[1]朱雅楠,袁 锐,赵玉磊,等.清热凉血类中药调控PI3K/Akt/mTOR信号通路治疗银屑病研究进展[J].陕西中医,2024,(7):999-1001.[doi:DOI:10.3969/j.issn.1000-7369.2024.07.031]
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清热凉血类中药调控PI3K/Akt/mTOR信号通路治疗银屑病研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年7期
页码:
999-1001
栏目:
综 述
出版日期:
2024-07-05

文章信息/Info

作者:
朱雅楠1袁 锐2赵玉磊1张海龙2崔晓倩2杨素清2
(1.黑龙江中医药大学,黑龙江 哈尔滨150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040)
关键词:
银屑病 清热凉血 磷脂酰肌醇3-激酶 蛋白激酶B 哺乳动物雷帕霉素靶蛋白
分类号:
R 758.63
DOI:
DOI:10.3969/j.issn.1000-7369.2024.07.031
文献标志码:
A
摘要:
银屑病是一种慢性、炎症性疾病,其发病机制复杂,多种免疫炎症因子及相关信号通路的异常表达是病情发生发展的重要因素。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路在银屑病的发病机制中具有重要作用,一些细胞因子通过PI3K/Akt/mTOR信号通路调控角质形成细胞分化过程的表达,进而导致银屑病样皮损的产生。因此抑制PI3K/Akt/mTOR通路的相关研究成为近年来银屑病治疗的热点。目前,清热凉血类中药治疗银屑病具有良好的临床疗效,此类中药单体和中药复方对PI3K/Akt/mTOR信号通路有明显的调控作用。本文通过检索相关文献,分析近年来清热凉血类中药通过PI3K/Akt/mTOR信号通路治疗银屑病的相关方案,总结其干预PI3K/Akt/mTOR信号通路的途径和研究进展。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81973846); 黑龙江省中医药科研项目(LHY2022-132)
更新日期/Last Update: 2024-07-09