[1]赵 欣,丁冰倩,王雪嫄,等.补肾健脾方对早期先兆流产患者阴道微生态及免疫功能的影响[J].陕西中医,2024,(3):340-344.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.011]
　ZHAO Xin,DING Bingqian,WANG Xueyuan,et al.Effects of Bushen Jianpi prescription on vaginal microecology and immune function in early threatened abortion[J].,2024,(3):340-344.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.011]
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补肾健脾方对早期先兆流产患者阴道微生态及免疫功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
340-344
栏目:
临床研究
出版日期:
2024-03-05

文章信息/Info

Title:
Effects of Bushen Jianpi prescription on vaginal microecology and immune function in early threatened abortion
作者:
赵 欣1 ; 丁冰倩1; 王雪嫄1; 傅金英1; 2
(1.河南中医药大学,河南 郑州450046; 2.河南省中医院妇产科,河南 郑州 450002)
Author(s):
ZHAO Xin; DING Bingqian; WANG Xueyuan; FU Jinying
(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China)
关键词:
早期先兆流产;  补肾健脾方;  地屈孕酮;  阴道微生态;  性激素水平;  免疫功能;  妊娠结局
Keywords:
Early threatened abortion;  Bushen Jianpi formula;  Dydrogesterone;  Vaginal microecology;  Sex hormone levels;  Immune function;  Pregnancy outcome
分类号:
R 714.21
DOI:
DOI:10.3969/j.issn.1000-7369.2024.03.011
文献标志码:
A
摘要:
目的:观察地屈孕酮联合补肾健脾方对早期先兆流产患者性激素水平、阴道微生态、免疫功能、妊娠结局等指标的影响。方法:将130例肾虚型早期先兆流产患者随机分成观察组、对照组,每组65例。对照组予地屈孕酮口服,观察组在对照组治疗的基础上加用补肾健脾方颗粒,两组疗程均为2周。观察并比较两组患者治疗前后中医证候积分变化情况、血清性激素水平、阴道微生态变化情况、阴道肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)水平以及妊娠结局。疗程结束后比较两组患者临床疗效,随访统计两组患者妊娠结局。结果:治疗后两组患者中医证候积分、TNF-α水平均较治疗前降低,且观察组低于对照组,差异有统计学意义(均P<0.01)。治疗后两组患者血清人绒毛膜促性腺激素(β-HCG)、雌二醇(E2)、孕酮(P)、IL-4水平均高于治疗前,且观察组高于对照组,差异有统计学意义(均P<0.01)。治疗后观察组正常阴道微生态的患者多于对照组,细菌性阴道炎(BV)、滴虫性阴道炎(TV)、外阴阴道假丝酵母菌病(VVC)清洁度异常者少于对照组,阴道pH值较观察组下降。观察组临床总有效率为93.4%高于对照组的75.0%,差异有统计学意义(P<0.05)。结论:地屈孕酮联合补肾健脾方能明显缓解早期先兆流产患者临床症状,具有良好的保胎效果,其机制与改善性激素水平、阴道微生态以及免疫状态有关。
Abstract:
Objective:To observe influence of dydrogesterone treatment combined with Bushen Jianpi prescription on sex hormone levels,vaginal microecology,immune function,pregnancy outcomes and other indicators in patients with early threatened abortion(ETA).Methods:130 patients with ETA of kidney deficiency type were randomly divided into observation group and control group,with 65 cases in each group.The control group were given dydrogesterone orally,and the observation group given Bushen Jianpi prescriptionon the basis of the treatment in the control group.The treatment course for both groups was 2 weeks.Observe and compare changes in TCM syndrome scores,serum sex hormone levels,changes in vaginal microecology,vaginal TNF-α and IL-4 levels and pregnancy outcomes between the two groups before and after treatment.After the course of treatment,the clinical efficacy were compared,and pregnancy outcomes of the two groups were followed up.Results:After treatment,the TCM syndrome scores and TNF-α levels of the two groups were significantly lower than before treatment,and the observation group significantly lower than the control group,difference statistically significant(all P<0.01).After treatment,the serum β-HCG,E2,P levels,IL-4 levels of the two groups were higher than before treatment,and the observation group significantly higher than those in the control group,difference statistically significant(all P<0.01).After treatment,more patients in the observation group had normal vaginal microecology than those in thecontrol group.BV,TV,and VVC with abnormal cleanliness in the observation group were lower than those in the control group.pH in the observation group was significantly lower than that of the observation group.The total clinical effective rate of the observation group was 93.4% significantly higher than that in the control group 75.0%,difference statistically significant(P<0.05).Conclusion:Dydrogesterone combined with Bushen Jianpi recipe can significantly alleviate clinical symptoms of patients with ETA and has good fetal protection effect.The mechanism was related to improving sex hormone levels,vaginal microecology and immune status.

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备注/Memo

备注/Memo:
基金项目:河南省科技发展计划项目(222102310459); 河南省中医药科学研究专项课题(2022ZY2034); 河南中医药大学科技协同创新专项课题(XTCX2021-04)
更新日期/Last Update: 2024-03-08