[1]郭桓博,马瑞雪,朱正望,等.中药基于铁死亡机制防治肝癌研究进展[J].陕西中医,2024,(2):282-285.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.030]
 GUO Huanbo,MA Ruixue,ZHU Zhengwang,et al.Research progress in the prevention and treatment of liver cancer based on the mechanism of iron osis in traditional Chinese medicine[J].,2024,(2):282-285.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.030]
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中药基于铁死亡机制防治肝癌研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年2期
页码:
282-285
栏目:
综 述
出版日期:
2024-02-05

文章信息/Info

Title:
Research progress in the prevention and treatment of liver cancer based on the mechanism of iron osis in traditional Chinese medicine
作者:
郭桓博马瑞雪朱正望朱平生
(河南中医药大学,河南 郑州 450046)
Author(s):
GUO HuanboMA RuixueZHU ZhengwangZHU Pingsheng
(Henan University of Chinese Medicine,Zhengzhou 450046,China)
关键词:
肝癌 铁死亡 氧化应激 铁代谢 肝藏血
Keywords:
Liver cancer Ferroptosis Oxidative stress Iron metabolism The liver stores blood
分类号:
R 735.1
DOI:
DOI:10.3969/j.issn.1000-7369.2024.02.030
文献标志码:
A
摘要:
肝癌是各种慢性肝脏疾病的终末阶段,在我国的发病率及病死率均较高。铁死亡是一种调节性细胞死亡(RCD)的现象,其机制与细胞内铁元素的代谢紊乱和过氧化物堆积有关。近年来对铁死亡相关通路的研究发现,铁死亡与肝癌的防治密切相关。中医认为“肝藏血”,而铁死亡发生的过程与血细胞中的铁存在相关性,积极探索中药调控铁死亡的机制,挖掘并提取传统中药的活性成分,对中药的现代化发展颇有裨益。现通过简单阐述铁死亡发生的机制,对中药如何通过各种通路调节干预肝癌细胞的活性和增殖、诱导肝癌细胞铁死亡进行综述,以期为中药防治该疾病开辟新思路。
Abstract:
Liver cancer is the terminal stage of various chronic liver diseases,and the incidence and mortality rates in China are relatively high.Ferroptosis is a phenomenon of regulated cell death(RCD)that is related to intracellular iron metabolism disturbances and peroxide accumulation.Recent studies on ferroptosis-related pathways have found that ferroptosis is closely related to the prevention and treatment of liver cancer.Traditional Chinese medicine believes that “the liver stores blood”,and the process of ferroptosis is correlated with iron in blood cells,and actively explores the mechanism of traditional Chinese medicine to regulate ferroptosis,and excavates and extracts the active ingredients of traditional Chinese medicine,which is quite beneficial to the modern development of traditional Chinese medicine.In this paper,we briefly describe the mechanism of ferroptosis,and review how traditional Chinese medicine regulates and intervenes in the activity and proliferation of hepatocellular carcinoma cells and induces ferroptosis in hepatocellular carcinoma cells through various pathways,in order to open up new ideas for the prevention and treatment of this disease with traditional Chinese medicine.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(82074340); 河南省“双一流”创建学科中医科学研究专项课题(HSRR-DFCTCM-2023-8-31)
更新日期/Last Update: 2024-02-07