[1]丁艳琦,郝皖蓉,冷玉玲,等.草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态临床观察[J].陕西中医,2024,(5):646-649.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.016]
　DING Yanqi,HAO Wanrong,LENG Yuling,et al.Clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors[J].,2024,(5):646-649.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.016]
点击复制

草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态临床观察
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年5期
页码:
646-649
栏目:
临床研究
出版日期:
2024-05-05

文章信息/Info

Title:
Clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors
作者:
丁艳琦; 郝皖蓉; 冷玉玲; 徐 珩; 周先阳; 马 丽; 曾永蕾; 夏克春
(安徽中医药大学第二附属医院肿瘤科,安徽 合肥 230001)
Author(s):
DING Yanqi; HAO Wanrong; LENG Yuling; XU Heng; ZHOU Xianyang; MA Li; ZENG Yonglei; XIA Kechun
(Department of Oncology,Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230001,China)
关键词:
恶性肿瘤;  高凝状态;  凝血指标;  静脉血栓栓塞症;  草灵丹加减;  温经浴袋
Keywords:
Malignant tumors;  Hypercoagulable state;  Coagulation indicators;  Venous thromboembolism;  Modified Caoling pill;  Warming meridian bath bag
分类号:
R 364.15
DOI:
DOI:10.3969/j.issn.1000-7369.2024.05.016
文献标志码:
A
摘要:
目的:探究草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态的临床疗效。方法:选取恶性肿瘤高凝状态患者60例,按照随机对照法分为对照组和试验组,各30例。对照组采用肿瘤常规治疗加注射依诺肝素钠,试验组采用肿瘤常规治疗、注射依诺肝素钠、草灵丹加减、温经浴袋。对比两组治疗前后中医证候积分、凝血指标[血小板计数(PLT)、纤维蛋白原(FIB)、D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、静脉血栓栓塞症(VTE)风险评估及生存质量[卡氏功能状态量表(KPS)],分析两组治疗过程中不良反应发生情况。结果:治疗后两组凝血指标PT、APTT及KPS较治疗前显著升高,且试验组显著高于对照组(P<0.05); 治疗后两组各中医证候积分、凝血指标PLT、FIB、D-D、VTE风险积分降低,且试验组显著低于对照组(P<0.05),试验组不良反应发生率为6.67%,与对照组13.33%比较无统计学差异(P>0.05)。结论:草灵丹加减联合温经浴袋治疗能缓解恶性肿瘤患者高凝状态,改善凝血功能,并降低VTE发生风险,对提高生存质量有积极意义。
Abstract:
Objective:To explore the clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors.Methods:60 patients with malignant tumors in hypercoagulable state were divided into control group and trial group according to the randomized control method,with 30 cases in each group.The control group was treated with enoxaparin sodium on the basis of conventional tumor treatment,and the trial group was treated with modified Caoling pill combined with warming meridian bath bag on the basis of the control group.TCM syndromes scores,coagulation indicators [platelet count(PLT),fibrinogen(FIB),D-dimer(D-D),prothrombin time(PT),activated partial thromboplastin time(APTT)],venous thromboembolism(VTE)risk assessment and quality of life [Karnofsky Performance Scale(KPS)] were compared between the two groups after treatment,and the adverse reactions were analyzed in the two groups during treatment.Results:After treatment,the coagulation indicators of PT and APTT and KPS score in the two groups were significantly enhanced compared to before treatment,and the above indicators in trial group were significantly higher than those in control group(P<0.05).After treatment,TCM syndromes scores,coagulation indicators of PLT,FIB and D-D,VTE risk score in both groups were significantly reduced compared with those before treatment,and the indicators were significantly lower in trial group than those in control group(P<0.05).The incidence of adverse reactions in trial group was 6.67%,which was not significantly different from 13.33% in control group(P>0.05).Conclusion:Modified Caoling pill combined with warming meridian bath bag can alleviate the hypercoagulable state,improve the coagulation function and blood viscosity,relieve the cancer-related fatigue and reduce the risk of VTE in patients with malignant tumors,and it has positive significance for improving the quality of life.

参考文献/References:

[1] 何生奇,冯利,王芳,等.恶性肿瘤高凝状态的防治[J].世界中医药,2010,5(1):53.
[2] 王周勤,王家林.下肢深静脉血栓形成11例护理体会[J].陕西医学杂志,2010,39(2):252.
[3] 李宜瑶.肿瘤患者静脉血栓栓塞抗凝出血与复发风险研究进展[J].中国肿瘤临床,2020,47(24):1287-1292.
[4] 常卫,闫明亮,王建新,等.溶栓治疗恶性肿瘤并发下肢深静脉血栓36例报告[J].陕西医学杂志,2010,39(9):1190-1191.
[5] 张晨,宋国瑞,刘子歌,等.低分子肝素与利伐沙班预防全膝关节置换术后静脉血栓成形的疗效及安全性对比分析[J].陕西医学杂志,2020,49(9):1153-1156.
[6] 冯艺兰,蓝兰,赵晶,等.论活血化瘀法治疗恶性肿瘤[J].四川中医,2017,35(1):30-32.
[7] 张明发,沈雅琴.温里药温经止痛除痹的药理研究[J].中国中医药信息杂志,2000,7(1):29-32.
[8] 马春霞.中药熏洗消褪老年患者静脉穿刺所致皮下瘀血30例临床观察[J].江苏中医药,2013,45(9):50-51.
[9] 田同德,储真真,陈信义.恶性肿瘤高凝状态与血瘀证相关性及中医防治对策研究[J].北京中医药,2009,28(6):425-427.
[10] 李晓晓,马云飞,李光达,等.恶性肿瘤血液高凝状态的发病机制及中西医治疗进展[J].世界中西医结合杂志,2019,14(11):1619-1623.
[11] 郑洋,孙霈,董青,等.恶性肿瘤高凝状态发病机制与诊断标准探讨[J].中国医刊,2014,49(5):16-20.
[12] 中华人民共和国卫生部.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:378-383.
[13] 中国临床肿瘤学会肿瘤与血栓专家委员会.肿瘤相关静脉血栓栓塞症预防与治疗指南(2019版)[J].中国肿瘤临床,2019,46(13):653-660.
[14] 中国中西医结合学会活血化瘀专业委员会.实用血瘀证诊断标准[J].中国中西医结合杂志,2016,36(10):1163.
[15] 柏和.基层医生肿瘤诊治手册[M].北京:北京大学医学出版社,2008:356.
[16] 王瑾,任艳玲.人参配伍五灵脂对A549人肺腺癌细胞增殖抑制及诱导凋亡的实验研究[J].中国中药杂志,2006,31(7):585-588.
[17] 郝微微,温红珠,马贵同,等.人参皂苷Rg1对DSS诱导溃疡性结肠炎小鼠凝血功能的调节作用[J].中国中西医结合消化杂志,2013,21(5):238-242.
[18] 何小溪,徐华丽,于晓风,等.人参Rb组皂苷对急性血瘀模型大鼠血小板聚集及血液流变学的影响[J].中国药理学通报,2007,23(9):1259-1260.
[19] 宗鑫,吴智春,王媛,等.基于中药整合药理学平台分析保元解毒汤干预恶性肿瘤作用机制研究[J].中华肿瘤防治杂志,2018,25(13):931-934,950.
[20] 赵燕.人参皂苷Rg3对鼻咽癌Th1/Th2细胞因子表达情况及临床治疗效果分析[J].陕西中医,2018,39(1):101-103.
[21] 樊瑞芬.黄芪改善肾病综合征患者血液高凝状态的临床观察[J].中国中西医结合肾病杂志,2001,2(11):672-673.
[22] 朱丽,李静.不同剂量黄芪配伍的补阳还五汤对缺血性脑卒中患者血液流变学及疗效的影响[J].陕西中医,2014,35(9):1145-1147.
[23] 丁繁,王小虎.中药黄芪抗肿瘤研究进展[J].肿瘤学杂志,2013,19(1):64-68.
[24] 俞邦友,杨正桃,范长秋.红花注射液对肺胀痰蒙神窍证患者高凝状态及动脉血气的影响[J].中成药,2015,37(3):686-688.
[25] 马云飞,李光达,李琦玮,等.赤芍活性成分抗肿瘤作用机制研究进展[J].中国药房,2020,31(4):500-504.

相似文献/References:

[1]万晓燕.芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少临床研究[J].陕西中医,2019,(1):100.
　WAN Xiaoyan..Clinical study of Qizhu Fuling decoction in the treatment of malignant tumor after chemotherapy of white blood cell reduction[J].,2019,(5):100.
[2]任 伟,王巧云.参丹散结胶囊联合核磁共振引导下的高强度聚焦超声消融 治疗妇科恶性肿瘤骨转移临床研究*[J].陕西中医,2019,(5):648.
　REN Wei,WANG Qiaoyun..Effect of Danshen Sanjie capsule combined with magnetic resonance imaging guided high intensity focused ultrasound ablation in the treatment of gynecologic malignant tumor bone metastasis[J].,2019,(5):648.
[3]杜世拔,齐红朝,赵争敏,等.白虎桂枝汤加减治疗急性痛风性关节炎临床研究*[J].陕西中医,2020,(9):1258.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.023]
[4]夏道宽,蒋同伯,杨道海,等.温针灸对脑梗死恢复期气虚血瘀型患者炎性因子、神经因子及高凝状态的影响[J].陕西中医,2020,(10):1485.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.041]
　XIA Daokuan,JIANG Tongbo,YANG Daohai,et al.Warm acupuncture and moxibustion for inflammatory factor and nerve factor in patients with cerebral infarction recovery Qixu Xueyu type and the effects of hypercoagulability[J].,2020,(5):1485.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.041]
[5]刘包欣子,金志超,邵 杰,等.王瑞平教授运用解毒散结对药治疗恶性肿瘤经验[J].陕西中医,2021,(11):1601.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.025]
　LIU Baoxinzi,JIN Zhichao,SHAO Jie,et al.Professor WANG Ruiping's experience in treating malignant tumors with paired detoxification and Sanjie herbs[J].,2021,(5):1601.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.025]
[6]简小兰,蒋益兰,蒋盛昶.蒋益兰教授治疗恶性肿瘤骨转移经验[J].陕西中医,2022,(5):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
　JIAN Xiaolan,JIANG Yilan,JIANG Shengchang.Experiences from Professor JIANG Yilan in treating bone metastasis of malignant tumour[J].,2022,(5):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
[7]吉 锋,李展绒,任耀龙,等.化痰通瘀除痹方治疗冠心病合并颈动脉粥样硬化斑块痰瘀困阻证疗效研究[J].陕西中医,2022,(9):1212.[doi:DOI:10.3969/j.issn.1000-7369.2022.09.013]
[8]王 华,罗玉环,王 越,等.化痰宽胸开痹方治疗痰浊困阻型不稳定型心绞痛临床研究[J].陕西中医,2022,(11):1556.[doi:DOI:10.3969/j.issn.1000-7369.2022.11.015]
[9]陈 玉,肖海娟,王惠玲,等.基于伏邪理论探讨恶性肿瘤发病机制[J].陕西中医,2022,(12):1760.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.026]
[10]梁奡晟雄,周红光.温滋解毒法治疗恶性肿瘤理论探讨[J].陕西中医,2023,(7):913.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.020]

备注/Memo

备注/Memo:
基金项目:安徽省中医药传承创新科研项目(2022CCZD03)
更新日期/Last Update: 2024-05-09