[1]顾旭华,陈 颖,张海涛.健脾补肺汤联合阿昔洛韦注射液治疗小儿呼吸道EB病毒感染疗效研究[J].陕西中医,2023,(12):1730-1734.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.014]
　GU Xuhua,CHEN Ying,ZHANG Haitao.Efficacy of Jianpi Bufei decoction combined with acyclovir injection in the treatment of respiratory tract EB virus infection in children[J].,2023,(12):1730-1734.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.014]
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健脾补肺汤联合阿昔洛韦注射液治疗小儿呼吸道EB病毒感染疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1730-1734
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Efficacy of Jianpi Bufei decoction combined with acyclovir injection in the treatment of respiratory tract EB virus infection in children
作者:
顾旭华; 陈 颖; 张海涛
(苏州市中西医结合医院儿科,江苏 苏州 215101)
Author(s):
GU Xuhua; CHEN Ying; ZHANG Haitao
(Department of Pediatrics,Suzhou Hospital of Integrative Medicine,Suzhou 215101,China)
关键词:
EB病毒;  健脾补肺汤;  阿昔洛韦;  淋巴细胞;  免疫功能
Keywords:
EB virus;  Jianpi Bufei decoction;  Acyclovir;  Lymphocyte;  Immune function
分类号:
R 725.6
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.014
文献标志码:
A
摘要:
目的:观察健脾补肺汤联合阿昔洛韦注射液治疗小儿呼吸道Epstein-Barr病毒(EBV)感染疗效。方法:选取110例呼吸道EBV感染患儿,遵循随机数字表法将患儿分为西医组和结合组,每组55例。比较两组疗效、中医症状积分、体温消退时间、淋巴结肿大恢复时间、咽痛时间、咽充血持续时间、淋巴细胞亚类及免疫球蛋白改善情况。比较两组EB DNA转阴例数、EBV-CA-IgM转阴例数、EBV-NA-IgG转阳例数和不良反应发生情况。结果:结合组总有效率显著高于西医组(P<0.05)。治疗后,两组腹胀便溏、咳嗽纳差、食欲不振、痰多色白评分降低,且结合组显著低于西医组(均P<0.05)。结合组体温消退、淋巴结肿大恢复时间、咽痛时间及咽充血持续时间显著低于西医组(均P<0.05)。治疗后,两组CD3+、CD8+水平降低,CD4+、B细胞及NK细胞百分比升高(均P<0.05); 且结合组上述指标与西医组比较差异具有统计学意义(均P<0.05)。治疗后,两组IgA、IgG、IgM、IgE水平降低,且结合组显著低于西医组(均P<0.05)。随访4周,结合组EB DNA转阴例数、EBV-CA-IgM转阴例数显著高于西医组(均P<0.05),两组间EBV-NA-IgG转阳例数比较差异无统计学意义(P>0.05)。两组间不良反应发生情况比较差异无统计学意义(P>0.05)。结论:健脾补肺汤联合阿昔洛韦注射液治疗小儿呼吸道EBV疗效确切,能有效改善患儿临床症状,增强患儿机体免疫功能。
Abstract:
Objective:To observe the efficacy of Jianpi Bufei decoction combined with acyclovir injection in the treatment of respiratory tract Epstein-Barr virus(EBV)infection in children.Methods:110 children with respiratory tract EBV infection were selected and divided into western medicine group and combined group according to the random number table method,55 cases in each group.The efficacy,TCM symptoms scores,body temperature subsidence time,lymph node enlargement recovery time,pharyngeal pain time,pharyngeal congestion duration,lymphocyte subsets and immunoglobulin improvement were compared between the two groups.The number of EB DNA negative conversion cases,the number of EBV-CA-IgM negative conversion cases,the number of EBV-NA-IgG positive conversion cases and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate in combined group was significantly higher than that in western medicine group(P<0.05).After treatment,the scores of abdominal distension and loose stool,cough and poor appetite,loss of appetite and excessive and white sputum were decreased in both groups,and the scores in combined group were significantly lower than those in western medicine group(all P<0.05).The body temperature subsidence time,lymph node enlargement recovery time,pharyngeal pain time and pharyngeal congestion duration were significantly shorter in combined group than those in western medicine group(P<0.05).After treatment,the CD3+ and CD8+ in both groups were reduced,while the CD4+,B cell and NK cell were enhanced(all P<0.05).And the differences in the above indicators between combined group and western medicine group were statistically significant(all P<0.05).After treatment,the levels of IgA,IgG,IgM and IgE were declined in both groups,and the levels in combined group were significantly lower compared with those in western medicine group(all P<0.05).After 4 weeks of follow-up,the number of cases with EB DNA negative conversion and the number of cases with EBV-CA-IgM negative conversion in combined group were significantly more than those in western medicine group(all P<0.05),but there was no statistical significance in the number of cases with EBV-NA-IgG positive conversion between the two groups(P>0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion:Jianpi Bufei decoction combined with acyclovir injection has an exact efficacy in the treatment of respiratory tract EBV infection in children,and it can effectively improve the clinical symptoms,enhance immune function of children.

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备注/Memo

备注/Memo:
基金项目:江苏省教育厅科研项目(13KJB320014); 江苏省苏州市中西医结合医院科技项目(YJ2022004)
更新日期/Last Update: 2023-12-08