[1]刘云平,林才志,杨叶华,等.参苓白术散治疗功能性肠病伴腹泻研究进展[J].陕西中医,2023,(10):1494-封3.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.037]
 LIU Yunping,LIN Caizhi,YANG Yehua,et al.Research progress on the treatment of functional bowel diseases with diarrhea by Shenling Baizhu San[J].,2023,(10):1494-封3.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.037]
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参苓白术散治疗功能性肠病伴腹泻研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年10期
页码:
1494-封3
栏目:
综 述
出版日期:
2023-10-05

文章信息/Info

Title:
Research progress on the treatment of functional bowel diseases with diarrhea by Shenling Baizhu San
作者:
刘云平1林才志2杨叶华1吴欣尧1温丽萍1
(1.广西中医药大学研究生学院,广西 南宁530020; 2.广西中医药大学第一附属医院,广西 南宁530020)
Author(s):
LIU YunpingLIN CaizhiYANG YehuaWU XinyaoWEN Liping
(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530020,China)
关键词:
泄泻 功能性肠病 参苓白术散 腹泻型肠易激综合征 功能性腹泻
Keywords:
Diarrhea Functional bowel diseases Shenling Baizhu San Diarrhea-predominant irritable bowel syndrome Functional diarrhea
分类号:
R 574
DOI:
DOI:10.3969/j.issn.1000-7369.2023.10.037
文献标志码:
A
摘要:
功能性肠病伴腹泻是一类消化道系统常见病,其涉及多种病理机制,病情缠绵难愈,严重影响患者身心健康。目前西医以对症治疗为主,难以达及病之本,病情易反复,持久疗效有限,部分药物存在明显不良反应,因此寻求安全且疗效确切的治法仍然是当前持续关注的问题且仍最具挑战性。研究发现参苓白术散应用于腹泻型功能性肠病治疗中,屡屡奏效,且复发率、不良反应发生率更低。现就参苓白术散治疗腹泻型功能性肠病的相关研究进行综述以为腹泻型功能性肠病的有效治疗及参苓白术散的应用和进一步研究提供参考。
Abstract:
Functional bowel diseases with diarrhea is a common disease of the gastrointestinal system,which involves multiple pathological mechanisms and is persistent,seriously affecting the physical and mental health of patients.Currently,western medicine is mainly based on symptomatic treatment,which is difficult to reach the root of the disease,easy to recur,limited lasting efficacy,and some drugs have obvious adverse effects,therefore,the search for safe and effective treatments is still a continuous concern and remains the most challenging.It has been found that Shenling Baizhu San are effective in the treatment of diarrhea-predominant functional bowel diseases,and the recurrence rate and the incidence of adverse effects are much lower.Therefore,this paper reviews the research related to the treatment of diarrheal functional bowel diseases with Shenling Baizhu San in order to provide a reference for the effective treatment of diarrheal functional bowel diseases and the promotion of the application of Shenling Baizhu San and further research.

参考文献/References:

[1] Singh P,Lee HN,Rangan V,et al.Similarities in clinical and psychosocial characteristics of functional diarrhea and irritable bowel syndrome with diarrhea[J].Clin Gastroenterol Hepatol,2020,18(2):399-405.
[2] Ma C,Congly SE,Novak KL,et al.Epidemiologic burden and treatment of chronic symptomatic functional bowel disorders in the united states:A nationwide analysis[J].Gastroenterology,2021,160(1):88-98.
[3] 曹燕华,张黎黎.温肾止泻中药敷脐联合饮食管理改善腹泻型肠易激综合征患者的效果观察[J].河北医药,2022,44(23):3619-3622.
[4] Sperber AD,Bangdiwala SI,Drossman DA,et al.Worldwide prevalence and burden of functional gastrointestinal disorders,results of rome foundation global study[J].Gastroenterology,2021,160(1):99-114.
[5] Savarino E,Zingone F,Barberio B,et al.Functional bowel disorders with diarrhoea:Clinical guidelines of the united european gastroenterology and european society for neurogastroenterology and motility[J].United European Gastroenterol J,2022,10(6):556-584.
[6] 季洪赞,吴晓尉,许小兵,等.老年人功能性肠道障碍与高血压靶器官损害相关性研究[J].中国慢性病预防与控制,2007,90(4):365-366.
[7] 葛建新,印 睿,汤玉蓉,等.263例功能性肠病5年随访分析[J].中国内镜杂志,2013,19(12):1257-1262.
[8] 田 帝,王垂杰.中西医治疗功能性腹泻研究进展[J].辽宁中医药大学学报,2019,21(11):222-224.
[9] 方秀才.罗马Ⅳ功能性肠病诊断标准的修改对我国的影响[J].胃肠病学和肝病学杂志,2017,26(5):481-483.
[10] 魏 玮,尹 璐,刘 力,等.消化系统常见病功能性腹泻中医诊疗指南(基层医生版)[J].中华中医药杂志,2020,35(3):1360-1364.
[11] 曾恩锦,吕 林,王凤云,等.从“湿胜则濡泄”探讨功能性腹泻的中医治疗[J].中国中西医结合消化杂志,2020,28(2):96-98,103.
[12] 庞 佳,黄雅慧.参苓白术散加减治疗功能性腹泻45例[J].山西医药杂志,2018,47(17):2058-2059.
[13] 何海滨,王美蓉,陈龙娇,等.参苓白术散加减治疗脾胃虚弱型功能性腹泻的疗效及对肠道菌群的影响[J].实用中西医结合临床,2021,21(12):16-17.
[14] 史林林,刘 力,刘智斌,等.针药结合治疗功能性腹泻[J].中医学报,2019,34(9):1993-1996.
[15] 许继宗,李玉华,张 喆,等.体感五行音乐疗法联合参苓白术散治疗功能性腹泻疗效观察[J].现代中西医结合杂志,2012,21(35):3905-3906.
[16] 王金鑫,谢 胜,黄茂光,等.肠紧密连接在腹泻型肠易激综合征中的作用及中医药干预的研究进展[J].中国实验方剂学杂志,2023,29(2):253-259.
[17] 林欣蓉,郭绍举,李海文,等.腹泻型肠易激综合征病例证素分布及用药规律研究[J].广州中医药大学学报,2022,39(3):485-490.
[18] 赵亚刚,韩 伟,王景杰,等.精神心理因素参与功能性肠病发病机制的研究进展[J].现代消化及介入诊疗,2022,27(5):537-540.
[19] 马 岚,张正晶,刘 晗,等.难治性肠易激综合征-腹泻型诱发的相关影响因素分析[J].陕西医学杂志,2015,44(12):1691-1692.
[20] 郝孝盈,贾成文.参苓白术散加味治疗腹泻型肠易激综合征临床观察[J].陕西中医,2015,36(11):1506-1507.
[21] 赵玉洁,曹志群.参苓白术散联合匹维溴铵片治疗腹泻型肠易激综合征的临床疗效及安全性评价[J].世界中医药,2019,14(5):1278-1281.
[22] 贾小萌,陈伟健,钟 悦,等.针刺调神方联合参苓白术散治疗脾虚湿盛腹泻型肠易激综合征的临床观察[J].广州中医药大学学报,2022,39(7):1573-1577.
[23] 高春波.参苓白术散加艾灸治疗腹泻型肠易激综合征的临床观察[J].陕西中医,2016,37(8):944-945.
[24] 董 燕,梁 健,魏晓松,等.参苓白术散加减联合毫火针治疗腹泻型肠易激综合征疗效及对内脏敏感性的影响[J].中国中医急症,2023,32(4):707-709.
[25] 仇瑞莉,张小瑞,刘江波.参苓白术散治疗功能性腹泻(脾胃虚弱证)疗效及对DAO、TNF-α等炎症因子的影响[J].中华中医药学刊,2018,36(8):1957-1959.
[26] 胡 聪.参苓白术散加减治疗对老年慢性功能性腹泻的疗效及脑肠轴调控机制[J].实用医学杂志,2020,36(18):2593-2597.
[27] 秦百通,段菊花,陈正高,等.加味参苓白术散治疗腹泻型肠易激综合征的临床疗效及对脑肠肽水平的影响[J].中西医结合研究,2021,13(2):77-80.
[28] 朱创键.双歧三联活菌胶囊联合参苓白术散对腹泻型IBS患者血浆SS和NPY水平影响及疗效观察[J].中国微生态学杂志,2015,27(5):552-554,557.
[29] 李 元.基于脑肠肽探讨功能性腹泻脾虚证“脾失健运”生物学机制及中药疗效机制[D].北京:北京中医药大学,2018.
[30] 李 晶,王垂杰,李玉锋,等.参苓白术颗粒对功能性腹泻大鼠结肠黏膜紧密连接蛋白表达的作用[J].中国实验方剂学杂志,2016,22(12):102-107.
[31] 李小雅,吴月滢,李玉卿,等.和调健脾方对修复功能性腹泻大鼠肠黏膜损伤的相关作用机制研究[J].现代中药研究与实践,2020,34(3):23-26.
[32] 张 琦,廖梦婷,王 艳,等.基于AQP3、AQP8探讨参苓白术散治疗功能性腹泻脾虚证大鼠模型的机制研究[J].世界中西医结合杂志,2021,16(7):1237-1243.
[33] 马金鑫.参苓白术散对功能性腹泻脾虚证模型大鼠结肠上皮转运蛋白的影响[D].北京:中国中医科学院,2020.
[34] Xiao Y,Zhang K,Zhu SY,et al.Shenling Baizhu powder ameliorates pi-deficiency-induced functional diarrhea in rats[J].Chin J Integr Med,2021,27(3):206-211.
[35] 于洁琼,彭思远,凌茜文,等.参苓白术散对伴焦虑腹泻型肠易激综合征模型小鼠的改善作用及机制[J].中国药房,2021,32(3):314-319.
[36] 申中美.参苓白术散对腹泻型肠易激综合征的临床疗效系统评价及作用机制研究[D].南京:南京中医药大学,2020.
[37] 廖美华,张 涛,赖冬萍,等.基于网络药理学及分子对接探讨参苓白术散治疗腹泻型肠易激综合征的作用机制[J].海南医学院学报,2022,28(6):443-452.
[38] Meng M,Bai C,Wan B,et al.A Network pharmacology-based study on irritable bowel syndrome prevention and treatment utilizing shenling baizhu powder[J].Biomed Res Int,2021,23:1-14.

备注/Memo

备注/Memo:
基金项目: 国家自然科学基金资助项目(82060834)
更新日期/Last Update: 2023-10-09