[1]舒囿淞,李 洁,王赛华,等.降气达郁汤联合艾司西酞普兰治疗卒中后焦虑抑郁共病状态临床研究[J].陕西中医,2023,(12):1709-1712.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.009]
　SHU Yousong,LI Jie,WANG Saihua,et al.Effect of Jiangqi Dayu decoction combined with escitalopram on post-stroke comorbid anxiety and depression[J].,2023,(12):1709-1712.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.009]
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降气达郁汤联合艾司西酞普兰治疗卒中后焦虑抑郁共病状态临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1709-1712
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Effect of Jiangqi Dayu decoction combined with escitalopram on post-stroke comorbid anxiety and depression
作者:
舒囿淞; 李 洁; 王赛华; 何 治
(武汉市第一医院康复科,湖北 武汉 430010)
Author(s):
SHU Yousong; LI Jie; WANG Saihua; HE Zhi
(Department of Rehabilitation,the First Hospital of Wuhan,Wuhan 430010,China)
关键词:
脑卒中;  焦虑抑郁共病状态;  降气达郁汤;  艾司西酞普兰;  睡眠结构;  生活质量
Keywords:
Stroke;  Anxiety and depression;  Jiangqi Dayu decoction;  Escitalopram;  Sleep structure
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.009
文献标志码:
A
摘要:
目的:探讨降气达郁汤联合艾司西酞普兰治疗卒中后焦虑抑郁共病状态(PSCAD)的临床效果。方法:选取PSCAD患者201例,随机分为对照组100例与观察组101例,对照组应用艾司西酞普兰治疗,观察组采用降气达郁汤联合艾司西酞普兰治疗,治疗2个月后,比较两组临床疗效、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、去甲肾上腺素(NE)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、5-羟色胺(5-HT)、世界卫生组织生存质量测定简表(WHOQOL-BREF)评分、睡眠结构[总卧床时间(TIB)、实际睡眠时间(AST)、总睡眠时间(TST)]、不良反应。结果:观察组临床治疗总有效率较对照组显著升高(P<0.05); 治疗后,两组NE、5-HT、生活质量各项评分、TST、TIB、AST较治疗前显著升高,TNF-α、IL-6水平较治疗前显著降低(均P<0.05); 观察组NE、5-HT、生活质量各项评分、TST、TIB、AST高于对照组,TNF-α、IL-6水平低于对照组(均P<0.05); 治疗后2周、1个月、2个月时,观察组HAMA、HAMD评分低于对照组(均P<0.05); 用药过程中两组患者生命体征均平稳,未见肾、心、肝等功能损害或严重并发症。结论:降气达郁汤联合艾司西酞普兰治疗卒中后焦虑抑郁共病状态的临床效果较好,可减轻焦虑、抑郁程度,提高NE、5-HT水平及降低炎性因子水平,改善生活质量与睡眠结构。
Abstract:
Objective:To explore the clinical effect of Jiangqi Dayu decoction combined with escitalopram on post-stroke comorbid anxiety and depression(PSCAD).Methods:201 PSCAD patients were randomly divided into a control group of 100 cases and an observation group of 101 cases.The control group was treated with escitalopram,while the observation group was treated with Jiangqi Dayu decoction combined with escitalopram.After two months of treatment,the clinical efficacy,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score,norepinephrine(NE),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α),5-hydroxytryptamine(5-HT),World Health Organization Quality of Life Brief(WHOQOL-BREF)score,sleep structure [total bed rest time(TIB),actual sleep time(AST),total sleep time(TST)],adverse reactions were compared between two groups.Results:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,NE,5-HT,quality of life scores,TST,TIB and AST in both groups were significantly increased,while TNF-α and IL-6 levels were significantly decreased compared with those before treatment(all P<0.05).NE,5-HT,quality of life scores,TST,TIB and AST in observation group were higher than those in control group,while TNF-α and IL-6 levels were lower than those in control group(all P<0.05).At two weeks,one month and two months after treatment,HAMA and HAMD scores in the observation group were lower than those in the control group(all P<0.05).The vital signs of both groups were stable,and no functional damage or serious complications of kidney,heart and liver were observed.Conclusion:Jiangqi Dayu decoction combined with escitalopram has a good clinical effect on post-stroke comorbid anxiety and depression,which can reduce the degree of anxiety and depression,increase the level of NE,5-HT and reduce the level of inflammatory factors,and improve the quality of life and sleep structure.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82073824)
更新日期/Last Update: 2023-12-08