[1]邹 彦,李 骧,杨爱红.基于细胞因子TNF-α、IL-6变化研究小续命汤加减治疗痛性糖尿病周围神经病变阳虚寒凝证疗效[J].陕西中医,2024,(9):1211-1214.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.013]
　ZOU Yan,LI Xiang,YANG Aihong.Study on the effect of modified Xiaoxuming decoction in the treatment of painful diabetic peripheral neuropathy with yang deficiency and cold coagulation syndrome based on the changes in TNF-α and IL-6[J].,2024,(9):1211-1214.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.013]
点击复制

基于细胞因子TNF-α、IL-6变化研究小续命汤加减治疗痛性糖尿病周围神经病变阳虚寒凝证疗效
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1211-1214
栏目:
临床研究
出版日期:
2024-09-05

文章信息/Info

Title:
Study on the effect of modified Xiaoxuming decoction in the treatment of painful diabetic peripheral neuropathy with yang deficiency and cold coagulation syndrome based on the changes in TNF-α and IL-6
作者:
邹 彦; 李 骧; 杨爱红
(青岛大学附属青岛市海慈医院 青岛市中医医院内分泌科,山东 青岛 266071)
Author(s):
ZOU Yan; LI Xiang; YANG Aihong
(Department of Endocrinology,Qingdao Hiser Hospital Affiliated to Qingdao University,Qingdao 266071,China)
关键词:
痛性糖尿病周围神经病变;  阳虚寒凝证;  小续命汤;  肿瘤坏死因子-α;  白介素-6;  炎症因子
Keywords:
Painful diabetes peripheral neuropathy;  Yang deficiency and cold coagulation syndrome;  Xiaoxu ming decoction;  Tumor necrosis factor-α;  Interleukin-6;  Inflammatory factor
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.09.013
文献标志码:
A
摘要:
目的:分析基于细胞因子肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)变化研究小续命汤加减治疗痛性糖尿病周围神经病变(PDPN)阳虚寒凝证的疗效。方法:将102例PDPN患者按照随机数字表法进行分组,对照组(n=51)及治疗组(n=51),对照组实施常规治疗,观察组在上述基础联合小续命汤加减治疗,比较两组临床疗效、Toronto临床神经病变评分(TCSS)、疼痛情况、神经传导速度及血清TNF-α、IL-6 水平,统计不良反应发生情况。结果:治疗组临床总有效率(94.12%)较对照组(72.55%)明显高(P<0.05); 治疗8周后,治疗组TCSS评分、疼痛视觉模拟量表(VAS)评分均相较于对照组更低(P<0.05); 治疗8周后,治疗组周围神经传导速度相较于对照组更高(P<0.05); 治疗8周后,治疗组血清TNF-α、IL-6 水平相较于对照组更低(P<0.05); 两组患者未出现任何不良反应。结论:小续命汤加减治疗阳虚寒凝证PDNP,疗效明显,可改善患者临床症状,缓解疼痛,增加周围神经传导速度,且能下调TNF-α、IL-6 水平。
Abstract:
Objective:To analyze the effect of modified Xiaoxuming decoction in the treatment of painful diabetic peripheral neuropathy(PDPN)with yang deficiency and cold coagulation syndrome based on the changes in tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).Methods:102 patients with PDPN and yang deficiency and cold coagulation syndrome were divided into the control group(n=51)and the treatment group(n=51).The control group was given conventional treatment,while the observation group was treated with modified Xiaoxuming decoction on above basis.The two groups were compared in terms of clinical efficacy,Toronto Clinical Scoring System(TCSS)score of neuropathy,pain degree,nerve conduction velocity,and serum TNF-α and IL-6 levels.The incidence rates of adverse reactions were calculated.Results:The total clinical effective rate of the treatment group(94.12%)was significantly higher than that of the control group(72.55%)(P<0.05).After 8 weeks of treatment,comparison between groups found that TCSS score and Visual Analogue Scale(VAS)score of pain in the treatment group were lower(P<0.05).Peripheral nerve conduction velocity in the treatment group was higher(P<0.05).Serum TNF-α and IL-6 levels in the treatment group were lower(P<0.05).No adverse reactions were observed in either group.Conclusion:Modified Xiaoxuming decoction can achieve significant therapeutic effect on PDNP with yang deficiency and cold coagulation syndrome.It can improve the patients' clinical symptoms,relieve pain,increase peripheral nerve conduction velocity,and downregulate TNF-α and IL-6 levels.

参考文献/References:

[1] GE R,CR A,VA E,et al.Peripheral neuropathy in diabetes mellitus:Pathogenetic mechanisms and diagnostic options[J].Int J Mol Sci2023,24(4):3554.
[2] 黎珊珊,区岛良,张梅,等.紫草素对糖尿病周围神经病变大鼠的治疗作用及对腺苷酸活化蛋白激酶/核因子E2相关因子2信号通路的影响[J].陕西医学杂志,2023,52(6):683-687.
[3] 孙建,刘新宇.三七总皂苷胶囊治疗糖尿病周围神经病变临床疗效及机制研究[J].陕西医学杂志,2020,49(11):1496-1498,1506.
[4] 马运涛,祁乐.乌头汤对痛性糖尿病周围神经病变大鼠疼痛行为及KCNQ2/5通道蛋白表达的影响[J].中国老年学杂志,2021,41(5):1047-1051.
[5] 付雪琴,兰瑞,张勇,等.小续命汤对急性脑缺血再灌注大鼠突触可塑性的影响[J].中国中药杂志,2023,48(14):3882-3889.
[6] 魏薇,赵湜,吕晓玉,等.糖尿病周围神经病变与炎性因子的相关性分析[J].中国糖尿病杂志,2020,28(5):326-330.
[7] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):4-67.
[8] 中国中西医结合学会糖尿病专业委员会,林兰.中西医结合糖尿病诊疗标准(草案)[J].中国中西医结合杂志,2005,25(1):94-95.
[9] 国家食品药品监督管理局.中药新药临床研究指导原则:试行[M].北京:中国医药科技出版社,2002:123-125.
[10] 付永奇,赵庚水,周玲,等.降糖祛瘀汤联合α-硫辛酸治疗颅脑创伤合并糖尿病周围神经病变的疗效及对血清Hcy和BDNF水平影响[J].中华中医药学刊,2023,41(9):239-242.
[11] 杨雪蓉,黄俊,金燊懿,等.穴位埋针联合中药熏洗治疗糖尿病周围神经病变临床观察[J].辽宁中医杂志,2022,49(9):173-177.
[12] 刘月梅,张晓凤,刘厚利,等.许建秦治疗糖尿病周围神经病变气阴两虚兼血瘀证经验[J].陕西中医,2023,44(3):356-358.
[13] 梁庆顺,刘昀玮,李安香,等.消渴痛痹方治疗痛性糖尿病周围神经病变的临床研究[J].北京中医药大学学报,2023,46(11):1554-1560.
[14] 戴琴,徐骁.温阳活血方治疗糖尿病周围神经病变临床研究[J].陕西中医,2020,41(1):70-72.
[15] 张征宇,陈礼平,吴静,等.消渴痹足浴方联合西洛他唑片治疗寒凝血瘀型糖尿病周围神经病变临床疗效观察[J].中华中医药杂志,2022,37(3):1837-1840.
[16] 金燊懿,陈清光,姚政,等.参蝎止痛胶囊治疗糖尿病周围神经病变脉络瘀阻证临床观察[J].中国实验方剂学杂志,2021,27(8):81-87.
[17] 熊兴江.古代“中风”内涵及《千金要方》小续命汤治疗脑梗死,脑出血体会[J].中国中药杂志,2020,45(12):2725-2734.
[18] 赵光峰,刘德浪,许玉皎,等.小续命汤在治疗大面积脑梗死后脑水肿的临床作用[J].中华中医药学刊,2023,41(1):179-182.
[19] 张海燕,肖洪波,朱庆军,等.小续命汤联合针刺治疗周围性面神经麻痹急性期风寒袭络证的随机对照研究[J].中药新药与临床药理,2021,32(6):873-879.
[20] 苗佳晶,贺颖,刘艳杰.芪黄除痹汤结合外洗方对糖尿病周围神经病变神经传导速度改善作用的研究[J].中华中医药学刊,2021,39(6):175-178.
[21] 肖凡,周聪,曹淼,等.黄芪桂枝五物汤通过调节内质网应激对MKR小鼠糖尿病周围神经病变的作用[J].中国实验方剂学杂志,2022,28(16):1-8.
[22] 刘雪琼,黄会芳.附子多糖调控miR-135b-5p对脂多糖诱导血管平滑肌细胞增殖和迁移的影响[J].中成药,2021,43(5):1180-1185.
[23] 付雪琴,王漫漫,兰瑞,等.小续命汤对急性脑缺血再灌注损伤星形胶质细胞活化的影响[J].中国中药杂志,2023,48(21):5830-5837.
[24] 刘畅,邱新萍,马万千.加减消痹汤配合针刺对糖尿病周围神经病变炎症因子和血液流变学指标的影响研究[J].中华中医药学刊,2021,39(12):117-120.
[25] 陈耀,张效科,张欢,等.从“辛味治风”角度探析孙思邈用续命汤及其类方治疗中风的理论基础[J].中医杂志,2021,62(19):1736-1739.

备注/Memo

备注/Memo:
基金项目:山东省中医药科技项目(Q-2022005)
更新日期/Last Update: 2024-09-09