[1]黄永红,陆江涛,黄建国,等.活血接骨汤联合复方骨肽对跟骨骨折术后患者血液流变学、骨代谢因子的影响[J].陕西中医,2023,(11):1558-1561.[doi:DOI:10.3969/j.issn.1000-7369.2023.11.014]
　HUANG Yonghong,LU Jiangtao,HUANG Jianguo,et al.Influence of Huoxue Jiegu decoction combined with compound bone peptide on hemorheology and bone metabolic factors of patients after calcaneal fracture[J].,2023,(11):1558-1561.[doi:DOI:10.3969/j.issn.1000-7369.2023.11.014]
点击复制

活血接骨汤联合复方骨肽对跟骨骨折术后患者血液流变学、骨代谢因子的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年11期
页码:
1558-1561
栏目:
临床研究
出版日期:
2023-11-05

文章信息/Info

Title:
Influence of Huoxue Jiegu decoction combined with compound bone peptide on hemorheology and bone metabolic factors of patients after calcaneal fracture
作者:
黄永红; 陆江涛; 黄建国; 胡春祥; 王自耿
(三亚市中医院骨四科,海南 三亚 572000)
Author(s):
HUANG Yonghong; LU Jiangtao; HUANG Jianguo; HU Chunxiang; WANG Zigeng
(Four Department of Bone,Sanya Traditional Chinese Medicine Hospital,Sanya 572000,China)
关键词:
跟骨骨折;  活血接骨汤;  复方骨肽注射液;  血液流变学;  血清因子;  骨代谢;  不良反应
Keywords:
Calcaneal fracture;  Huoxue Jiegu decoction;  Compound osteopeptide injection;  Hemorheology;  Serum factor;  Bone metabolism;  Adverse reaction
分类号:
R 683
DOI:
DOI:10.3969/j.issn.1000-7369.2023.11.014
文献标志码:
A
摘要:
目的:观察活血接骨汤联合复方骨肽对跟骨骨折术后患者血液流变学、骨代谢因子的影响。方法:选取108例跟骨骨折患者,采用信封法随机分为两组。对照组(n=52)给予复方骨肽注射液治疗,联合组(n=56)在对照组基础上给予活血接骨汤治疗。比较两组首次皮纹出现时间、住院时间、张力性水疱发生率、血液流变学、血清相关因子、中医证候积分、不良反应发生率。结果:联合组首次皮纹出现时间、住院时间短于对照组,张力性水疱发生率低于对照组,差异有统计学意义(均P<0.05)。两组治疗1、3、5 d后疼痛评分均较治疗前降低,且联合组低于对照组,差异有统计学意义(均P<0.05)。治疗1、3、5 d后肿胀消除率高于对照组(P<0.05)。治疗后两组中医证候积分、血液流变学指标、缺氧诱导因子-α、肿瘤坏死因子-α低于治疗前,且联合组低于对照组,差异有统计学意义(均P<0.05)。治疗后两组血清骨保护素、胰岛素样生长因子、Ⅰ型前胶原羧基端肽、骨形态发生蛋白高于治疗前,且联合组高于对照组,差异有统计学意义(均P<0.05)。联合组不良反应率与对照组比较,差异无统计学意义(P>0.05)。结论:活血接骨汤联合复方骨肽注射液能促进跟骨骨折患者缓解疼痛、消退肿胀,改善血液流变学、骨代谢。
Abstract:
Objective:To observe effects of Huoxue Jiegu decoction combined with compound bone peptide on hemorheology and bone metabolic factors of patients after calcaneal fracture.Methods:108 patients with calcaneal fracture were randomly divided into two groups by envelope method.The control group(n=52)were treated with compound bone peptide injection,and combined group(n=56)treated with Huoxue Jiegu decoction on the basis of the control group.The time of first appearance of skin marks,length of hospital stay,incidence of tension blister,hemorheology,serum related factors,TCM syndrome scores,incidence of adverse reactions between the two groups were compared.Results:The time of appearance of the first skin line,hospital stay,incidence of tension blistersin the combined group were shorter than those in the control group,difference statistically significant(all P<0.05).The pain scores of the two groups after 1,3 and 5 days of treatment were lower than those before treatment,and the combined group were lower than those in the control group,difference statistically significant(all P<0.05).The reduction rate of swelling after 1,3 and 5 days of treatment were higher than those in the control group,difference statistically significant(all P<0.05).After treatment,TCM syndrome score,hemorheology index,hypoxia-induced-factor-α and tumor necrosis factor-α were lower in the two groups than before treatment,and the combined group were lower than those in the control group,difference statistically significant(all P<0.05).After treatment,serum osteophorin,insulin-like growth factor,carboxy-terminal peptide of type Ⅰ procollagen and bone morphogenetic protein in two groups were higher than before treatment,and the combined group were higher than those in the control group,difference statistically significant(all P<0.05).The adverse reaction rate of combination group was compared with that in the control group,difference not statistically significant(P>0.05).Conclusion:The treatment of calcaneal fracture with Huoxue Jiegu decoction combined with compound osteopeptide injection can promote the regression of pain and swelling,improve hemorheology and bone metabolism.

参考文献/References:

[1] 刘泽民,吕 欣,张 经,等.两种手术方式治疗SandersⅡ与Ⅲ型跟骨骨折疗效的Meta分析[J].中国骨与关节杂志,2021,10(5):391-400.
[2] 吕红芝,秦士吉,李文静,等.跟骨骨折术后功能恢复的相关因素分析[J].中华创伤骨科杂志,2022,24(5):402-408.
[3] 陈延武,阴小龙,董 博,等.中药溻渍疗法治疗早期跟骨骨折临床疗效观察[J].陕西中医,2020,41(11):1619-1622.
[4] 中华医学会.临床诊疗指南?骨科分册[M].北京:人民卫生出版社,2009:33.
[5] 国家中医药管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:339-342.
[6] 孙 兵,车晓明.视觉模拟评分法[J].中华神经外科杂志,2012,28(6):645.
[7] Raja SN,Carr DB,Cohen M,et al.The revised international association for the study of pain definition of pain:Concepts challenges and compromises[J].Pain,2020,161(9):1976-1982.
[8] 刘旺鑫,徐新宇,王一帆,等.中医药治疗骨折术后肿痛研究进展[J].中国中医药信息杂志,2020,27(4):141-144.
[9] 罗换新.促愈活血方辅助急诊外侧入路手术治疗SandersⅡ、Ⅲ型跟骨骨折效果及可能机制[J].安徽医药,2022,26(6):1202-1205.
[10] 吴鹏飞,李 森,徐子卿.续骨强筋方辅助经皮微创内固定术对四肢骨折患者血清碱性磷酸酶、骨保护素表达及骨折愈合的影响[J].世界中西医结合杂志,2022,17(7):1355-1359.
[11] 张昊东,窦红莉,叶梦怡.没药药性与功效应用的本草文献研究[J].山西中医,2020,36(3):49-50,57.
[12] 赵 敏,刁 丽,王淑梅,等.红花黄色素氯化钠注射液联合外敷冰黄散对四肢闭合骨折患者术后肿胀疼痛、炎症反应及凝血功能的影响[J].现代中西医结合杂志,2021,30(10):1083-1086.
[13] 陈章美,夏中尚,邓家刚,等.基于数据挖掘中药复方治疗下肢骨折用药规律探析[J].辽宁中医药大学学报,2021,23(6):191-195.
[14] 邓成杰,刘 爽,徐晓云,等.苏木化学成分及药理作用的研究进展[J].中国现代中药,2020,22(5):810-826.
[15] Allegra PR,Rivera S,Desai SS,et al.Intra-articular calcaneus fractures:Current concepts review[J].Foot Ankle Orthop,2020,5(3):1-11.
[16] 王 汉,黄友华,符林雄,等.血清β-CTX、Cathe K、OPG对老年OPF患者术后骨折再发的预测价值[J].中国骨质疏松杂志,2022,28(2):205-209.
[17] Halm JA,Beerekamp MS,Muinck RJ,et al.Intraoperative effect of 2D vs 3D fluoroscopy on quality of reduction and patient-related outcome in calcaneal fracture surgery[J].Foot and Ankle International,2020,41(8):954-963.
[18] 胡松峰,许伟攀,王立刚,等.理气四物汤通过调控骨形态发生蛋白-2信号通路加速骨折愈合的研究[J].中华中医药杂志,2021,36(11):6738-6742.
[19] 李泽新,张贝贝.血清缺氧诱导因子-1α、前列腺素E2水平与动脉瘤性蛛网膜下腔出血关系及对脑血管痉挛的预测价值[J].陕西医学杂志,2023,52(2):141-144,191.
[20] 杨萌国,樊文勃,张 磊.血清IL-6、TNF-α水平对骨折内固定术后感染的预测价值[J].贵州医药,2022,46(7):1138-1139.

备注/Memo

备注/Memo:
基金项目:海南省卫生计生行业科研项目(19A200113)
更新日期/Last Update: 2023-11-09