[1]孟俊玲,汤 莉.桃红四物汤加减联合助卵泡汤分阶段口服对IVF-ET中卵巢低反应患者卵巢反应性及卵子质量的影响[J].陕西中医,2023,(9):1205-1207.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.010]
　MENG Junling,TANG Li.Effects of phased oral administration of modified Taohong Siwu decoction combined with Zhuluanpao decoction on ovarian response and oocyte quality in patients with poor ovarian response during IVF-ET[J].,2023,(9):1205-1207.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.010]
点击复制

桃红四物汤加减联合助卵泡汤分阶段口服对IVF-ET中卵巢低反应患者卵巢反应性及卵子质量的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年9期
页码:
1205-1207
栏目:
临床研究
出版日期:
2023-09-05

文章信息/Info

Title:
Effects of phased oral administration of modified Taohong Siwu decoction combined with Zhuluanpao decoction on ovarian response and oocyte quality in patients with poor ovarian response during IVF-ET
作者:
孟俊玲; 汤 莉
(桂林市中医医院妇科,广西 桂林 541002)
Author(s):
MENG Junling; TANG Li
(Department of Gynecology,Guilin Hospital of Traditional Chinese Medicine,Guilin 541002,China)
关键词:
卵巢低反应;  妊娠结局;  桃红四物汤;  助卵泡汤;  雌二醇;  孕酮
Keywords:
Poor ovarian response;  Pregnancy outcomes;  Taohong Siwu decoction;  Zhuluanpao decoction;  Estradiol;  Progesterone
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2023.09.010
文献标志码:
A
摘要:
目的:观察桃红四物汤加减联合助卵泡汤分阶段口服对体外受精-胚胎移植(IVF-ET)中卵巢低反应(POR)患者卵巢反应性及卵子质量的影响。方法:将110例IVF-ET中卵巢低反应患者根据治疗方式不同分为58例对照组(常规西药治疗)和52例观察组(对照组基础上+桃红四物汤加减联合自拟助卵泡汤)。比较两组间中医症状积分,HCG注射日雌二醇(E2)、孕酮(P)和抗苗勒氏管激素(AMH)水平,记录两组生化妊娠率和临床妊娠率及不良反应发生情况。结果:治疗后,两组中医症状积分均降低(P<0.05),且观察组中医症状积分显著低于对照组(P<0.05); 注射HCG当日,观察组E2和AMH显著高于对照组(P<0.05),P水平显著低于对照组(P<0.05); 观察组临床妊娠率显著高于对照组(P<0.05),两组间生化妊娠率比较差异无统计学意义(P>0.05); 两组均未发生明显不良反应。结论:桃红四物汤与助卵泡汤联合应用于IVF-ET中POR患者,能有效改善患者临床症状,提高卵巢反应性及卵子质量,改善妊娠结局。
Abstract:
Objective:To observe the effects of phased oral administration of modified Taohong Siwu decoction combined with Zhuluanpao decoction on ovarian response and oocyte quality in patients with low ovarian response during in vitro fertilization and embryo transfer(IVF-ET).Methods:The clinical data of 110 patients with low ovarian response during IVF-ET were retrospectively analyzed,and the patients were divided into 58 cases in control group(conventional western medicine treatment)and 52 cases in observation group(modified Taohong Siwu decoction combined with Zhuluanpao decoction on the basis of control group)according to the different treatment methods.TCM symptoms scores,levels of estradiol(E2),progesterone(P)and anti-Mullerian hormone(AMH)on the day of HCG injection.Biochemical pregnancy rate and clinical pregnancy rate as well as occurrence of adverse reactions were recorded in the two groups.Results:After treatment,the TCM symptoms scores in both groups were decreased(P<0.05),and the scores in observation group were significantly lower than those in control group(P<0.05).On the day of HCG injection,the levels of E2 and AMH in observation group were significantly higher than those in control group(P<0.05),while the P level was significantly lower than that in control group(P<0.05).The clinical pregnancy rate in observation group was significantly higher than that in control group(P<0.05),but there was no statistical significance in biochemical pregnancy rate between the two groups(P>0.05).No obvious adverse reactions occurred in the two groups.Conclusion:Taohong Siwu decoction combined with Zhuluanpao decoction can effectively improve the clinical symptoms,enhance the ovarian response and oocyte quality,and promote the pregnancy outcomes in patients with POR during IVF-ET.

参考文献/References:

[1] 薛 辉,曲 正,任秀英,等.调更益经方改善IVF-ET肾虚血瘀证卵巢低反应患者子宫内膜容受性的临床观察[J].现代中医临床,2022,29(1):5-10.
[2] 谢 璐,姚 俐,陈 烨,等.左五合方对卵巢低反应者IVF/ICSI-ET助孕结局的影响[J].南京中医药大学学报,2019,35(4):395-398.
[3] 张 艳,翁双燕,汤锶锶,等.国医大师段亚亭治疗卵巢低反应的经验[J].中医药导报,2019,25(9):25-27,38.
[4] 陈 赟,周倩茹.何嘉琳.治疗卵巢低反应经验探析[J].浙江中医药大学学报,2020,44(3):259-261.
[5] 张阳阳.控制性超促排卵后卵巢低反应的诊断及治疗[J].国际生殖健康/计划生育杂志,2015,34(6):519-523.
[6] 张建伟.中医妇科学[M].北京:医药科技出版社,2015:102-103.
[7] 中华人民共和国卫生部.中药新药临床研究指导原则试行[M].北京:中国医药科技出版社,2002:361-390.
[8] 卫爱武,肖惠冬子,徐广立,等.定坤丹联合微刺激方案对体外受精-胚胎移植中卵巢低反应临床结局的影响[J].中华中医药学刊,2019,37(9):2224-2228.
[9] 龚绍芹,刘绪荣,张亚婷.补肾健脾壮骨方预防卵巢低反应后骨质疏松效果及相关机制研究[J].陕西中医,2020,41(12):1712-1714.
[10] 安竹青,曾维邓,韩 巍.消癥汤加减辅助治疗气虚血瘀型子宫肌瘤的效果及对患者子宫体积和中医症候积分的影响[J].海南医学,2021,32(22):2928-2931.
[11] 陈 心,杜 清,尤昭玲,等.补肾助卵汤上调雷公藤多苷诱导的卵巢功能低下大鼠的卵巢PLGF及Flt-1水平[J].湖南中医药大学学报,2021,41(11):1683-1688.
[12] 薛 颖,杨艳景,闫 娟,等.补肾活血散瘀汤联合高强度聚焦超声对子宫腺肌病的疗效及病人免疫功能的影响[J].安徽医药,2023,27(1):131-134.
[13] 路 帅,成秀梅,董喜英,等.补肾填精活血通络法对低促性腺激素性腺功能减退引起闭经患者卵巢功能和性激素水平的影响[J].现代中西医结合杂志,2022,31(15):2146-2149.
[14] 田 颖,樊健敏,白永利.补肾活血调经汤对多囊卵巢综合征患者子宫血流变化及激素水平的影响[J].西部中医药,2021,34(8):104-106.
[15] 何秀宣,甘群英.自拟补肾活血汤联合定坤丹治疗多囊卵巢综合征(肾虚血瘀型)临床疗效观察[J].四川中医,2019,37(7):164-167.
[16] 阙晓慧,桂蜀华,钟清元,等.不同炮制程度地黄对小鼠卵巢的影响及其寒热药性相关成分分析[J].中成药,2021,43(11):3222-3226.
[17] 郭丽娟,葛双雷,许 慧,等.微量元素与PCOS患者内分泌代谢、胰岛素抵抗相关性研究[J].中国实验诊断学,2022,26(7):1042-1044.
[18] 周天一,陈瑞雪.从虚论治卵巢储备功能减退思路探析[J].中国临床医生杂志,2022,50(10):1249-1251.
[19] 尚芬芬,丁 青,陆 惠,等.护卵汤配合补佳乐及安宫黄体酮对卵巢早衰模型小鼠卵巢Th17和Treg的影响[J].湖南中医药大学学报,2012,32(9):29-32.
[20] 聂 欣,成颜芬,王 琳,等.桃红四物汤化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析[J].中国实验方剂学杂志,2020,26(4):226-234.

相似文献/References:

[1]董巍巍,段雪涛,王红红,等.六味地黄汤加味联合穴位按摩治疗妊娠期糖尿病疗效及对患者妊娠结局的影响*[J].陕西中医,2020,(4):447.
[2]蔡红霞,丁金玉△,张明恩.四君子汤对妊娠期糖尿病患者血管内皮功能及妊娠结局的影响*[J].陕西中医,2020,(12):1708.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.007]
　CAI Hongxia,DING Jinyu,ZHANG Mingen..Effect of Sijunzi decoction on vascular endothelial function and pregnancy outcome in patients with gestational diabetes mellitu[J].,2020,(9):1708.[doi:DOI:10.3969/j.issn.1000-7369.2020.12.007]
[3]于 委,杜 鑫.基于月经周期的中药汤剂对多囊卵巢综合征患者性激素水平、妊娠结局的影响[J].陕西中医,2021,(1):29.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.006]
　YU Wei,DU Xin.Effect of TCM decoction based on menstrual cycle on levels of sex hormones and pregnancy outcomes in patients with PCOS[J].,2021,(9):29.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.006]
[4]谢 宁,李红岩,韩晓云.加味杞菊地黄汤联合西药治疗子痫前期疗效及对患者外周血sFlt/PIGF和妊娠结局的影响[J].陕西中医,2021,(9):1189.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.009]
　XIE Ning,LI Hongyan,HAN Xiaoyun.Effect of modified Qiju Dihuang decoction combined with western medicine in preeclampsia and its influence on sFlt/PIGF in peripheral blood and pregnancy outcome[J].,2021,(9):1189.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.009]
[5]刘秋杨,朱慧芳,王迎春,等.黄芪四君子汤联合门冬胰岛素治疗妊娠期糖尿病临床研究[J].陕西中医,2021,(10):1408.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.021]
[6]闫晓彤,朱 婷,章晓乐,等.补肾活血方联合补佳乐对宫腔粘连大鼠YAP1/TGF-β1信号通路的影响[J].陕西中医,2022,(8):987.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.001]
　YAN Xiaotong,ZHU Ting,ZHANG Xiaole,et al.Effect of Bushen Huoxue decoction combined with Progynova on YAP1/TGF-β1 pathway in intrauterine adhesions rats[J].,2022,(9):987.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.001]
[7]张 瑾,赵虎斌,陈 琳,等.温针灸联合透药疗法治疗薄型子宫内膜临床研究[J].陕西中医,2022,(8):1106.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.029]
　ZHANG Jin,ZHAO Hubin,CHEN Lin,et al.Effect of warm needling combined with drug penetration therapy on patients with thin endometrium[J].,2022,(9):1106.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.029]
[8]王思允,汪亚琼,陈晓颖.补肾活血安胎方治疗妊娠早期绒毛膜下血肿疗效研究[J].陕西中医,2022,(10):1369.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.010]
　WANG Siyun,WANG Yaqiong,CHEN Xiaoying.Effect of Bushen Huoxue Antai prescription on subchorionic hematoma in early pregnancy[J].,2022,(9):1369.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.010]
[9]王淑平,李艳芳,孙 雪,等.茵陈蒿汤联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症疗效及Th17/Treg失衡对妊娠结局的影响[J].陕西中医,2023,(8):1074.[doi:DOI:10.3969/j.issn.1000-7369.2023.08.017]
　WANG Shuping,LI Yanfang,SUN Xue,et al.Efficacy of Yinchenhao decoction combined with ursodeoxycholic acid in the treatment of ICP and the effect of Th17/Treg imbalance on pregnancy outcome[J].,2023,(9):1074.[doi:DOI:10.3969/j.issn.1000-7369.2023.08.017]
[10]赵 欣,丁冰倩,王雪嫄,等.补肾健脾方对早期先兆流产患者阴道微生态及免疫功能的影响[J].陕西中医,2024,(3):340.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.011]
　ZHAO Xin,DING Bingqian,WANG Xueyuan,et al.Effects of Bushen Jianpi prescription on vaginal microecology and immune function in early threatened abortion[J].,2024,(9):340.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.011]

备注/Memo

备注/Memo:
基金项目:广西壮族自治区中医药管理局科研课题(GZSY23-90)
更新日期/Last Update: 2023-09-08