[1]申航旗,何燕南.从“肥胖不孕”探讨肥胖对多囊卵巢综合征的影响[J].陕西中医,2024,(1):84-87.[doi:DOI:10.3969/j.issn.1000-7369.2024.01.019]
　SHEN Hangqi,HE Yannan.Effects of obesity on polycystic ovary syndrome from perspective of “obesity infertility”[J].,2024,(1):84-87.[doi:DOI:10.3969/j.issn.1000-7369.2024.01.019]
点击复制

从“肥胖不孕”探讨肥胖对多囊卵巢综合征的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年1期
页码:
84-87
栏目:
学术探讨
出版日期:
2024-01-05

文章信息/Info

Title:
Effects of obesity on polycystic ovary syndrome from perspective of “obesity infertility”
作者:
申航旗1; 2; 何燕南1; 2
(1.天津中医药大学第一附属医院妇科,天津 300193; 2.国家中医针灸临床医学研究中心,天津 300193)
Author(s):
SHEN Hangqi; HE Yannan
(Department of Gynecology,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
关键词:
多囊卵巢综合征;  不孕;  肥胖;  傅青主女科;  胰岛素抵抗;  高雄激素血症
Keywords:
Polycystic ovary syndrome;  Infertility;  Obesity;  FU Qing Zhu Nv Ke;  Insulin resistance;  Hyperandrogenemia
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2024.01.019
文献标志码:
A
摘要:
基于《傅青主女科》提出的“肥胖不孕”学说,梳理肥胖与多囊卵巢综合征(PCOS)的必然联系,总结肥胖对神经内分泌及卵巢功能的影响,指出肥胖通过内分泌机制引发胰岛素抵抗、高雄激素血症,并通过脂肪因子、炎症因子等加重胰岛素抵抗,使代谢紊乱和卵巢功能障碍进一步加剧,同时促使脂肪堆积,形成恶性循环。故以“肥胖不孕”的理论引出肥胖对于PCOS的重要作用,并以期为进一步探索中西医结合防治方案提供理论参考。
Abstract:
Based on the theory of “obesity infertility” proposed in FU Qing Zhu Nv Ke,this study examines the inevitable connection between obesity and polycystic ovary syndrome(PCOS),summarizes the impact of obesity on neuroendocrine and ovarian function,and points out that obesity triggers insulin resistance,hyperandrogenism,and exacerbates insulin resistance through endocrine mechanisms such as adipokines and inflammatory factors,further exacerbate metabolic disorders and ovarian dysfunction,while promoting fat accumulation and forming a vicious cycle.Therefore,the theory of “obesity infertility” is used to introduce the important role of obesity in PCOS,and to provide theoretical reference for further exploration of integrated Chinese and western medicine prevention and treatment plans.

参考文献/References:

[1] 袁莹莹,赵君利.多囊卵巢综合征流行病学特点[J].中国实用妇科与产科杂志,2019,35(3):261-264.
[2] KAHAL H,TAHRANI A A,KYROU I,et al.The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome:A cross-sectional study[J].Ther Adv Endocrinol Metab,2020,11:2042018820906689.
[3] 苏念军,何梦渊,戴媛媛,等.肥胖型多囊卵巢综合征不孕患者医学体重管理的研究进展[J].现代妇产科进展,2018,27(11):875-877,879.
[4] 王虎生,阮祥燕,程姣姣,等.肥胖型多囊卵巢综合征的氧化应激与脂代谢关系的研究[J].首都医科大学学报,2021,42(4):540-546.
[5] 陈艳丹,莫政,许浪萍,等.补肾助孕汤对肾阳虚型多囊卵巢综合征不孕症患者中医症候评分、血清性激素水平和卵细胞质量的影响[J].陕西中医,2023,44(5):575-578.
[6] SILVESTRIS E,DEPERGOLA G,ROSANIA R,et al.Obesity as disruptor of the female fertility[J].Reprod Biol Endocrinol,2018,16(1):22.
[7] KASUM M,ORESKOVIC S,CEHIC E,et al.The role of female obesity on in vitro fertilization outcomes[J].Gynecol Endocrinol,2018,34(3):184-188.
[8] 王奥,杨刚毅.脂肪因子与胰岛素抵抗关系的研究进展[J].系统医学,2019,4(23):195-198.
[9] 任娟,苟江.性激素结合球蛋白水平与多囊卵巢综合征合并不孕症患者黄体期短效促性腺激素释放激素激动剂长方案助孕结局相关性分析[J].陕西医学杂志,2021,50(4):435-438.
[10] TANBO T,MELLEMBAKKEN J,BJERCKE S,et al.Ovulation induction in polycystic ovary syndrome[J].Acta Obstet Gynecol Scand,2018,97(10):1162-1167.
[11] 马志宾,陈燕,苏永.促排卵汤对多囊卵巢综合征患者血清淀粉样蛋白P、脂肪因子与白介素-18的影响研究[J].陕西中医,2019,40(5):651-654.
[12] CHE Q,LIU M,ZHANG D,et al.Long noncoding RNA HUPCOS promotes follicular fluid androgen excess in PCOS patients via aromatase inhibition[J].J Clin Endocrinol Metab,2020,105(4):60.
[13] 景彦林,杨修昭,白振军,等.高脂饮食诱导肥胖对雌性生育大鼠卵巢功能的影响[J].中国比较医学杂志,2019,29(8):106-110.
[14] 木良善,赵越,乔杰.肥胖与多囊卵巢综合征的关联性及潜在机制[J].中华生殖与避孕杂志,2018,38(4):343-349.
[15] 朱美文,岳德永,曹作增,等.加味芎归二陈汤联合西药治疗痰湿型多囊卵巢综合征疗效及对患者糖脂代谢和血清性激素水平的影响[J].陕西中医,2022,43(4):442-445.
[16] 杨立,程玲,王志,等.PCOS中肥胖、胰岛素抵抗与炎症的关系[J].华中科技大学学报(医学版),2023,52(4):574-578.
[17] JIANG N X,LI X L.The disorders of endometrial receptivity in PCOS and its mechanisms[J].Reprod Sci,2022,29(9):2465-2476.
[18] RUDNICKA E,SUCHTA K,GRYMOWICZ M,et al.Chronic low grade inflammation in pathogenesis of PCOS[J].Int J Mol Sci,2021,22(7):3789.
[19] GONZALEZ F,CONSIDINE R V,ABDELHADI O A,et al.Inflammation triggered by saturated fat ingestion is linked to insulin resistance and hyperandrogenism in polycystic ovary syndrome[J].J Clin Endocrinol Metab,2020,105(6):e2152-e2167.
[20] 孙守桦,王莉.基于肠道菌群从痰证角度论肥胖[J].中国处方药,2023,21(5):184-188.
[21] 华健,廖洪恢,赖小兵,等.白术颗粒对脾虚湿盛型单纯性肥胖人群肠道菌群的调节作用研究[J].内蒙古中医药,2023,42(1):41-44.
[22] 俞静静,苏洁,颜美秋,等.陈皮降脂药效与黄酮类成分的相关性研究[J].中国中药杂志,2019,44(15):3335-3342.
[23] 张卫欢,李秋云,杨春伟,等.大柴胡汤加减联合利拉鲁肽对肥胖2型糖尿病患者胰岛素抵抗、β-细胞功能和低度炎症反应的影响[J].现代中西医结合杂志,2018,27(1):23-26,30.
[24] 吴林玲,张晗,闫颖,等.哈氏补肾化痰方改善肥胖型多囊卵巢综合征大鼠胰岛素抵抗的机制[J].中华中医药杂志,2022,37(3):1406-1410.
[25] 张晗,吴林玲,闫颖,等.哈氏补肾化痰方对痰湿证多囊卵巢综合征大鼠卵巢局部氧化应激的影响[J].中华中医药杂志,2022,37(4):2280-2283.
[26] 毕富玺,吴林玲,张晗,等.哈氏促排方对多囊卵巢综合征患者子宫内膜容受性和妊娠结局的影响[J].辽宁中医杂志,2022,49(4):83-87.
[27] 卢山,孙小玲,王静,等.多囊卵巢综合征不孕患者治疗期间生活方式管理方案的构建及应用研究[J].中华护理杂志,2023,58(2):141-149.
[28] 李灼,刘树辉,薛沙沙,等.从《黄帝内经》养生理论探讨生活方式对多囊卵巢综合征的影响[J].中华中医药杂志,2022,37(10):6050-6053.
[29] 刘志勤,刘黎敏,陈青青.全程健康教育对多囊卵巢综合征患者自我管理能力及妊娠结局的影响[J].中国健康心理学杂志,2022,30(7):1003-1007.
[30] 邬素珍,陈玉,许焕英.八段锦运动处方治疗卵巢储备功能低下的临床研究[J].中医外治杂志,2020,29(2):3-5.

相似文献/References:

[1]欧丽芬,张莹轩,周英.葛根汤合四逆散在多囊卵巢综合征型痤疮中的应用[J].陕西中医,2017,(06):791.
[2]王改梅,李 晶,张 励,等.苍附导痰方联合法地兰对PCOS合并不孕症患者性激素水平 及子宫内膜容受性的影响*[J].陕西中医,2019,(2):201.
　WANG Gaimei,LI Jing,ZHANG Li,et al.Effect of Cangfu Daotan prescription combined with Fadiland on sex hormone level and endometrial receptivity in PCOS patients with infertility[J].,2019,(1):201.
[3]袁社霞.补肾促排方治疗多囊卵巢综合征排卵障碍性不孕临床研究*[J].陕西中医,2019,(1):12.
　YUAN Shexia..Clinical observation on the therapeutic effect of Bushen Cupai recipe on ovulation disorder infertility in polycystic ovary syndrome[J].,2019,(1):12.
[4]高翠霞,宋红湘.补肾调经汤联合温针灸督脉治疗多囊卵巢综合征疗效及对患者内分泌系统和排卵的影响*[J].陕西中医,2019,(1):21.
[5]石小哲,张大伟.温肾健脾汤治疗多囊卵巢综合征及对患者胰岛素抵抗、 激素水平的影响*[J].陕西中医,2019,(5):637.
　SHI Xiaozhe,ZHANG Dawei..Curative effect of Wenshen Jianpi decoction in the treatment of polycystic ovary syndrome and the influence on insulin resistance and hormone levels[J].,2019,(1):637.
[6]马志宾,陈 燕,苏 永.促排卵汤对多囊卵巢综合征患者血清淀粉样蛋白P、脂肪因子 与白介素-18的影响研究*[J].陕西中医,2019,(5):651.
　MA Zhibin,HU Xiaohua,SU Yong ..Effect of Cupailuan decoction combined with life style on serum SAP, Apelin and IL-18 in women with polycystic ovary syndrome[J].,2019,(1):651.
[7]刘彩娜,李佳佳,李林林,等.温针灸督脉联合克罗米芬治疗肾虚血瘀型多囊卵巢综合征不孕临床研究*[J].陕西中医,2019,(6):803.
[8]李海霞,史秀英,王璀瑛,等.益肾化痰方治疗肥胖型多囊卵巢综合征不孕临床研究[J].陕西中医,2019,(7):839.
　LI Haixia,SHI Xiuying,WANG Cuiying,et al.Clinical study of Yishen Huatan decoction in the treatment of obese polycystic ovarian syndrome infertility[J].,2019,(1):839.
[9]冯亚宏,许 昕△.许昕教授治疗多囊卵巢综合征经验探析*[J].陕西中医,2020,(3):374.
[10]庞苗苗,庞 羽,贺丰杰△.荷叶瓜蒌汤联合炔雌醇环丙孕酮片治疗多囊卵巢综合征临床研究[J].陕西中医,2020,(10):1373.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.008]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82104912)
更新日期/Last Update: 2024-01-09