[1]刘晶晶,张小健,刘宏伟,等.通督益脑化痰法治疗风痰阻络型缺血性脑卒中临床研究[J].陕西中医,2023,(10):1391-1394.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.012]
　LIU Jingjing,ZHANG Xiaojian,LIU Hongwei,et al.Tongdu Yinao Huatan method in the treatment of wind-phlegm-stasis ischemic stroke[J].,2023,(10):1391-1394.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.012]
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通督益脑化痰法治疗风痰阻络型缺血性脑卒中临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年10期
页码:
1391-1394
栏目:
临床研究
出版日期:
2023-10-05

文章信息/Info

Title:
Tongdu Yinao Huatan method in the treatment of wind-phlegm-stasis ischemic stroke
作者:
刘晶晶; 张小健; 刘宏伟; 焦雪蕾; 许长敏
(北京中医医院顺义医院脑病科,北京 101300)
Author(s):
LIU Jingjing; ZHANG Xiaojian; LIU Hongwei; JIAO Xuelei; XU Changmin
(Department of Encephalopathy,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)
关键词:
缺血性脑卒中;  通督益脑化痰法;  风痰阻络型;  胰岛素样生长因子-1;  脑源性神经营养因子;  血管内皮生长因子
Keywords:
Ischemic stroke;  Tongdu Yinao Huatan method;  Wind-phlegm-stasis type;  Insulin-like growth factor-1;  Brain-derived neurotrophic factor;  Vascular endothelial growth factor
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7369.2023.10.012
文献标志码:
A
摘要:
目的:探讨通督益脑化痰法在风痰阻络型缺血性脑卒中(IS)治疗中的应用价值及对胰岛素样生长因子-1(IGF-1)、脑源性神经营养因子(BDNF)及血管内皮生长因子(VEGF)的影响。方法:随机将120例IS(风痰阻络型)患者分为接受西药常规治疗的对照组及接受西药联合通督益脑化痰法治疗的观察组,每组60例。对比两组中医临床症状、神经功能损伤、血清神经递质、IGF-1、BDNF及VEGF变化情况。结果:治疗2周后,观察组与对照组相比,头晕、半身不遂、口眼歪斜、言语謇涩、感觉减退及总评分明显降低(P<0.05)。治疗2周后,观察组与对照组相比,NIHSS评分明显降低,MMSE评分及ADL评分明显升高(P<0.05)。治疗2周后,与对照组相比,观察组5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)、BDNF及VEGF水平明显升高,IGF-1明显降低(P<0.05)。观察组的总有效率与对照组相比明显提高(P<0.05)。结论:在IS(风痰阻络型)的治疗中,通督益脑化痰法可有效提高患者的治疗效果,改善患者的IGF-1、BDNF及VEGF水平。
Abstract:
Objective:To investigate the application value of Tongdu Yinao Huatan method in the treatment of wind-phlegm-stasis type ischemic stroke and its investigate the effect on IGF-1,BDNF and VEGF.Methods:A total of 120 patients with ischemic stroke(wind-phlegm-stasis type)were randomly divided into control group receiving conventional western medicine treatment and observation group receiving traditional Chinese medicine decoction under the guidance of Tongdu Yinao Huatan method,with 60 cases in each group.Traditional Chinese medicine clinical symptoms,neurological function injury,serum neurotransmitter,IGF-1,BDNF and VEGF changes were compared between the two groups.Results:After 2 weeks of treatment,compared with the control group,the observation group showed a significant decrease in dizziness,hemiplegia,mouth and eye deviation,speech difficulty,decreased sensation,and overall score(P<0.05).After 2 weeks of treatment,compared with the control group,the NIHSS score in the observation group was significantly reduced,while the MMSE score and ADL score were significantly increased(P<0.05).After 2 weeks of treatment,compared with the control group,the levels of 5-HT,NE,DA,BDNF,and VEGF in the observation group were significantly increased,while IGF-1 was significantly reduced(P<0.05).The total effective rate of the observation group was significantly improved compared to the control group(P<0.05).Conclusion:In the treatment of ischemic stroke(wind-phlegm-stasis type),Tongdu Yinao Huatan method can effectively improve the therapeutic effect of patients,improve the levels of IGF-1,BDNF and VEGF.

参考文献/References:

[1] 刘 玥,金香兰,张 寅,等.脑卒中高危人群临床流行病学特征的中西医研究进展[J].中西医结合心脑血管病杂志,2019,17(8):1180-1183.
[2] 陈 光,付 淼.急性缺血性脑卒中患者脑血管储备功能与其急诊治疗结局相关性分析[J].陕西医学杂志,2023,52(1):53-56.
[3] 王梦祥,黑欢欢.颅内时间飞跃法磁共振血管成像技术在脑梗死患者出血性转化中应用价值的评价[J].陕西医学杂志,2022,51(4):424-428.
[4] 高天理.不同时间窗急性IS患者及不同药物在静脉溶栓治疗中的临床应用推荐:2021版《欧洲卒中组织急性IS静脉溶栓指南》解读[J].实用心脑肺血管病杂志,2021,29(7):1-8.
[5] 周啸天,骆亚莉,李佳蔚,等.补阳还五汤防治IS作用机制的研究现状[J].中国临床药理学杂志,2022,38(9):1011-1015.
[6] 张 鼎,向军军,李方存,等.温阳复元方对脑缺血再灌注损伤大鼠的治疗机制[J].陕西中医,2023,44(3):279-284.
[7] 韩 静,蒋 畅,张继州,等.从栝楼桂枝汤“异病同治”脑卒中和癫痫的网络靶标探讨其解痉作用机制[J].福建医科大学学报,2022,56(3):204-212.
[8] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性IS诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[9] 中国中西医结合学会神经科专业委员会.中国脑梗死中西医结合诊治指南(2017)[J].中国中西医结合杂志,2018,38(2):136-144.
[10] 国家食品药品监督管理总局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:134-139.
[11] 吴 凡,田立茹,刘桐伊,等.缺血性中风中医证候演变与中风复发关系研究[J].现代中西医结合杂志,2019,28(16):1715-1718,1723.
[12] 王艳华.半夏白术天麻汤加味辅助治疗缺血性脑卒中风痰瘀阻证53例临床观察[J].甘肃中医药大学学报,2020,37(4):49-52.
[13] 康 雷,赵晓东,贾冬冬,等.半夏白术天麻汤联合西药治疗颈动脉粥样硬化风痰阻络证临床研究[J].天津中医药,2020,37(9):1009-1013.
[14] 穆昭威,张晶毓,马 腾,等.半夏白术天麻汤加减联合依达拉奉治疗急性缺血性脑卒中有效性及安全性的系统评价和序贯分析[J].中西医结合心脑血管病杂志,2022,20(12):2135-2145.
[15] 官玥玥,陈正权,胡向海,等.急性缺血性中风中医证候要素及证候分布特点研究[J].中国中医急症,2022,31(10):1745-1748.
[16] 冉茂花,李 钦.半夏白术天麻汤治疗急性缺血性脑卒中的临床效果[J].深圳中西医结合杂志,2022,32(22):57-59.
[17] 王 渭,游 娟,罗 洁.半夏白术天麻汤加味治疗缺血性中风风痰阻络证疗效研究[J].陕西中医,2022,43(12):1717-1720.
[18] 孙国兵,陈 延,宋 林,等.加味半夏白术天麻汤合桃红四物汤联合西药治疗风痰阻络证中风的临床观察[J].中西医结合心脑血管病杂志,2020,18(23):3945-3949.
[19] 周抒阳,付旭阳,闫 艳,等.基于网络药理学的半夏白术天麻汤治疗脑卒中作用机制研究[J].内蒙古医科大学学报,2022,44(2):133-138.
[20] 闫梦晗,李 晓,姜月华.半夏白术天麻汤的临床应用及药理研究进展[J].中西医结合心脑血管病杂志,2020,18(14):2265-2268.
[21] 马艳春,吴文轩,胡建辉,等.当归的化学成分及药理作用研究进展[J].中医药学报,2022,50(1):111-114.
[22] 李 平,夏文广,郑婵娟,等.基于网络药理学和分子对接探讨桃仁-红花药对治疗IS潜在机制[J].世界最新医学信息文摘,2022,22(74):42-49.

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备注/Memo

备注/Memo:
基金项目:北京市科技计划课题(Z181100001718050); 北京市属医院科研培育计划项目(PZ2020021)
更新日期/Last Update: 2023-10-09