[1]王 萍,张学磊,余 航,等.黄芪桂枝五物汤对肘管综合征患者肘管扩大成形术后尺神经运动传导速度和上肢功能的影响[J].陕西中医,2023,(12):1745-1748.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.017]
　WANG Ping,ZHANG Xuelei,YU Hang,et al.Effects of Huangqi Guizhi Wuwu decoction on ulnar nerve motor conduction velocity,upper limb function in patients with cubital tunnel syndrome after extended cubital tunnel plasty[J].,2023,(12):1745-1748.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.017]
点击复制

黄芪桂枝五物汤对肘管综合征患者肘管扩大成形术后尺神经运动传导速度和上肢功能的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年12期
页码:
1745-1748
栏目:
临床研究
出版日期:
2023-12-05

文章信息/Info

Title:
Effects of Huangqi Guizhi Wuwu decoction on ulnar nerve motor conduction velocity,upper limb function in patients with cubital tunnel syndrome after extended cubital tunnel plasty
作者:
王 萍; 张学磊; 余 航; 金燕燕; 宿晓雷; 陈广先; 尹红玉
(河北省沧州中西医结合医院骨科,河北 沧州 061001)
Author(s):
WANG Ping; ZHANG Xuelei; YU Hang; JIN Yanyan; SU Xiaolei; CHEN Guangxian; YIN Hongyu
(Department of Orthopedics,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China)
关键词:
肘管综合征;  黄芪桂枝五物汤;  尺神经运动传导速度;  上肢功能;  白介素-1;  肿瘤坏死因子-α;  神经生长因子
Keywords:
Cubital tunnel syndrome;  Huangqi Guizhi Wuwu decoction;  Ulnar nerve motor conduction velocity;  Upper limb function;  Interleukin-1;  Tumor necrosis factor-α;  Nerve growth factor
分类号:
R 741
DOI:
DOI:10.3969/j.issn.1000-7369.2023.12.017
文献标志码:
A
摘要:
目的:研究黄芪桂枝五物汤对肘管综合征患者肘管扩大成形术后尺神经运动传导速度、上肢功能以及血清白介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)和神经生长因子(NGF)的影响。方法:选择行肘管扩大成形术治疗的肘管综合征患者80例为研究对象,随机分为对照组和观察组,每组40例,对照组采用甲钴胺片治疗,观察组给予黄芪桂枝五物汤加甲钴胺片治疗。治疗3个月后,比较两组疗效、尺神经运动传导速度、上肢功能优良率以及血清白介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、神经生长因子(NGF)、谷丙转氨酶(ALT)、尿素氮(BUN)及肌酐(Cr)水平。结果:观察组总有效率及上肢功能恢复优良率高于对照组,尺神经运动传导速度快于对照组,血清IL-1、TNF-α、NGF水平明显低于对照组(均P<0.05)。治疗前后两组ALT、BUN及Cr水平比较差异无统计学意义(均P>0.05)。结论:黄芪桂枝五物汤能够提升肘管综合征患者术后尺神经运动传导速度,改善上肢功能,降低血清IL-1、TNF-α、NGF水平。
Abstract:
Objective:To study the effects of Huangqi Guizhi Wuwu decoction on ulnar nerve motor conduction velocity,upper limb function,serum IL-1,TNF-α and NGF in patients with cubital tunnel syndrome after extended cubital tunnel plasty.Methods:80 patients with cubital tunnel syndrome were randomly divided into control group and observation group,40 cases in each group.The control group was treated with mecobalamin tablets,and the observation group was given Huangqi Guizhi Wuwu decoction combined mecobalamin tablets.After three months of treatment,the efficacy,ulnar nerve motor conduction velocity,superior and good rate of upper limb function and serum levels of IL-1,TNF-α,NGF,ALT,BUN and Cr were compared between the two groups.Results:The total effective rate and superior and good rate of upper limb function in observation group were higher than those in control group,the ulnar nerve motor conduction velocity was faster than that in control group,and serum levels of IL-1,TNF-α and NGF were significantly lower compared with those in control group(all P<0.05).There were no significant differences in ALT,BUN and Cr levels between the two groups before and after treatment(all P>0.05).Conclusion:Huangqi Guizhi Wuwu decoction can enhance the ulnar nerve motor conduction velocity,improve the upper limb function and reduce the levels of serum IL-1,TNF-α and NGF in patients with cubital tunnel syndrome after surgery.

参考文献/References:

[1] Baron A,Strohl A.Severe cubital tunnel syndrome:Considerations for nerve transfer surgery[J].Curr Rev Musculoskelet Med,2020,13(6):708-716.
[2] Nakashian MN,Ireland D,Kane PM.Cubital tunnel syndrome:Current concepts[J].Curr Rev Musculoskelet Med,2020,13(4):520-524.
[3] 孙守勇,王海峰,梁旭东.肘管扩大成形术治疗肘关节炎性肘管综合征[J].中国矫形外科杂志,2018,26(15):1431-1432.
[4] 黄熠东,常文凯.肘管综合征的病因诊断及治疗进展[J].实用骨科杂志,2018,24(4):342-345.
[5] Li M,Li Z,Ma X,et al.Huangqi Guizhi Wuwu decoction can prevent and treat oxaliplatin-induced neuropathic pain by TNF-α/IL-1β/IL-6/MAPK/NF-κB pathway[J].Aging(Albany NY),2022,14(12):5013-5022.
[6] 时文才,聂晨旭,胡晓龙,等.黄芪桂枝五物汤合血府逐瘀汤联合针灸治疗早期强直性脊柱炎临床研究[J].陕西中医,2020,41(3):315-317,337.
[7] 和梦珂,刘传波,胡 霞,等.黄芪桂枝五物汤加减治疗化疗手足综合征的延伸[J].中华中医药杂志,2019,34(4):1318-1321.
[8] 王澎寰.手外科学[M].3版.北京:人民卫生出版社,2011:289-290.
[9] 张宪男,顾 宇,张 梁,等.尺神经松解前置合并示指外展功能重建治疗重度肘管综合征20例[J].中国中医骨伤科杂志,2022,30(5):73-76.
[10] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:201-202.
[11] 周俊明,劳 杰,王 涛.上肢手功能康复手册[M].北京:世界图书出版公司,2017:358-359.
[12] 黄晓琳,燕铁斌.康复医学[M].6版.北京:人民卫生出版社,2018:589-590.
[13] 国家中医药管理局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:233-237.
[14] 郭文燕,李燕林.从虚实邪正辨治痹证痿证验案三则[J].环球中医药,2021,14(8):1514-1516.
[15] 马增斌,邸学士,袁巧妹,等.基于网络药理学探讨黄芪桂枝五物汤治疗颈椎病的作用机制[J].中国中医基础医学杂志,2022,28(6):969-974.
[16] 陶 根,嵇 嫒.黄芪桂枝五物汤联合温针灸治疗腕管综合征60例[J].中国中医骨伤科杂志,2019,27(3):63-65.
[17] 王 宁,张艳盛,王梦梦.脑苷肌肽对有机磷中毒性迟发性神经病变大鼠学习记忆能力及血浆钙激活的中性蛋白酶、神经疾病靶标酯酶影响研究[J].陕西医学杂志,2018,47(2):143-146.
[18] 杨秦予,周美宁.甲钴胺与维生素B12治疗早期脊髓亚急性联合变性临床研究[J].陕西医学杂志,2018,47(7):920-922,926.
[19] Han Y,Wang M,Shen J,et al.Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy[J].Minerva Endocrinol,2018,43(1):11-18.
[20] 姚力偀,唐 洁,郑 洁,等.血清相关炎症因子表达水平与老年膝关节骨性关节炎病情严重程度的相关性[J].西部医学,2021,33(1):144-147.
[21] Wang Y,Guo L,Yin X,et al.Pathogenic TNF-α drives peripheral nerve inflammation in an aire-deficient model of autoimmunity[J].Proc Natl Acad Sci U S A,2022,119(4):28-36.
[22] 蒋 洁,任加强,王 铮,等.苦参素通过调控神经生长因子表达抑制背根神经节生长和疼痛递质释放研究[J].陕西中医,2022,43(11):1491-1494,1505.
[23] He Q,Chen B,Chen S,et al.MBP-activated autoimmunity plays a role in arsenic-induced peripheral neuropathy and the potential protective effect of mecobalamin[J].Environ Toxicol,2021,36(6):1243-1253.
[24] 罗选翔,经 历,潘 彬,等.甲钴胺联合鼠神经生长因子促进脊髓型颈椎病术后神经功能的恢复[J].中国组织工程研究,2021,25(5):719-722.
[25] 代 丽,余 航,陈 华,等.针灸结合黄芪桂枝五物汤对保守治疗肘管综合征患者IL-1、NGF和功能恢复的影响[J].长春中医药大学学报,2022,38(9):1011-1014.
[26] 马增斌,邸学士,袁巧妹,等.基于网络药理学探讨黄芪桂枝五物汤治疗颈椎病的作用机制[J].中国中医基础医学杂志,2022,28(6):969-974.

相似文献/References:

[1]时文才,聂晨旭,胡晓龙,等.黄芪桂枝五物汤合血府逐瘀汤联合针灸治疗早期强直性脊柱炎临床研究*[J].陕西中医,2020,(3):315.
[2]周燕飞,孔文良,杨晓媛,等.针刺“五输穴”联用黄芪桂枝五物汤加减治疗神经根型颈椎病疗效研究[J].陕西中医,2022,(10):1463.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.035]
　ZHOU Yanfei,KONG Wenliang,YANG Xiaoyuan,et al.Therapeutic effect and mechanism of acupuncture on “Wushu points” combined with Huangqi Guizhi Wuwu decoction in the treatment of cervical radiculopathy[J].,2022,(12):1463.[doi:DOI:10.3969/j.issn.1000-7369.2022.10.035]

备注/Memo

备注/Memo:
基金项目:河北省中医药管理局中医药类科研计划项目(2021352)
更新日期/Last Update: 2023-12-08