[1]李 芳,赵林涛,鱼 涛.柴枳和胃胶囊对功能性消化不良肝郁脾虚证模型大鼠胃排空及胃肠激素的影响[J].陕西中医,2024,(5):600-604.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.005]
　LI Fang,ZHAO Lintao,YU Tao.Effects of Chaizhi Hewei capsule on gastric emptied in model rats of functional dyspepsia with liver depression and spleen deficiency syndrome[J].,2024,(5):600-604.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.005]
点击复制

柴枳和胃胶囊对功能性消化不良肝郁脾虚证模型大鼠胃排空及胃肠激素的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年5期
页码:
600-604
栏目:
基础研究
出版日期:
2024-05-05

文章信息/Info

Title:
Effects of Chaizhi Hewei capsule on gastric emptied in model rats of functional dyspepsia with liver depression and spleen deficiency syndrome
作者:
李 芳1; 赵林涛2; 鱼 涛1
(1.陕西省中医医院,陕西 西安 710003; 2.陕西省中医药研究院,陕西 西安 710003)
Author(s):
LI Fang; ZHAO Lintao; YU Tao
(Shaanxi Province Hospital of Traditional Chinese Medicine,Xi'an 710003,China)
关键词:
功能性消化不良;  柴枳和胃胶囊;  肝郁脾虚证;  胃排空;  胃动素;  机制研究
Keywords:
Functional dyspepsia;  Chaizhi Hewei capsule;  Liver depression and spleen deficiency;  Gastric empty;  Motilin;  Mechanism research
分类号:
R 723.1
DOI:
DOI:10.3969/j.issn.1000-7369.2024.05.005
文献标志码:
A
摘要:
目的:本研究从胃排空的角度探讨柴枳和胃胶囊治疗功能性消化不良(FD)肝郁脾虚证的可能机制。方法:60只SD大鼠随机分为造模组50只和空白对照组10只。造模组大鼠采用限量营养法和夹尾刺激法建立功能性消化不良肝郁脾虚证模型。50只大鼠随机分为模型组、吗丁啉组及柴枳和胃胶囊大、中、小剂量组,每组10只。吗丁啉组给予2.7 mg/kg吗丁啉灌胃,柴枳和胃胶囊大、中、小剂量组分别给予0.630、0.315、0.158 g/kg剂量的柴枳和胃胶囊灌胃。空白组仅给予纯净水灌胃。检测大鼠体重、水量、食量、血清中一氧化氮(NO)、生长抑素(SS)、胃动素(MTL)含量、胃排空以及离体胃肌条活动指标。结果:柴枳和胃胶囊可降低血清中NO和SS含量,升高MTL含量,提高FD模型大鼠胃排空率,提高离体胃肌条运动振幅,提高食量及增加体重。结论:柴枳和胃胶囊对肝郁脾虚型功能性消化不良大鼠模型有明显的改善作用,其机制可能是通过改变血清中神经递质SS、NO、MTL的含量来实现。
Abstract:
Objective:To investigate the potential mechanism of Chaizhi Hewei capsule in the treatment of functional dyspepsia with liver depression and spleen deficiency syndrome from gastric emptied.Methods:Sixty SD rats were randomly divided into modeling group(n=50)and blank group(n=10).The rat model of functional dyspepsia with liver depression and spleen deficiency was established by the combination of limited nutrition method and tail-clamping stimulation method.The effects of this product on body weight,water quantity,food intake,serum contents of NO,SS,MTL,gastric emptied and isolated gastric muscle strip activity of the model rats were investigated.Results:This product can reduce the contents of NO and SS in serum,increase the content of MTL,improve the gastric empties rate of FD model rats,improve the motion amplitude of isolated gastric muscle strips,increase the amount of food and increase body weight.Conclusion:This product has obvious improvement effect on functional dyspepsia rat model with liver depression and spleen deficiency,and the mechanism may be realized by changing the contents of neurotransmitters SS,NO and MTL in serum.

参考文献/References:

[1] BRIAN E L R,CHRISTOPHER C,DAVID J.The treatment of functional dyspepsia:Present and future[J].Expert Review of Gastroenterology & Hepatology,2023,17(1):9-20.
[2] PESCE M,CARGIOLLI M,CASSARANO S,et al.Diet and functional dyspepsia:Clinical correlates and therapeutic perspectives[J].World J Gastroenterol,2020,26(8):456-465.
[3] LACY B E,WEISER K T,KENENDY A T,et al.Functional dyspepsia:The economic impact to patients[J].Aliment Pharm Ther,2013,38(2):170-177.
[4] ARO P,TALLEY N J,AGREUS L,et al.Functional dyspepsia impairs quality of life in the adult population[J].Aliment Pharmacol Ther,2011,33(11):1215-1224.
[5] KOLOSKI N A,TALLEY N J,BOYCE P M.Epidemiology and health care seeking in the functional GI disorders:A population-based study[J].Am J Gastroenterol,2002,97(9):2290-2299.
[6] MAHADEVA S,YADAV H,EVERETT S M,et al.Factors influencing dyspepsia-related consultation:Differences between a rural and an urban population[J].Neurogastroenterol Motil,2011,23(9):846-853.
[7] FORD A C,FORMAN D,BAILEY A G,et al.Who consults with dyspepsia? Results from a longitudinal 10-yr follow-up study[J].Am J Gastroenterol,2007,102(5):957-965.
[8] 王小娟,周恒,郭璇,等.舒胃汤对功能性消化不良大鼠胃肠动力及ENS-ICC-SMC网络超微结构的影响[J].中国实验方剂学杂志,2014,20(24):134-139.
[9] 郭海军,林洁,李国成,等.功能性消化不良的动物模型研究[J].中国中西医结合消化杂志,2001,9(3):141-142.
[10] 刘红,徐寅,王小娟,等.舒胃汤对功能性消化不良大鼠胃排空、血清NO、血浆SP的影响[J].中医药学报,2012,40(4):18-20.
[11] 翟宏丽.功能性消化不良胃肠动力障碍与胃肠激素的关系[J].胃肠病学和肝病学杂志,2003,12(4):318-321.
[12] 沈佳妮,魏强.半夏泻心汤加减治疗功能性消化不良的疗效观察及对胃肠激素的影响[J].中国中医药科技,2022,29(6):981-983.
[13] 邹百仓.槟榔对正常大鼠和功能性消化不良模型大鼠胃运动及胃肠激素的影响[D].南京:南京医科大学,2003.
[14] HIDEKI M,WOUT V,RINA T,et al.Physiological functions and potential clinical applications of motilin[J].Peptides,2023,160:170905.
[15] 金利红,程华军,虞笑娟,等.调中健脾汤联合米曲菌胰酶片对功能性消化不良患者胃肠激素及细胞因子水平的影响[J].中国中西医结合消化杂志,2022,30(11):780-784.
[16] STAR M E,BANER A J,SARR M G.Nitric oxide mediates NANC inhibition by different mechanisms in human and can-inejejunm[J].Gastroenterology,1993,104:389.
[17] KARRAS P J,MICHALOS A,SMITH M E.The role of nitric oxide in esophageal and gastric motor function in the cat[J].Gastroenterology,1993,104(4):530.
[18] 赵芹,林爱华.功能性消化不良与MTL、N、SP、SS的关系[J].中国现代医学杂志,2004,14(11):136-137.
[19] 乔肖伟,基于脑肠轴及相关胃肠激素的变化情况对功能性消化不良胃动力的影响[D].扬州:扬州大学,2021.
[20] YAN L,ZHANG X,LI Y,et al.The role of psychological factors in functional gastrointestinal disorders:A systematic review and meta analysis[J].International Journal of Colorectal Disease,2023,38(1):65.
[21] 陈建德,成家飞.功能性消化不良和胃轻瘫的病理生理学和治疗新进展[J].中华消化杂志,2021,41(1):3-15.
[22] 顾任钧.基于5-HT4R/TAS2R38探讨半夏泻心汤辛开苦降法治疗功能性消化不良的机制[D].南京:南京中医药大学,2022.
[23] 叶影,徐嘉淦,龙惠珍.越鞠丸对功能性消化不良大鼠胃窦黏膜 5-HT 及胃肠激素水平的影响[J].浙江中医药大学学报,2020,44(2):140-145.
[24] 王飞,刘姝,杨成俊.黄芪建中汤合枳实消痞丸加减对功能性消化不良伴睡眠障碍胃肠激素、炎性因子的变化研究[J].中华中医药学刊,2022,40(8):190-193.
[25] 孟淼,吴冬,冯硕.耳甲电针联合柴胡疏肝散对功能性消化不良患者胃肠激素水平及生活质量的影响[J].中国中西医结合消化杂志,2022,30(9):638-642.
[26] 杨倩,蒋潇洒,乔万海,等.陕西省农村成人胃食管反流病、功能性消化不良和肠易激综合征的重叠患病调查[J].中华消化杂志,2021,41(8):522-527.

相似文献/References:

[1]*国家自然科学基金资助项目 (8777).功能性消化不良肝郁脾虚证患者C型钠尿肽与神经营养因子相互作用机制研究进展*[J].陕西中医,2019,(9):1310.
[2]李倩薇,任 明,焦红军.神曲消食口服液联合枸橼酸莫沙必利治疗儿童功能性消化不良疗效研究*[J].陕西中医,2020,(2):198.
　LI Qianwei,REN Ming,JIAO Hongjun..Therapeutic effect of Shenqu Xiaoshi oral liquid combined with mosapride citrate on children with functional dyspepsia[J].,2020,(5):198.
[3]展立芬,邢博文,覃思敏,等.心胃相关理论在功能性消化不良中的运用及机制探析[J].陕西中医,2021,(8):1103.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.029]
　ZHAN Lifen,XING Bowen,Qin Simin,et al.Application and mechanism of psychogastric related theory in functional indigestion[J].,2021,(5):1103.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.029]
[4]林瑞芳,俞赟丰,阳凌峰,等.基于肠道菌群探讨中医药治疗功能性消化不良研究进展[J].陕西中医,2022,(11):1647.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
　LIN Ruifang,YU Yunfeng,YANG Lingfeng,et al.Research progress on treatment of functional dyspepsia with traditional Chinese medicine based on intestinal flora[J].,2022,(5):1647.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.037]
[5]苏坤涵,刘万里.从“善治脾者,能调五脏”论治功能性消化不良[J].陕西中医,2023,(2):216.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.018]
　SU Kunhan,LIU Wanli.Explore the treatment of functional dyspepsia from “Those who are good at curing the spleen can regulate the five internal organs”[J].,2023,(5):216.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.018]
[6]熊 啸,徐天舒.基于脑肠互动探析中医药改善功能性消化不良的作用机制[J].陕西中医,2023,(2):224.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.020]
　XIONG Xiao,XU Tianshu.Exploring the mechanism of traditional Chinese medicine to improve functional dyspepsia based on brain-gut interaction[J].,2023,(5):224.[doi:DOI:10.3969/j.issn.1000-7369.2023.02.020]
[7]姚函伶,乐 薇,范建超,等.电针对功能性消化不良模型大鼠行为学及下丘脑5-HT3R、CRH mRNA表达的影响[J].陕西中医,2023,(6):699.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.004]
　YAO Hanling,LE Wei,FAN Jianchao,et al.Effect of electroacupuncture on behaviors and expression of 5-HT3R and CRH mRNA in hypothalamics of functional dyspepsia rats[J].,2023,(5):699.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.004]
[8]谢家诚,马晓聪,杨靖芸,等.罗伟生从肝胃论治功能性消化不良经验[J].陕西中医,2023,(6):766.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.019]
[9]陈思清,徐 寅,蔺晓源,等.四磨汤对肝脾气滞证功能性消化不良大鼠十二指肠低度炎症及肥大细胞脱颗粒的影响[J].陕西中医,2023,(10):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]
　CHEN Siqing,XU Yin,LIN Xiaoyuan,et al.Effect of Simo decoction on low-grade inflammation of duodenum and degranulation of mast cells in rats with functional dyspepsia[J].,2023,(5):1344.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.003]
[10]耿 琦,李敬伟,凌江红,等.半夏泻心汤对功能性消化不良大鼠抑郁状态及促肾上腺皮质激素释放因子相关通路的影响[J].陕西中医,2024,(2):147.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.001]
　GENG Qi,LI Jingwei,LING Jianghong,et al.Effects of Banxia Xiexin decoction on depressive state and CRF-related pathways in rats with functional dyspepsia[J].,2024,(5):147.[doi:DOI:10.3969/j.issn.1000-7369.2024.02.001]
[11]李 芳,鱼 涛,郭亚男,等.柴枳和胃胶囊治疗功能性消化不良餐后不适综合征肝郁脾虚证疗效研究[J].陕西中医,2022,(9):1222.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.016]
　LI Fang,YU Tao,GUO Yanan,et al.Clinical effect on Chaizhi Hewei capsule in the treatment of functional dyspepsia postprandial distress syndrome of Ganyu Pixu[J].,2022,(5):1222.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.016]

备注/Memo

备注/Memo:
基金项目:陕西省科技厅社会发展攻关计划项目(2013K14-02-02)
更新日期/Last Update: 2024-05-09