁,张霓霓,龙远铸,等.低氧预处理人羊膜间充质干细胞外泌体修复放射性损伤唾液腺的实验研究[J].口腔医学研究,2022,38(12):1145-1150.
[21] Nejat PK,Qujeq D,Maghsoudi H.Some of the effective factors in the pathogenesis of gastro-oesophageal reflux disease[J].J Cell Mol Med,2018,22(12):6401-6404.
[22] Ustaoglu A,Nguyen A,Spechler S,et al.Mucosal pathogenesis in gastro-esophageal reflux disease[J].Neurogastroenterol Motil,2020,32(12):e14022.
[23] Wheeler JC,Vanoni S,Zeng C,et al.17β-estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling[J].J Allergy Clin Immunol,2019,143(6):2131-2146.
[24] Wu J,Liu D,Feng C,et al.The characteristics of postprandial proximal gastric acid pocket in gastroesophageal reflux disease[J].Med Sci Monit,2018,24:170-176.
[25] Wilkinson J,Abd-Elaziz K,Daas I,et al.Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation(gaviscon double action)[J].Drug Dev Ind Pharm,2019,45(3):430-438.
[26] Ehlers AP,Bonham AJ,Ghaferi AA,et al.Impact of hiatal hernia repair technique on patient-reported gastroesophageal reflux symptoms following laparoscopic sleeve gastrectomy[J].Surg Endosc,2022,36(9):6815-6821.
[27] Altuwaijri M.Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy:A review[J].Medicine(Baltimore),2022,101(35):30487.
[28] 袁光辉,徐 艺.刘沈林从郁论治胃食管反流病之经验[J].江苏中医药,2022,54(9):23-25.
[29] 孙 涛,谢晶日,张 冰.谢晶日运用“肝脾同调”治疗胃食管反流病经验探析[J].辽宁中医杂志,2022,49(9):32-34.
[30] 孙佳琳,张声生,朱春洋.张声生教授从“胃以降为顺”论治胃食管反流病的经验[J].天津中医药,2021,38(1):29-33.
[31] 赫连晓彤,王伟明.王文正从脾肾论治胃食管反流病经验[J].山东中医杂志,2022,41(6):660-663,690.
[32] 刘佳丽,张 阳,谢春娥,等.李军祥教授从太极升降论治胃食管反流病临床经验撷要[J].中国中西医结合消化杂志,2020,28(3):227-229.
[33] 刘凯娟,李维康,王力普,等.李佃贵从“五脏”论治难治性反流性食管炎经验[J].陕西中医,2020,41(8):1144-1147.
[34] 周 燕,李保良,曾 志,等.建中降逆汤治疗非糜烂性胃食管反流病中虚气逆证临床研究[J].陕西中医,2022,43(6):740-743.[35] 孙叙敏,张雅月,尹 璐.柴胡疏肝散合旋覆代赭汤加减治疗伴焦虑、抑郁的胃食管反流病的临床疗效[J].中国实验方剂学杂志,2021,27(8):88-93.[36] 张 媛,李永娟,崔云凤,等.荜铃胃痛颗粒联合雷贝拉唑治疗对胃食管反流病临床效果、症候积分及GERDQ评分的影响[J].解放军医药杂志,2022,34(5):125-128.[37] 何 婧,王 毅,周 竞,等.艾司奥美拉唑联合穴位针灸治疗中虚气逆型胃食管反流病的临床观察[J].世界中西医结合杂志,2021,16(6):1079-1083,1088.[38] 郑伟伟,陈冰冰,何 璠.针药并用治疗胃食管反流病肝胃郁热证的疗效及作用机制[J].北京中医药,2023,42(1):111-115.[39] 张 艳,陈 锋,贾月惠.旋覆四磨合剂联合穴位埋线治疗胃食管反流病[J].中国中西医结合消化杂志,2019,27(11):865-867.

相似文献/References:

[1]赵智宏,徐 杰.从中医脏腑八纲辨证理论探讨胃食管反流病的病机及治疗方法[J].陕西中医,2019,(4):515.
 ZHAO Zhihong,XU Jie..Discussion on the pathogenesis and treatment of gastroesophageal reflux disease from the dialectical theory of the eight principles of the internal organs of traditional Chinese medicine[J].,2019,(6):515.
[2]陈利民,牛聪慧,陆一兰.柴胡左金汤辨证治疗胃食管反流病疗效研究[J].陕西中医,2019,(8):1091.
 CHEN Limin,NIU Conghui,LU Yilan..Clinical effect on patients with gastroesophageal reflux disease treated with Chaihu Zuojin decoction[J].,2019,(6):1091.
[3]蔡翠珠,黄少君,曾露慧,等.降逆益中汤治疗胃食管反流病疗效及对患者血清炎性因子的影响*[J].陕西中医,2020,(11):1569.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.014]
 CAI Cuizhu,HUANG Shaojun,ZENG Luhui,et al.Curative effect of Jiangni Yizhong decoction on gastroesophageal reflux disease and its effect on serum inflammatory factors[J].,2020,(6):1569.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.014]
[4]孟 淼,李珊珊,佟 喆.降逆益中汤治疗胃食管反流病临床研究[J].陕西中医,2022,(7):884.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.016]
 MENG Miao,LI Shanshan,TONG Zhe.Clinical study on Jiangni Yizhong decoction for gastroesophageal reflux disease[J].,2022,(6):884.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.016]
[5]顾世坦,周正华,冀建斌,等.胃食管反流病中医辨治探析[J].陕西中医,2022,(8):1078.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.022]
 GU Shitan,ZHOU Zhenghua,JI Jianbin,et al.Discussion on treatment of gastroesophageal reflux disease by traditional Chinese medicine[J].,2022,(6):1078.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.022]
[6]李英宵,张开波,张璐鹏,等.针刺治疗胃食管反流病研究进展[J].陕西中医,2022,(8):1147.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.038]
 LI Yingxiao,ZHANG Kaibo,ZHANG Lupeng,et al.Research progress of acupuncture in the treatment of gastroesophageal reflux disease[J].,2022,(6):1147.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.038]
[7]李牛牛,张俊立,刘亚军,等.基于“脑肠轴”探讨中药复方治疗胃食管反流病研究进展[J].陕西中医,2024,(4):570.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.031]
 LI Niuniu,ZHANG Junli,LIU Yajun,et al.Research progress in the treatment of gastroesophageal reflux disease with traditional Chinese medicine compound based on the “brain gut axis”[J].,2024,(6):570.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.031]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81760862)
更新日期/Last Update: 2023-06-09