[1]杨竣然,徐子文,陈 遒,等.补阳还五汤有效组分抗缺血性脑卒中研究进展[J].陕西中医,2024,(7):995-998.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.030]
　YANG Junran,XU Ziwen,CHEN Qiu,et al.Research progress on anti-ischemic stroke of effective components of Buyang Huanwu decoction[J].,2024,(7):995-998.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.030]
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补阳还五汤有效组分抗缺血性脑卒中研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
995-998
栏目:
综 述
出版日期:
2024-07-05

文章信息/Info

Title:
Research progress on anti-ischemic stroke of effective components of Buyang Huanwu decoction
作者:
杨竣然; 徐子文; 陈 遒; OROUYE Davys(贝宁共和国); 颜丙春
(扬州大学医学院,江苏 扬州 225001)
Author(s):
YANG Junran; XU Ziwen; CHEN Qiu; OROUYE Davys; YAN Bingchun
(School of Medicine,Yangzhou University,Yangzhou 225001,China)
关键词:
缺血性脑卒中;  补阳还五汤;  有效成分;  神经保护;  细胞凋亡;  炎症反应
Keywords:
Ischemic stroke;  Buyang Huanwu decoction;  Active ingredient;  Neuroprotection;  Apoptosis;  Inflammatory reaction
分类号:
R 255.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.07.030
文献标志码:
A
摘要:
缺血性脑卒中(IS)在中医学属于“中风”范畴,是目前全球发病率最高的急危重症之一,脑缺血再灌注损伤可造成脑功能受损,也是IS重要病理生理过程。近来研究发现,补阳还五汤可有效治疗IS,减轻缺血再灌注对脑组织的损伤。补阳还五汤中的有效成分与抗血小板凝集、减轻细胞凋亡、抗氧化应激与兴奋性毒性、调节自噬与减轻炎症反应、促进神经干细胞增殖与分化有关。现对补阳还五汤有效组分在抗IS中发挥的作用进行综述,为深入开展研究和临床开发应用提供参考。
Abstract:
Ischemic stroke(IS)belongs to category of “Zhongfeng” in traditional Chinese medicine,and it is one of the acute and critical diseases with the highest incidence in the world at present.Cerebral ischemia-reperfusion injury is an important pathophysiological process of the disease.The results showed that active components of the prescription were related to anti-platelet aggregation,anti-apoptosis,anti-oxidative stress and excitotoxicity,regulation of autophagy and inflammation,promotion of proliferation and differentiation of neural stem cells.The effect of Buyang Huanwu decoction on anti-IS reviewed,in order to provide reference for further research and clinical application.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(82274392)
更新日期/Last Update: 2024-07-09