[1]章良瑢,张 磊,朱美冬,等.虎杖清脉饮治疗下肢小血管病早期热郁毒聚证临床观察[J].陕西中医,2024,(9):1195-1198.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.009]
　ZHANG Liangrong,ZHANG Lei,ZHU Meidong,et al.The clinical effect of Huzhang Qingmai decoction in the treatment of early heat depression and toxin accumulation syndrome in lower limb small vessel disease[J].,2024,(9):1195-1198.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.009]
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虎杖清脉饮治疗下肢小血管病早期热郁毒聚证临床观察
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1195-1198
栏目:
临床研究
出版日期:
2024-09-05

文章信息/Info

Title:
The clinical effect of Huzhang Qingmai decoction in the treatment of early heat depression and toxin accumulation syndrome in lower limb small vessel disease
作者:
章良瑢; 张 磊; 朱美冬; 钟 妮; 李 琪; 牛小雨; 陈 鑫
(上海中医药大学附属岳阳中西医结合医院血管外科,上海200437)
Author(s):
ZHANG Liangrong; ZHANG Lei; ZHU Meidong; ZHONG Ni; LI Qi; NIU Xiaoyu; CHEN Xin
(Department of Vascular Surgery,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
关键词:
下肢小血管病;  动脉粥样硬化;  虎杖清脉饮;  热郁毒聚;  清热解毒
Keywords:
Lower extremity small arterial disease;  Atherosclerosis;  Huzhang Qingmai decoction;  Heat toxicity syndrome;  Clearing heat and detoxifying
分类号:
R 654.4
DOI:
DOI:10.3969/j.issn.1000-7369.2024.09.009
文献标志码:
A
摘要:
目的:观察虎杖清脉饮治疗下肢小血管病(LESAD)早期热郁毒聚证的临床治疗效果和安全性。方法:选取70例LESAD早期热郁毒聚证患者随机分为试验组和对照组各35例,两组患者均给予西医常规治疗,在此基础上,试验组给予虎杖清脉饮颗粒治疗,对照组给予虎杖清脉饮安慰剂颗粒治疗,3个月后比较两组临床疗效,治疗前后症状体征积分、中医证候积分,治疗前后脂代谢、糖代谢、炎症因子水平变化、安全性及不良反应情况。结果:试验组总有效率94.11%高于对照组63.33%(P<0.05); 治疗后试验组症状、体征积分及中医证候积分较对照组显著降低(P<0.05); 实验室指标中,治疗后试验组脂代谢、糖代谢、炎症因子水平均较对照组改善(P<0.05)。结论:虎杖清脉饮治疗LESAD早期热郁毒聚证患者临床疗效显著,可明显改善患者临床症状,减少动脉粥样硬化的诱发因素。
Abstract:
Objective:To observe the clinical efficacy and safety of Huzhang Qingmai decoction in the treatment of early heat toxicity syndrome of lower extremity small arterial disease(LESAD).Methods:A total of 70 patients were randomly divided into experimental group and control group,35 patients in each group.Both groups of patients were treated with conventional Western medicine.On this basis,the experimental group was treated with Huzhang Qingmai decoction,while the control group was treated with Huzhang Qingmai decoction placebo granules.After 3 months of treatment,the clinical efficacy of the two groups was evaluated.The symptom and sign scores,traditional Chinese medicine syndrome scores,lipid metabolism,glucose metabolism,inflammatory factor levels before and after treatment,and safety were compared between the two groups.Results:The total effective rate of experimental group was 94.11% higher than that of control group(63.33%).In laboratory indexes,lipid metabolism,glucose metabolism,blood rheology and inflammatory factors in experimental group were improved compared with control group after treatment(P<0.05).Conclusion:Huzhang Qingmai decoction has significant clinical effect in treating LESAD patients with early heat-stagnation and toxic-accumulation syndrome,which can significantly improve clinical symptoms and reduce the predisposing factors of atherosclerosis.

参考文献/References:

[1] 孙吉,江洪,余锂镭.外周动脉疾病与冠心病的相关性研究进展 [J].心血管病学进展,2022,43(8):702-706.
[2] 崔向武,刘洁,何婷婷,等.中医治疗下肢动脉硬化闭塞症研究进展[J].广西医学,2019,41(23):3045-3048.
[3] 赵凯,张磊,奚九一.奚九一治疗动脉硬化性闭塞症经验 [J].中医杂志,2007,48(11):975-976.
[4] HUYNH X N,梁硕,孟毅,等.益气活血清热解毒方治疗动脉粥样硬化临床研究[J].陕西中医,2023,44(6):746-750.
[5] 中国医学会外科分会血管外科学组.下肢动脉硬化闭塞症诊治指南[J].中华普通外科学文献:电子版,2016,10(1):1-18.
[6] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:141.
[7] 朱文锋.证素辨证学[M].北京:人民卫生出版社,2008:195.
[8] 杨博华.动脉硬化闭塞症诊断及疗效标准(2016年修订稿)[J].北京中医药,2016,35(10):909-910.
[9] 马力,苗雨晴,闫盛,等.肝素涂层人工血管在腔内治疗失败的严重下肢缺血血运重建中的应用 [J].中华血管外科杂志,2020,5(1):17-22.
[10] 贾睿博,徐琳.2型糖尿病患者下肢血管病变相关危险因素调查研究[J].陕西医学杂志,2019,48(11):1567-1570.
[11] TROISI N,TURINI F,CHISCI E,et al.Impact of pedal arch patency on tissue loss and time to healing in diabetic patients with foot wounds undergoing infrainguinal endovascular revascularization[J].Korean Journal of Radiology,2018,19(1):47-53.
[12] HIGASHIMORI A,IIDA O,YAMAUCHI Y,et al.Outcomes of one straight-line flow with and without pedal arch in patients with critical limb ischemia [J].Official Catheterization and cardiovascular interventions:Journal of the Society for Cardiac Angiography & Interventions,2016,87(1):129-133.
[13] DIEHM N,ROHRER S,BAUMGARTNER I,et al.Distribution pattern of infrageniculate arterial obstructions in patients with diabetes mellitus and renal insufficiency-implications for revascularization[J].VASA Zeitschrift Fur Gefasskrankheiten,2008,37(3):265-273.
[14] FERRARESI R,MAURI G,LOSURDO F,et al.BAD transmission and SAD distribution:A new scenario for critical limb ischemia [J].The Journal of Cardiovascular Surgery,2018,59(5):655-664.
[15] SKELLY C L,CIFU A S.Screening,evaluation,and treatment of peripheral arterial disease [J].Jama,2016,316(14):1486-1487.
[16] 蔡婉,周华,葛文,等.清脂化瘀颗粒调控Keap-1/Nrf2/ARE介导的氧化损伤抗动脉粥样硬化的作用及机制研究[J].陕西中医,2022,43(2):166-169.
[17] 杨仲原,霍晶晶.从脉痹论糖尿病下肢动脉硬化症辨治[J].中医药临床杂志,2024,36(3):479-483.
[18] 康浩浩,魏齐,魏彦宁.赵凯教授治疗动脉粥样硬化经验举隅[J].中国民族民间医药,2015,24(6):143-144.
[19] 冯君,刘建和,冉俊宁,等.从痰、瘀、虚探讨动脉粥样硬化的中西医病机[J].陕西中医,2020,41(2):217-219.
[20] 奚九一.因邪致瘀祛邪为先——论脉管病的诊治思路与方法[J].上海中医药杂志,2001,35(6):4-6.
[21] 王义成,张磊.奚九一论治脉管病的新思维[J].中国中医药现代远程教育,2011,9(14):13-15.
[22] 刘婷,贺梅娟,胡建庆,等.杨晋翔教授应用“清法”治疗脾胃病的经验[J].环球中医药,2016,9(2):196-198.
[23] 赵凯,张磊,奚九一.清法治疗动脉粥样硬化闭塞症初探[J].中医杂志,2006,47(2):144-145.
[24] 叶根亿,姜旭,王振兴.虎杖苷抗动脉粥样硬化机制研究进展[J].医学综述,2022,28(7):1302-1307.
[25] 于静,付淑莲,张芳英.豨莶草药理活性与临床应用研究概况[J].河北医科大学学报,2011,32(12):1486-1488.

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备注/Memo

备注/Memo:
基金项目:国家重点研发计划项目(2019YFC1711604)
更新日期/Last Update: 2024-09-09