[1]阳 光,刘 洁,范艺缤,等.调脏舒痢方外用治疗慢性难愈性创面疗效研究[J].陕西中医,2024,(8):1074-1077.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.014]
　YANG Guang,LIU Jie,FAN Yibin,et al.Curative effect of Tiaozang Shuli prescription on chronic refractory wounds[J].,2024,(8):1074-1077.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.014]
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调脏舒痢方外用治疗慢性难愈性创面疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年8期
页码:
1074-1077
栏目:
临床研究
出版日期:
2024-08-05

文章信息/Info

Title:
Curative effect of Tiaozang Shuli prescription on chronic refractory wounds
作者:
阳 光1; 刘 洁2; 范艺缤3; 杨雯钦2
(1.南充市中医医院外二科,四川 南充 637508; 2.南充市顺庆区人民医院针灸一科,四川 南充 637508; 3.南充市中医医院肛肠科,四川 南充 637508)
Author(s):
YANG Guang; LIU Jie; FAN Yibin; YANG Wenqin
(The Second Department of Surgery,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637508,China)
关键词:
慢性难愈性创面;  调脏舒痢方;  创面愈合;  富血小板血浆;  炎性指标;  创面修复因子
Keywords:
Chronic refractory wounds;  Tiaozang Shuli prescription;  Wound healing;  Platelet-rich plasma;  Inflammatory index;  Wound repair factor
分类号:
R 269
DOI:
DOI:10.3969/j.issn.1000-7369.2024.08.014
文献标志码:
A
摘要:
目的:探究调脏舒痢方外用治疗慢性难愈性创面(CRW)的临床疗效。方法:选取106例CRW患者,将上述患者使用动态随机法分为两组。对照组(n=53)使用PRP凝胶治疗,观察组(n=53)使用调脏舒痢方外用进行治疗,观察两组临床疗效、创面愈合情况、疼痛程度(VAS)和治疗前后炎性指标[白细胞计数和C反应蛋白(CRP)水平]、创面修复因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)和表皮生长因子(EGF)]水平。结果:观察组总有效率高于对照组(P<0.05)。观察组治疗后创面愈合率高于对照组,创面完全愈合时间短于对照组,各时间点VAS评分低于对照组(均P<0.05)。观察组白细胞数和CRP水平低于对照组,VEGF、bFGF和EGF水平高于对照组(均P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:调脏舒痢方外用治疗CRW疗效良好,能有效改善患者创面愈合情况,减轻疼痛程度,降低炎性指标水平,提高创面修复因子水平。
Abstract:
Objective:To explore the clinical curative effect of Tiaozang Shuli prescription for external application in chronic refractory wounds(CRW).Methods:A total of 106 patients with CRW were selected and divided into observation group and control group by dynamic randomization method,with 53 cases in each group.The control group was treated with PRP gel,while observation group was treated with Tiaozang Shuli prescription for external application.The curative effect,wound healing and pain degree(VAS),levels of inflammatory indexes [white blood cell count,C-reactive protein(CRP)] and wound repair factors [vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),epidermal growth factor(EGF)] were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the wound healing rate of observation group was higher than that of control group,the time of complete wound healing was shorter than that of control group,and the VAS score at each time point was lower than that of control group(all P<0.05).Leukocyte count and CRP level in observation group were lower than those in control group,VEGF,bFGF and EGF levels were higher than those in control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical curative effect of Tiaozang Shuli prescription is good in CRW patients,which can effectively improve wound healing,relieve pain,reduce levels of inflammatory indexes and increase levels of wound repair factors.

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备注/Memo

备注/Memo:
基金项目:四川省中医药管理局中医药科研专项课题(2023MS006)
更新日期/Last Update: 2024-08-08