[1]张 岭,杨 帆,杨晓晓,等.小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎临床研究[J].陕西中医,2024,(5):700-703.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.029]
　ZHANG Ling,YANG Fan,YANG Xiaoxiao,et al.Clinical curative effect of small needle-knife combined with Xibi pill in knee osteoarthritis of cold-damp arthralgia syndrome[J].,2024,(5):700-703.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.029]
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小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎临床研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年5期
页码:
700-703
栏目:
针灸经络
出版日期:
2024-05-05

文章信息/Info

Title:
Clinical curative effect of small needle-knife combined with Xibi pill in knee osteoarthritis of cold-damp arthralgia syndrome
作者:
张 岭; 杨 帆; 杨晓晓; 杨 洋; 张成勇; 刘陆勇
(滨州市中医医院骨伤科,山东 滨州 256600)
Author(s):
ZHANG Ling; YANG Fan; YANG Xiaoxiao; YANG Yang; ZHANG Chengyong; LIU Luyong
(Department of Orthopedics and Traumatology,Binzhou Hospital of Traditional Chinese Medicine,Binzhou 256600,China)
关键词:
湿痹阻型膝关节骨性关节炎;  小针刀;  膝痹丸;  关节液聚基质蛋白;  胶原蛋白2-1;  炎症因子
Keywords:
Knee osteoarthritis of cold-damp arthralgia syndrome;  Small needle-knife;  Xibi pill;  Cartilage oligomeric matrix protein in joint fluid;  Collagen 2-1;  Inflammatory factor
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7369.2024.05.029
文献标志码:
A
摘要:
目的:探讨小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎(KOA)的疗效。方法:以104例KOA患者为研究对象,依据1:1简单随机数字表法将入组的KOA患者分为观察组与对照组各52例。对照组予以塞来昔布胶囊口服,观察组在对照组基础上应用小针刀联合膝痹丸治疗,两组治疗期均为8周。治疗后比较两组临床疗效、中医证候积分、疼痛视觉评分(VAS)、骨关节炎指数(WOMAC)、膝关节(AKS)、血清C反应蛋白(CRP)、血清素-6(IL-6)、关节液聚基质蛋白(COMP)和关节液胶原蛋白2-1(Coll2-1)水平,记录治疗期间不良反应发生情况。结果:观察组KOA患者经中医治疗后总有效率为94.23%,优于对照组78.85%(P<0.05)。治疗后两组KOA患者中医证候积分均降低,且观察组较之对照组更低(P<0.05)。治疗后两组KOA患者VAS、WOMAC评分、血清CRP、IL-6水平、关节液COMP、Coll2-1水平较之治疗前均明显降低,且观察组较之对照组更低(P<0.05); AKS评分均升高,且观察组较之对照组更高(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论:小针刀联合膝痹丸治疗寒湿痹阻型膝关节骨性关节炎疗效较好,可以减轻中医证候,缓解疼痛,降低骨关节炎生物标志物与炎症因子水平。
Abstract:
Objective:To explore the curative effect of small needle-knife combined with Xibi pill in knee osteoarthritis(KOA)of cold-damp arthralgia syndrome.Methods:According to simple random number table method,a total of 104 patients with KOA were divided into observation group(52 cases)and control group(52 cases).The control group was given oral celecoxib capsules,while observation group was treated with small needle-knife combined with Xibi pills on basis of control group for 8 weeks.After treatment,clinical curative effect,scores of TCM syndromes,visual analogue scale(VAS),Western Ontario and McMaster University Osteoarthritis Index(WOMAC)and arthroscopic knee surgery(AKS),levels of serum C-reactive protein(CRP),interleukin-6(IL-6),cartilage oligomeric matrix protein(COMP)and collagen 2-1(Coll2-1)were compared.Adverse symptoms were recorded during the intervention.Results:The total response rate of observation group was better(94.23% vs 78.85%,P<0.05).After treatment,scores of TCM syndromes(joint swelling,joint pain,morning stiffness,poor joint movement)were decreased in both groups,which were lower in observation group than control group(P<0.05).After treatment,scores of VAS and WOMAC,levels of serum CRP and IL-6,COMP and Coll2-1 in joint fluid were all decreased in both groups,which were lower in observation group than control group(P<0.05),while AKS score was increased,which was higher in observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Curative effect of small needle-knife combined with Xibi pill is good in KOA of cold-damp arthralgia syndrome,which can relieve TCM syndrome and pain,reduce levels of biomarkers and inflammatory factors.

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备注/Memo

备注/Memo:
基金项目:山东省中医药科技项目(M-2023298)
更新日期/Last Update: 2024-05-09