[1]李东楠,侯 博,吴 倩,等.基于“肺合大肠”理论探讨流感病毒与肠屏障损伤相关性[J].陕西中医,2024,(7):942-946.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.018]
　LI Dongnan,HOU Bo,WU Qian,et al.Investigate correlation between influenza virus and intestinal barrier damage based on theory of “Feihe Dachang”[J].,2024,(7):942-946.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.018]
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基于“肺合大肠”理论探讨流感病毒与肠屏障损伤相关性
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
942-946
栏目:
学术探讨
出版日期:
2024-07-05

文章信息/Info

Title:
Investigate correlation between influenza virus and intestinal barrier damage based on theory of “Feihe Dachang”
作者:
李东楠1; 侯 博1; 吴 倩1; 王 海2
(1.黑龙江中医药大学,黑龙江 哈尔滨150040; 2.黑龙江中医药大学附属第一医院儿科,黑龙江 哈尔滨150040)
Author(s):
LI Dongnan; HOU Bo; WU Qian; WANG Hai
(Heilongjiang University of Chinese Medicine,Haerbin 150040,China)
关键词:
肺合大肠;  流感病毒;  肠屏障;  肠道菌群;  黏膜免疫;  脏腑辨证
Keywords:
Feihe Dachang;  Influenza virus;  Intestinal barrier;  Intestinal flora;  Mucosal immunization;  Syndrome differentiation of viscera
分类号:
R 25
DOI:
DOI:10.3969/j.issn.1000-7369.2024.07.018
文献标志码:
A
摘要:
现代医学理论中肺与大肠在分化发育、生理病理、功能协作、物质联系上有结构、功能、菌群基础作为支撑依据,这与《黄帝内经》藏象篇中脏腑相关理论不谋而合。在外感热病的疾病传变中,肺与大肠相关联以及反馈调节机制的“肺病从肠论治”“肠病从肺论治”论述成为近年来的研究热点。基于此,从肠屏障的角度系统归纳总结梳理近年来国内外学者探求流感病毒诱导肺系疾病的作用机制,并通过阐述肺经药以及肺肠同治验方作为工具药验证以肺-肠表里理论为指导的药物对流感病毒诱导的肺系疾病的保护机制,揭示流感病毒中肺与肠在疾病传变中的反馈及药物干预机制,阐明肺-肠表里理论的现代内涵,以期为中医药在病毒性疾病中广谱治疗提供现代依据。
Abstract:
In modern medical theory,lung and large intestine have structural,functional and bacterial bases in terms of differentiation and development,physiology and pathology,functional cooperation and material connection,which coincides with viscera related theories in traditional Chinese medicine classic from Yellow Emperor's Inner Canon.In the exogenous febrile disease,discussion of “lung disease treatment from the large intestine”“large intestine disease treatment from the lung”,which were related to Feihe Dachang and the feedback regulation mechanism,has become research hotspot in recent years.Based on this,systematically summarized and sorted out mechanism of action of influenza virus-induced pulmonary diseases by domestic and foreign scholars in recent years from perspective of intestinal barrier,and verified the protective mechanism of drugs guided by the lung-intestine axis theory,on influenza virus-induced pulmonary diseases by elaborating Feijing medicine and prescription of simultaneous treatment of lung and intestine as tool drugs.To reveal the feedback of Feihe Dachang in disease transmission and mechanism of drug intervention in influenza virus,and clarify the modern connotation of lung-intestine axis theory,in order to provide modern basis for advantages of traditional Chinese medicine in treatment of viral diseases.

参考文献/References:

[1] 沈书扬,傅慧婷.肠-肺轴的中医内涵及临床意义[J].上海中医药杂志,2021,55(8):1-3.
[2] 龙须,刘涛,张欢,等.基于“肺与大肠相表里”探讨“肺病治肠”与肠道微生物的关系[J].江西中医药大学学报,2023,35(6):12-15,19.
[3] 宋也好,游慧婷,姚于飞,等.鱼腥草多糖对脂多糖诱导大鼠慢性炎症肺损伤的保护作用[J].现代食品科技,2020,36(6):1-8.
[4] 简宇,范婷,代凌云,等.基于NOD样受体热蛋白结构域3/胱天蛋白酶-1通路探讨鱼腥草注射液缓解脂多糖诱导的小鼠急性肺炎肺损伤的作用机制[J].安徽医药,2023,27(1):73-78,218.
[5] 廖健婷,郝晨静,李博.鱼腥草抗病毒作用研究进展[J].中药药理与临床,2021,37(5):224-228.
[6] 张晓英,温鸿雁,李小峰.CCR6/CCL20轴在类风湿关节炎中遗传和生物学作用的研究进展[J].临床医药实践,2019,28(3):226-230.
[7] MARTINA M G,GIORGIO C,ALLODI M,et al.Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases[J].European Journal of Medicinal Chemistry,2022,24(3):114703.
[8] ZHU H,LU X,LING L,et al.Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection[J].Journal of Ethnopharmacology,2018,21(8):90-99.
[9] WU Z,DENG X,HU Q,et al.Houttuynia cordata thunb:An ethnopharmacological review[J].Frontiers in Pharmacology,2021,12:714694.
[10] 霍金林,温昊天,胡静,等.宣白承气汤治疗痰热壅肺型重症肺炎的Meta分析[J].上海中医药杂志,2020,54(4):40-45.
[11] MU S,ZHANG J,DU S,et al.Gut microbiota modulation and anti-inflammatory properties of Xuanbai Chengqi decoction in septic rats[J].Journal of Ethnopharmacology,2021,26(7):113534.
[12] 包春秀,姜永红.加味宣白承气汤对肺炎支原体肺炎小鼠肠道菌群及免疫的影响[J].上海中医药杂志,2023,57(7):5-12.
[13] WANG Y,LI N,LI Q,et al.Xuanbai Chengqi decoction ameliorates pulmonary inflammation via reshaping gut microbiota and rectifying Th17/Treg imbalance in a murine model of chronic obstructive pulmonary disease[J].Int Journal Chron Obstruct Pulmon Dis,2021,16(1):3317-3335.
[14] 刘进娜,张婵娟,李娜.补中益气汤调控JAK2/STAT3信号通路对气虚发热证大鼠肠道菌群、免疫功能及神经功能的影响[J].陕西中医,2023,44(5):571-574.
[15] 姜东旭,白鸽,李偲.葛根芩连汤治疗感染性腹泻对肠道损伤因子、大便病原学的影响[J].世界中医药,2020,15(17):2617-2619,2624.
[16] 苏钢,杨光勇,韩雪,等.基于靶向代谢组学探讨葛根芩连汤对抗生素相关性腹泻大鼠粪便短链脂肪酸的影响[J].中国实验方剂学杂志,2024,30(7):1-9.
[17] 杨艳玲,向黎莉,陈鹏飞,等.加味葛根芩连汤对重度湿热型溃疡性结肠炎患者免疫功能及肠黏膜屏障功能的影响[J].辽宁中医杂志,2023,50(3):92-95.
[18] 赵明禄,郑佳,郭玉婷.葛根芩连汤及其加减方治疗溃疡性结肠炎的研究进展[J].中国实验方剂学杂志,2023,29(20):1-12.
[19] 龙鑫月,弓艳霞,唐艳萍.葛根芩连汤加减联合美沙拉嗪治疗大肠湿热型溃疡性结肠炎的临床效果及其对患者肠道菌群、免疫功能和炎症水平的调节[J].中华中医药学刊,2024,42(1):1-12.
[20] 肖奕珂,许华冲,邓力,等.葛根芩连汤发酵液对流感病毒FM1感染模型小鼠的治疗作用[J].广州中医药大学学报,2020,37(8):1555-1560.
[21] GENG Z K,LI Y Q,CUI Q H,et al.Exploration of the mechanisms of Gegen decoction against influenza a virus infection[J].Chinese Journal of Natural Medicines,2019,17(9):650-662.
[22] 黄家望,马心悦,凡博砚,等.Toll样受体4在A型流感病毒诱导的小鼠肺部炎症中的作用机制[J].中国病理生理杂志,2023,39(8):1357-1365.
[23] 徐镠粤.复方中药、益生菌对肠道菌群失调流感小鼠肺中免疫细胞TLR7/NF-κB信号通路的影响[D].广州:暨南大学,2022.
[24] SHI Y,XU H,XIAO Y,et al.Gegen Qinlian decoction downregulates the TLR7 signalling pathway to control influenza a virus infection[J].Biomedicine & Pharmacotherapy,2020,12(1):109471.
[25] DENG L,SHI Y,LIU P,et al.Gegen Qinlian decoction alleviate influenza virus infectious pneumonia through intestinal flora[J].Biomedicine & Pharmacotherapy,2021,14(1):111896.
[26] DANG A T,MARSLAND B J.Microbes meta bolites and the guta “lung axis”[J].Mucosal Immunology,2019,12(4):843-850.
[27] 李立华,邱新萍,郭霞珍.基于“四时五藏阴阳”理论整体论思想的研究不同含氧量对大鼠肺、肠组织VIP、CCK及P物质表达影响的实验观察[J].世界中医药,2018,13(5):1095-1099.
[28] 郑旭锐,杨宇,叶建红,等.从肺肠病理模型CCK8、CGRP、SP、VIP表达探讨“肺与大肠相表里”[J].中成药,2012,34(11):2226-2229.
[29] 许月月,陈敏,谢欣,等.从“脾为之卫”浅析腹泻型肠易激综合征肠黏膜机械屏障损伤机制[J].陕西中医,2021,42(8):1096-1099.
[30] 江娟,李静,夏可,等.反复肺炎患儿肠道菌群与免疫功能指标变化及相关性研究[J].陕西医学杂志,2023,52(9):1200-1203.
[31] 崔新梦,高兴华.肠道-器官轴的研究进展[J].药学研究,2022,41(8):531-536.
[32] ICHINOHE T,PANG I K,KUMAMOTO Y,et al.Microbiota regulates immune defense against respiratory tract influenza A virus infection[J].Proceedings of the National Academy of Sciences,2011,108(13):5354-5359.
[33] XU P,YANG Z,DU S,et al.Intestinal microbiota analysis and network pharmacology reveal the mechanism by which Lianhua Qingwen capsule improves the immune function of mice infected with influenza a virus[J].Frontiers in Microbiology,2022,13:1035941.
[34] GUO L,BAO W,YANG S,et al.Rhei radixet rhizoma in Xuanbai Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza a virus[J].Journal of Ethnopharmacology,2024,31(9):117231.
[35] CHEN Y,JIANG Z,LEI Z,et al.Effect of rifaximin on gut-lung axis in mice infected with influenza a virus[J].Comparative Immunology Microbiology and Infectious Diseases,2021,75(3):101611.
[36] 邓璐,陈莉婧,汪铁山.补充益生菌对接种流行性感冒疫苗后抗体滴度影响的Meta分析[J].临床医药实践,2022,31(1):3-9.
[37] 李正民,李江静,庄莹莹,等.益生菌对脂多糖诱发大鼠脑内神经炎症及认知功能障碍保护作用的实验研究[J].陕西医学杂志,2021,50(7):771-775.
[38] WYPYCH T P,WICKRAMASINGHE L C,MARSLAND B J.The influence of the microbiome on respiratorye halth[J].Nature Immunology,2019,20(10):1279-1290.

相似文献/References:

[1]石 雷,张立新,李立华,等.基于“肺与大肠相表里”理论探讨加味桔梗汤从肺论治骨科术后气滞型便秘临床研究[J].陕西中医,2021,(1):81.[doi:DOI:10.3969/j.issn.1000-7369.2020.01.021]

备注/Memo

备注/Memo:
基金项目:国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015036)
更新日期/Last Update: 2024-07-09