[1]蒲 瑾,孟 凯,童春颖,等.清肺蠲饮汤联合西药治疗肺炎热饮阻肺证疗效研究[J].陕西中医,2023,(7):888-891.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.014]
　PU Jin,MENG Kai,TONG Chunying,et al.Effect study on Qingfei Juanyin decoction combined with western medicine in treatment of pneumonia Reyin Zufei syndrome[J].,2023,(7):888-891.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.014]
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清肺蠲饮汤联合西药治疗肺炎热饮阻肺证疗效研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年7期
页码:
888-891
栏目:
临床研究
出版日期:
2023-07-05

文章信息/Info

Title:
Effect study on Qingfei Juanyin decoction combined with western medicine in treatment of pneumonia Reyin Zufei syndrome
作者:
蒲 瑾1; 孟 凯2; 童春颖3; 洪 熙3; 陆城华3; 孙 瑾4
(1.海军军医大学第一附属医院,上海 200433; 2.上海市徐汇区中心医院,上海 200031; 3.上海中医药大学附属龙华医院,上海 200032; 4.上海市普陀区人民医院,上海 200060)
Author(s):
PU Jin; MENG Kai; TONG Chunying; HONG Xi; LU Chenghua; SUN Jin
(The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)
关键词:
肺炎;  热饮阻肺证;  清肺蠲饮汤;  粒细胞集落刺激因子;  可溶性白细胞介素-2受体;  炎症因子
Keywords:
Pneumonia;  Reyin Zufei syndrome;  Qingfei Juanyin decoction;  Granulocyte colony-stimulating factor;  Soluble interleukin-2 receptor;  Inflammatory factor
分类号:
R 563.1
DOI:
DOI:10.3969/j.issn.1000-7369.2023.07.014
文献标志码:
A
摘要:
目的:探究清肺蠲饮汤联合西药治疗肺炎热饮阻肺证疗效及对血清粒细胞集落刺激因子(G-CSF)、可溶性白细胞介素-2受体(sIL-2R)水平的影响。方法:选取102例肺炎患者作为研究对象,采用随机数字表法分为两组,每组51例。对照组给予常规西药治疗,试验组在对照组基础上加服清肺蠲饮汤。比较两组临床疗效、中医证候积分、炎症因子水平及血清G-CSF、sIL-2R水平。结果:两组治疗后中医证候积分均下降,试验组主症及次症积分低于对照组,差异有统计学意义(均P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后血清G-CSF、sIL-2R水平下降,且试验组低于对照组,差异有统计学意义(均P<0.05)。两组治疗后降钙素原(PCT)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平下降,且试验组低于对照组,差异有统计学意义(均P<0.05)。结论:清肺蠲饮汤联合西药治疗肺炎热饮阻肺证疗效较好,可有效降低患者G-CSF、sIL-2R及炎症因子水平。
Abstract:
Objective:To investigate effect of Qingfei Juanyin decoction combined with western medicine on serum granulocyte colony-stimulating factor(G-CSF)and soluble interleukin-2 receptor(sIL-2R)levels in patients with pneumonia Reyin Zufei syndrome.Methods:A total of 102 patients with pneumonia were selected as the study subjects.According to random number table method,the patients were divided into control group and experimental group,with 51 cases in each group.The control group were given conventional western medicine treatment,and the experimental group additionally Qingfei Juanyin decoction.Curative effect,TCM syndrome scores,the levels of serum G-CSF,sIL-2R and inflammatory factor were compared between the two groups.Results:After treatment,TCM syndrome scores of the two groups decreased,the scores for main and secondary syndromes in the experimental group were lower than those in the control group,difference statistically significant(all P<0.05).The treatment effective rate in the experimental group was higher than that in the control group,difference statistically significant(P<0.05).After treatment,the levels of serum G-CSF,sIL-2R,procalcitonin(PCT),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)in the two groups decreased,and above indicators in the experimental group were lower than those in the control group,difference statistically significant(all P<0.05).Conclusion:Qingfei Juanyin decoction combined with western medicine is effective in the treatment of pneumonia Reyin Zufei syndrome,which can significantly reduce the levels of G-CSF,sIL-2R and inflammatory factors.

参考文献/References:

[1] 葛燕萍,王绍谦,孔 静.清肺化痰汤对重症肺炎(痰热壅肺证)患者中医证候积分、免疫功能及炎性因子的影响[J].中国中医急症,2022,31(8):1213-1216.
[2] Wen JN,Li N,Guo CX,et al.Performance and comparison of assessment models to predict 30-day mortality in patients with hospital-acquired pneumonia[J].Chin Med Journal,2020,133(24):2947-2952.
[3] 刘春涛,周景霞,周大鹏,等.黄芪颗粒联合常规治疗对重症肺炎患者的临床疗效[J].中成药,2022,44(1):92-96.
[4] 闫永彬,马淑霞,任献青,等.基于“热饮”理论之清肺蠲饮汤治疗小儿肺炎热饮阻肺证临床研究[J].中国中医基础医学杂志,2017,23(4):510-511.
[5] 陆再英,钟南山.内科学[M].北京:人民卫生出版社,2011:284-292.
[6] 国家中医药管理局.中医病症诊断疗效标准[S].南京:南京大学出版社,1994:19.
[7] 国家食品药品监督管理总局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:121-126.
[8] 辛素芳,李力敏,刘 佩,等.解毒理肺汤辅助治疗儿童肺炎支原体肺炎临床研究[J].陕西中医,2018,39(4):446-448.
[9] 贺红安,王 晓,张葆青.基于网络药理学探讨黄芩-茵陈药对治疗儿童肺炎支原体肺炎的作用机制[J].山东中医杂志,2020,39(12):1353-1360.
[10] 贺 辉,刘正艳,梁丽娜,等.宣肺清毒汤治疗小儿支原体肺炎疗效及对患者血清炎性因子表达水平的研究[J].陕西中医,2019,40(5):627-630.
[11] 崔 颖,高天宇,贾月霞,等.益元清肺汤联合西药对老年重症肺炎(气虚肺热证)呼吸支持患者炎症反应及免疫功能的影响[J].陕西中医,2022,43(7):880-883.
[12] 谷 宽,孙晓舟,田 野,等.孙丽平治疗小儿肺炎喘嗽临床经验[J].吉林中医药,2022,42(2):173-175.
[13] 姚逸临,田建辉,李和根.李和根辨治放射性肺炎经验[J].陕西中医,2018,39(3):390-392.
[14] 赵珍珍,史艳平,邱 锐,等.清热活血方联合阿奇霉素治疗儿童肺炎支原体肺炎临床研究[J].陕西中医,2021,42(5):616-619.
[15] 李如伟,王瑞华,唐碧波,等.血清炎症因子G-CSF、MCP-1、IP-10在支气管肺发育不良患儿中的表达及临床意义[J].广西医科大学学报,2021,38(12):2331-2336.
[16] 蒋玉欢,何本超,郑志刚,等.改良Miccoli微创术联合术后DC-CIK治疗甲状腺癌疗效及对患者血清Gal-3、sIL-2R水平的影响[J].陕西医学杂志,2020,49(11):1417-1421.
[17] 薛海鲸,苏 周.细胞免疫指标与血清hs-CRP、PCT早期鉴别诊断儿童肺炎临床研究[J].陕西医学杂志,2018,47(4):530-532.
[18] 李风峰,康占旺,曾 璐,等.左卡尼汀辅助治疗重症肺炎伴发心力衰竭对患儿炎症细胞及T淋巴细胞水平的影响[J].陕西医学杂志,2020,49(1):56-59.
[19] 张云霞,王征军,阮联英,等.血清hs-CRP、PCT及T细胞亚群在支原体肺炎中的表达及穿心莲内酯磺化物干预的临床疗效[J].中华中医药学刊,2021,39(4):255-258.
[20] 刘佳蕊,杜耀东,崔天怡,等.中医药调控益生菌防治肺炎的研究进展[J].世界科学技术-中医药现代化,2022,24(9):3325-3331.
[21] 冯徐俊.炙麻黄剂量及用药时间差异对慢性阻塞性肺病急性加重期临床疗效的影响[J].中国当代医药,2022,29(16):70-72,75.
[22] 朱 栋,何 翔,李国平.基于网络药理学及分子对接技术探讨中药复方射干麻黄汤治疗咳嗽变异性哮喘的作用机制[J].环球中医药,2023,16(2):210-217.
[23] 王零零,张 鑫.雷火灸联合桂枝茯苓丸治疗慢性盆腔炎的疗效及对TGF-β1/Smads通路的影响[J].中国计划生育学杂志,2023,31(3):515-521.
[24] 赵 芳,余璐璐,徐 辉,等.黄芪桂枝五物汤加味泡洗包在乳腺癌患者紫杉类药物相关周围神经毒性中的临床观察[J].肿瘤综合治疗电子杂志,2023,9(1):38-42.
[25] 谢 锋,段广靖,李 敏,等.基于网络药理学和体外实验探讨附子干姜抗心肌缺血再灌注损伤的作用机制[J].天然产物研究与开发,2023,35(1):151-158.
[26] 王 栋,王晓龙,陈海红,等.基于网络药理学与分子对接探讨甘草干姜汤治疗特发性肺纤维化作用机制[J].山东中医药大学学报,2022,46(3):331-344.
[27] 刘 倩,梅全喜,刘金伟,等.1004张中药饮片处方中细辛的使用情况及其治疗皮肤疾病的临床应用分析[J].中国医院用药评价与分析,2023,23(1):104-107,111.
[28] 黄 山,刘纳文,郝 阳.经方麻黄附子细辛汤合防己黄芪汤减轻膜性肾病小鼠氧化应激损伤的机制研究[J].天津中医药,2022,39(11):1439-1444.

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[2]杨关山,潘永泉△,李 亮,等.婴儿健脾化痰方治疗婴儿肺炎喘嗽临床研究*[J].陕西中医,2019,(7):845.
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备注/Memo

备注/Memo:
基金项目:上海市卫生健康委员会科研项目(ZY-SYJS-3); 上海市社区中医药适宜技术项目(SHGZS-2017012)
更新日期/Last Update: 2023-07-10