[1]王 萍,章巧琪,倪家庆,等.补虚祛风方治疗慢性肾衰竭脾肾阳虚证疗效研究[J].陕西中医,2023,(11):1566-1569.[doi:DOI:10.3969/j.issn.1000-7369.2023.11.016]
　WANG Ping,ZHANG Qiaoqi,NI Jiaqing,et al.Curative effect study on Buxu Qufeng decoction in treatment of chronic renal failure of Pishen Yangxu syndrome[J].,2023,(11):1566-1569.[doi:DOI:10.3969/j.issn.1000-7369.2023.11.016]
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补虚祛风方治疗慢性肾衰竭脾肾阳虚证疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年11期
页码:
1566-1569
栏目:
临床研究
出版日期:
2023-11-05

文章信息/Info

Title:
Curative effect study on Buxu Qufeng decoction in treatment of chronic renal failure of Pishen Yangxu syndrome
作者:
王 萍; 章巧琪; 倪家庆; 韩文可; 杨柳易; 姜 林; 米秀华
(上海市宝山区中西医结合医院肾内科,上海 201999)
Author(s):
WANG Ping; ZHANG Qiaoqi; NI Jiaqing; HAN Wenke; YANG Liuyi; JIANG Lin; MI Xiuhua
(Department of Nephrology,Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 201999,China)
关键词:
慢性肾脏疾病;  慢性肾衰竭;  补虚祛风方;  脾肾阳虚证;  肾功能;  细胞因子;  炎症反应
Keywords:
Chronic kidney disease;  Chronic renal failure;  Buxu Qufeng decoction;  Pishen Yangxu syndrome;  Renal function;  Cytokines;  Inflammatory response
分类号:
R 692.5
DOI:
DOI:10.3969/j.issn.1000-7369.2023.11.016
文献标志码:
A
摘要:
目的:观察补虚祛风方治疗慢性肾脏疾病(CKD)3期慢性肾衰竭(CRF)脾肾阳虚证的疗效。方法:选取208例CKD3期CRF脾肾阳虚证患者为观察对象,采用随机数字表法将其分为试验组、对照组。试验组采用补虚祛风方联合西医治疗,对照组采用西医常规治疗。比较两组治疗后的临床疗效、中医证候评分、血尿酸(BUA)、血尿素氮(BUN)、血肌酐(Scr)、肾小球滤过率(GFR)、转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)、高敏-C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、不良反应发生情况。结果:治疗后,试验组临床总有效率90.38%高于对照组77.88%(P<0.05)。治疗后,两组主症、次症评分、证候总评分、BUA、BUN、Scr、TGF-β1、IL-6、hs-CRP、TNF-α低于治疗前,GFR、VEGF、MMP-9高于治疗前,差异有统计学意义(均P<0.05)。治疗后,上述指标组间比较,差异有统计学意义(均P<0.05)。治疗期间,所有患者三大常规、心电图、肝功能等均未见明显异常。结论:补虚祛风方治疗CKD3期CRF脾肾阳虚证疗效较好,可有效改善患者中医证候、肾功能,利于减轻微炎症反应,且用药较安全。
Abstract:
Objective:To observe efficacy of Buxu Qufeng decoction in treatment of stage 3 chronic kidney disease(CKD)with chronic renal failure(CRF)of Pishen Yangxu syndrome.Methods:208 patients with stage 3 CKD and CRF were selected as observation subjects,divided into experimental group and control group by the random number table method.The experimental group were treated with Buxu Qufeng prescription combined with western medicine,while the control group treated with conventional western medicine.Clinical efficacy,scores of TCM syndromes,BUA,BUN,Scr,GFR,TGF-β1,VEGF,MMP-9,IL-6,hs-CRP,TNF-α and occurrence of adverse reactions were compared between the two groups after treatment.Results:After treatment,the total clinical effective rate of the experimental group 90.38% was significantly higher than that in the control group 77.88%(P<0.05).The scores of primary symptoms and secondary symptoms,total score of symptoms and levels of BUA,BUN,Scr,TGF-β1,IL-6,hs-CRP and TNF-α of the two groups were significantly decreased,while the levels of GFR,VEGF and MMP-9 were significantly enhanced,difference statistically significant(all P<0.05).The above indicator of the experimental group were significantly different from those in the control group,difference statistically significant(all P<0.05).During treatment,there were no obvious abnormalities in the three routines,electrocardiogram and liver function among all patients.Conclusion:Buxu Qufeng decoction has significant efficacy in the treatment of stage 3 CKD with CRF of Pishen Yangxu syndrome.It can effectively improve TCM syndromes and renal function of patients.It is conducive to relieving microinflammatory response,with medication safety.

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备注/Memo

备注/Memo:
基金项目:上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2020)-FWTX-7001]
更新日期/Last Update: 2023-11-09