[1]刘 茜,陈爱林,王 颖,等.徐玲治疗风湿寒性关节痛用药规律分析[J].陕西中医,2024,(5):679-682.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.024]
　LIU Qian,CHEN Ailin,WANG Ying,et al.An analysis on the medication rules adopted by XU Ling in the treatment of wind-dampness-cold arthralgia based on data mining[J].,2024,(5):679-682.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.024]
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徐玲治疗风湿寒性关节痛用药规律分析
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年5期
页码:
679-682
栏目:
长安医学
出版日期:
2024-05-05

文章信息/Info

Title:
An analysis on the medication rules adopted by XU Ling in the treatment of wind-dampness-cold arthralgia based on data mining
作者:
刘 茜; 陈爱林; 王 颖; 白 琳; 樊亚红
(西安市第五医院,陕西 西安 710082)
Author(s):
LIU Qian; CHEN Ailin; WANG Ying; BAI Lin; FAN Yahong
(Xi'an No.5 Hospital,Xi'an 710082,China)
关键词:
风湿寒性关节痛;  长安徐氏风湿流派;  徐玲;  临床经验;  数据挖掘;  祛邪守中
Keywords:
Wind-dampness-cold arthralgia;  Chang'an XU's school for rheumatism;  XU Ling;  Clinical experience;  Data mining;  Dispelling evil and safeguarding right
分类号:
R 593.22
DOI:
DOI:10.3969/j.issn.1000-7369.2024.05.024
文献标志码:
A
摘要:
目的:通过数据挖掘方法,总结、提炼名医徐玲治疗风湿寒性关节痛的用药规律。方法:通过用数据挖掘方法分析徐玲治疗风湿寒性关节痛处方,探索名医徐玲治疗风湿寒性关节痛的用药规律及相关学术经验。结果:最终结果统计出名医徐玲一定时间段所涉及到的证型以风湿痹阻证、脾肾亏虚证、风寒阻络证为多,涉及中药有95味,其中频次超过20次的中药为桂枝、白芍、黄芪、甘草、当归、独活、防风等; 四气五味统计出温性药物居多; 药味统计以辛、甘味最多; 药物归脾、肝两经居多; 药物功效以补虚类药物使用频次最多,其次为祛风湿药、解表药等; 通过关联规则可以看出强连接数的药对有16对; 运用聚类分析结果可以得出治疗风湿寒性关节痛的核心处方3个。结论:徐玲治疗风湿寒性关节痛用药分析后得出,以补脾益肾,柔肝止痛,祛邪除痹为治疗原则,体现“祛邪守中”的治疗理念。
Abstract:
Objective:To summarize and extract the medication rules adopted by XU Ling,a famous doctor,in the treatment of wind-dampness-cold arthralgia based on a data mining method.Methods:The prescriptions provided by XU Ling for the treatment of wind-dampness-cold arthralgia were analyzed with the data mining method,and the medication rules as well as related academic experience of XU Ling,the famous doctor,was explored.Results:The final results showed that in a certain period of time,the syndromes involved in XU Ling's diagnosis were mostly of wind-dampness blockage pattern,spleen-kidney deficiency pattern and wind-cold obstruction pattern.There were 95 kinds of Chinese herbs involved in the prescriptions,in which cassia twig,astragalus membranaceus,radix paeoniae alba,radix glycyrrhizae,angelica pubescens,and saposhnicovia divaricata were adopted for more than 20 times.In terms of four properties and five tastes,most of the herbs were of warm nature.In terms of taste,most of them were hot and sweet.The majority of drugs attributed to the spleen or liver meridian,and as regards efficacy,the most frequently used were deficiency tonifying drugs,followed by wind-dampness dispelling drugs,drugs for relieving exterior syndrome anti-surface drugs,and etc.According to the association rules,there were 16 herb pairs strongly related,and a cluster analysis identified 3 core prescriptions for wind-dampness-cold arthralgia.Conclusion:According to the analysis on the medication of Director XU Ling for the treatment of wind-dampness-cold arthralgia,in Mrs.XU's treatment for the disease,the principles are based on invigorating spleen,tonifying kidney,soothing liver and relieving pain,removing evil and eliminating arthralgia,which have reflected the concept of “dispelling evil and safeguarding right” for relevant treatment.

参考文献/References:

[1] 温伟强,黄胜光,陈辉,等.蜂针和麻黄附子细辛汤加味治疗风湿寒性关节痛42例[J].山东中医杂志,2011,30(6):401-402.
[2] 乐文博,李波.桂枝附子汤加味配合外用药治疗风湿寒性关节炎60例[J].陕西中医,2011,32(8):985-986.
[3] 张志毅.再论风湿寒性关节痛[J].内科急危重症杂志,2008,14(2):59-61.
[4] 卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012,18(9):1-4.
[5] 唐仕欢,杨洪军.中医组方用药规律研究进展述评[J].中国实验方剂学杂志,2013,19(5):278-282.
[6] 唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329-331.
[7] 许源,宿术兰,王团结,等.桂枝的活性成分与药理活性研究进展[J].中药学,2013,36(4):674-678.
[8] 张蔷,高文远,满淑丽.黄芪中有效成分药理活性的研究进展[J].中国中药杂志,2012,37(21):3203-3207.
[9] 周强,栗占国.白芍总苷的药理作用及其在自身免疫性疾病中的应用[J].中药新药与临床杂志,2003,22(11):687-691.
[10] 张伟健,梁艺钟,李勉力,等.“白芍-甘草”药对在成方制剂中的应用规律[J].陕西中医,2020,41(12):1827-1829.
[11] 张朝辉.白芍药对配伍及临床应用[J].时珍国医国药,2001,12(12):1107-1108.
[12] 邹婧,王悦,张学涛,等.防风的本草考证[J].安徽农业科学,2020,48(11):175-177.
[13] 王一方,孙实,赵新杰,等.基于网络药理学和分子对接技术的“桂枝-白芍”药对治疗骨关节炎的潜在作用机制研究[J].中医临床研究,2022,14(25):7-12.
[14] 陈永财,钱江辉,王彬辉,等.“桂枝与白芍”药对入血成分UPLC-Q/TOF-MS分析[J].中国现代应用药学,2017,34(12):1707-1711.
[15] 陈永财,钱江辉,王彬辉,等.桂枝-白芍药对不同比例配伍对芍药苷在大鼠体内药动学的影响[J].中国临床药理学与治疗学,2017,22(11):1237-1243.
[16] 唐菲,於建鹏,张松.白芍配伍桂枝抗炎的药理学作用及机制[J].湖南中医药大学学报,2012,32(2):5-6.
[17] 黄兆胜,施旭光,朱伟,等.黄芪桂枝五物汤及其配伍抗炎镇痛的比较研究[J].中药新药与临床药理,2005,16(2):93-96.
[18] 时文才,聂晨旭,胡晓龙,等.黄芪桂枝五物汤合血府逐瘀汤联合针灸治疗早期强直性脊柱炎临床研究[J].陕西中医,2020,41(3):315-317,337.
[19] 戴琴,徐骁.黄芪桂枝五物汤加味联合玉女煎治疗糖尿病周围神经病变临床研究[J].陕西中医,2018,39(4):482-484.
[20] 田代华.实用中药辞典[M].北京:人民卫生出版社,2002:177.
[21] 刘瑶,焦豪妍.川乌毒理与药理现代研究进展[J].云南中医中药杂志,2010,31(3):66-67.
[22] 周璐丽,曾建国.独活化学成分及药理活性研究进展[J].中国现代中药,2019,21(12):1739-1748.
[23] 杨茜,宁珑,许春萍,等.独活寄生汤对胶原性骨关节炎大鼠干预机制[J].陕西中医,2022,43(12):1673-1676.
[24] 陈荣昌,孙桂波,张强,等.附子及其复方中药的药理作用研究进展[J].中草药,2014,45(6):883-888.
[25] 陈思思,李平,邵翠丽,等.李平教授关于附子反半夏用药经验总结[J].陕西中医,2019,40(9):1278-1280.
[26] 李占玲,杨东,曹永仓.桂枝附子汤治疗关节炎疾病的文献研究[J].中国药物经济学,2023,18(5):119-125.
[27] 赵兴梅,徐光忠,李建利,等.川牛膝和怀牛膝的现代药理研究概况[J].华西药学杂志,2004,19(3):205-207.
[28] 孙福荣,周信,郭杨,等.单味中药对骨质疏松影响的研究概述[J].中国骨质疏松杂志,2012,18(7):667-669.

备注/Memo

备注/Memo:
基金项目:陕西省中医学术流派传承工作室长安徐氏风湿病学术流派传承工作室项目(SXZYLP-2024010); 西安市中医药管理局中医药科研项目(SZL202112)
更新日期/Last Update: 2024-05-09