[1]孙 霞,杨宏杰,张 曾,等.疏肝解毒法治疗桥本甲状腺炎甲状腺功能减退期临床研究[J].陕西中医,2023,(12):1726-1729,1734.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.013]
　SUN Xia,YANG Hongjie,ZHANG Zeng,et al.Clinical curative effect of soothing liver and detoxification method on patients with hashimoto's thyroiditis hypothyroidism[J].,2023,(12):1726-1729,1734.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.013]
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疏肝解毒法治疗桥本甲状腺炎甲状腺功能减退期临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1726-1729,1734
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Clinical curative effect of soothing liver and detoxification method on patients with hashimoto's thyroiditis hypothyroidism
作者:
孙 霞; 杨宏杰; 张 曾; 王之莹; 郑 敏; 何燕铭
(上海中医药大学附属岳阳中西医结合医院内分泌科,上海 200437)
Author(s):
SUN Xia; YANG Hongjie; ZHANG Zeng; WANG Zhiying; ZHENG Min; HE Yanming
(Endocrinology Department,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
关键词:
桥本甲状腺炎;  甲状腺功能减退;  疏肝解毒法;  Toll样受体;  甲状腺抗体
Keywords:
Hashimoto's thyroiditis;  Hypothyroidism;  Soothing liver and detoxification method;  Toll receptor;  Thyroid antibodies
分类号:
R 581
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.013
文献标志码:
A
摘要:
目的:研究疏肝解毒法治疗桥本甲状腺炎甲状腺功能减退期患者临床疗效及对Toll样受体2(TLR2)及Toll样受体4(TLR4)的影响。方法:选取桥本甲状腺炎甲状腺功能减退期患者80例,随机将患者分为研究组、对照组,每组各40例。对照组给予常规治疗,研究组在对照组的基础上给予疏肝解毒法治疗,治疗3个月。比较两组治疗后的中医症候评分,临床症状评分、血清学指标、甲状腺B超以及安全性指标。结果:治疗后,两组中医症候积分、临床症状积分较治疗前显著降低,且研究组低于对照组(均P<0.05)。治疗后两组血清促甲状腺素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)显著下降,游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)显著上升(均P<0.05)。治疗后,研究组TSH、TPOAb及TGAb水平显著低于对照组,研究组FT3、FT4水平显著高于对照组(均P<0.05)。两组治疗前血清TLR2、TLR4水平比较差异无统计学意义(均P>0.05)。治疗后两组血清TLR2、TLR4水平显著下降,且研究组血清TLR2、TLR4水平低于治疗组(均P<0.05)。与治疗前比较,两组治疗后甲状腺左、右叶及峡部厚度比较差异无统计学意义(均P>0.05); 治疗后两组甲状腺左、右叶及峡部厚度比较差异无统计学意义(均P>0.05)。治疗后研究组总有效率为86.49%,高于对照组的64.86%(P<0.05)。两组未出现严重不良反应。结论:疏肝解毒法治疗桥本甲状腺炎甲状腺功能减退期患者具有显著疗效,可显著降低患者中医症候评分及临床症状评分,并且改善甲状腺功能,降低甲状腺抗体水平,降低TLR2及TLR4水平。
Abstract:
Objective:This study aims to investigate the clinical efficacy of soothing liver and detoxification method on patients with hashimoto's thyroiditis in the hypothyroid stage,as well as its effect on toll-like receptor 2(TLR2)and toll-like receptor 4(TLR4).Methods:Eighty patients with hashimoto's thyroiditis and hypothyroidism were randomly divided into study group and control group,with 40 cases in each group.The control group was given conventional treatment,and the study group was given soothing liver and detoxification method on the basis of the control group for three months.The TCM symptom score,clinical symptom score,serological index,thyroid B-ultrasonography and safety index were compared between the two groups after treatment.Results:After treatment,the scores of TCM symptoms and clinical symptoms in two groups were significantly lower than before treatment,and the study group was lower than the control group(all P<0.05).After treatment,serum thyrotropin(TSH),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)were significantly decreased,and free triiodothyronine(FT3)and free thyroxine(FT4)were significantly increased in both groups(all P<0.05).After treatment,the levels of TSH,TPOAb and TGAb in the study group were significantly lower than those in the control group,while the levels of FT3 and FT4 in the study group were significantly higher than those in the control group(all P<0.05).There was no significant difference in serum TLR2 and TLR4 levels between the two groups before treatment(all P<0.05).After treatment,serum TLR2 and TLR4 levels of the two groups were significantly decreased,and the serum TLR2 and TLR4 levels of the study group were lower than those of the treatment group(all P<0.05).Compared with before treatment,there was no significant difference in the thickness of left,right lobe and isthmus between the two groups after treatment(all P>0.05).There was no significant difference in the thickness of left,right lobe and isthmus between the two groups after treatment(all P>0.05).The total effective rate of the study group was 86.49%,which was higher than that of the control group(64.86%)(P<0.05).There were no serious adverse reactions in the two groups.Conclusion:The treatment of hashimoto's thyroiditis patients with hypothyroidism by soothing liver and detoxification has a significant effect,which can reduce the scores of TCM symptoms and clinical symptoms,improve thyroid function,reduce thyroid antibody levels,and reduce TLR2 and TLR4 levels.

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备注/Memo

备注/Memo:
基金项目:上海市科学技术委员会科技支撑项目(12401904800)
更新日期/Last Update: 2023-12-08